In the backstreets of Liverpool, Eileen Watson lives with her mother Nellie, daughter Mel and her three tearaway sons. Life isn’t great, but they have each other, and family can get you through anything. Or can it? Then Britain declares war on Germany and their lives change forever. The children have to be evacuated, but Mel refuses to go, and so Eileen says goodbye to her mother and sons, moves away from the street they love and faces a future without her precious family.

Kate Owen is a woman fleeing from the past. Leaving a rewarding job in London, she’s uprooted her life and given away her daughter to keep them both safe. Damaged from a traumatic event that broke her family apart, she attempts to find peace in Liverpool. There she meets the seemingly eligible Alex Price, who offers her a glimpse of a happy future. But there are those in London who can never forget what she did and believe she holds the key to the unfinished business she left behind in the capital.

What possible connections might exist between an aged man who used to sell shoes, some ladies of the night, a serial killer, Lime Street Station and a mansion in Southport? The answer lies in love, friendship and the determination to endure all the way to the winning post. Eve, owner and madam at Meadowbank Farm, is keen to secure a deal that keeps her in pocket. But is she a match for Babs, a 'Baby Girl' in this house of ill repute?

Now that her family is grown, content in the knowledge that she loves them, Lucy Henshaw decides she is free to leave. She secretly purchases a beautiful house overlooking the Mersey, and there she plans to start afresh. Within hours, she has met some characters: her new neighbour Moira, who is dying, and sees Lucy as the ideal new companion for her husband; Shirley Bishop, cleaner extraordinaire; and Dr David Vincent, who is grieving for the loss of his young son.

In 1955 Scotland Road residents fear for their futures when government plans threaten to demolish their road. Polly’s Parlour café is the centre for action, where strategies are formed to fight back. But when local priest Father Brennan attacks little Billy Blunt, minds are instead turned to vengeance. Frank Charleson, business entrepreneur turned local hero after saving Billy’s life, finds himself increasingly fond of Polly Kennedy. Polly has a hard enough life as it is.

Andrew Sanderson, brilliant surgeon and renowned musician, is still grieving the death of his wife Mary when his younger daughter turns up on the doorstep having left her philandering husband. It’s not long before the house is overrun with daughters, grandchildren, sons-in-law and a boisterous stray dog called Storm. At Andrew's time of life, is this really what he needs? One thing is sure, home is a lot more interesting than it once was, and things have certainly changed from when he was a boy.

When Matthew’s beloved wife Molly died, long before her time, her son Mark grieved as much as anyone. Mark had always been a disappointment to his father – while the family business, a prosperous antiques and junk shop in Manchester, gradually went into decline during Molly’s illness, Mark was more often out stealing than helping out at the store. Tilly Povey, famous for her whiplash tongue and her copious ironing, watched the boy’s decline with a heavy heart from her house across the street.

The Chandlers had been making candles in Bolton for 500 years, and had given their name to the village of Chandlers Green. The dynasty, now in decline and ruled by Richard Chandler, is reduced to an unhappy household and a few tenanted properties. But Richard continues to behave as though he were lord of the manor.

The O'Neils, who have lost brothers and sons into the bowels of London's East End, keep watch over their one remaining young male, Seamus. Meanwhile, Rosh Allen mourns the loss of her husband. Aided and impeded by her mother, she struggles to raise three fatherless children. With the help of a kind-hearted neighbour, her wounds begin to heal. Tess and Don Compton are on the verge of separation. But what really lies behind her desire to live on the posh side of the street? Behind the three families, two men are at work.

In 1820, Salem Street is sparkling and new: eight small terraced houses built by a Lancashire mill owner for his best workers. Annie Gibson's family is one of the first to move in - a step up in the world for them. But when her mother dies, Annie's happy childhood ends and she is left to bring up her brother and sister. Red-haired, intelligent and startlingly pretty, Annie soon finds herself banished from home by a jealous stepmother. She finds work in the local doctor's household, where she learns about the fascinating world outside Salem Street.

The Tobacco Girls cling together as they realise that the clouds of war are turning dark, the world is becoming more dangerous and their lives more unpredictable.  Bridget Milligan’s big, happy family fragments when her siblings are evacuated to North Devon, then a letter from America further fills her with dismay. Maisie Miles safe haven from both Eddie Bridgeman and her father is jeopardised, and she is forced to move on, but where to this time? Phyllis Mason is struck down by tragedy, and her life spirals downwards into despair until a new horizons beckons.

It is 1945, and all over England people are looking forward to being at peace again. Except for one woman. For recently married Zelda, peace means the return of her husband, and this is bad news indeed. Zelda has had to marry Charlie Fluck because she was pregnant by him. And the Fluck clan are backed by the unsavoury Holes, at the centre of whose criminal empire sits Ma Hole like a large malevolent toad. Not only is Zelda frightened of her husband - and she has reason to be, having lost her baby due to a bad "fall" when Charlie pushed her down the stairs.

London 1964. Patsy Kent, now a mother, grandmother, and even great-grandmother, is discovering that it is her family who give her the most pleasure in life, but also the most pain. Her children, Ellen and David, are both going through difficult times with their marriages. The next generation is also giving Patsy cause for concern: Frances, her only granddaughter, may be enjoying the nightlife of the swinging 60s, but it is about to land her in a whole heap of tragedy and trouble.

Friday the 13th of February 1948 is Hannah Gordon's 36th birthday. Her daughter, Allie, turns 16 on the very same day. What's more, it's a full moon. Hannah doesn't need Grandma Ade's warning that bad luck is coming to realise the odds are against them. A devastating accident sets off a chain of events that will rock the family foundations to the core.

The Great War is over, and sisters Iris and Rose are adjusting to life in their modest Liverpool home after their brother Charlie has returned from the front. But when their mother sends Rose to the beautiful Welsh village of Tregarron to recover from an illness she discovers a new world of possibility at her feet. There, she obtains a job as housemaid to the wealthy but tragic Rhys-Pritchard family and falls in love with the young but troubled head of house. Meanwhile at home, Charlie, keen to improve his social standing, becomes engaged to the daughter of a successful coal merchant, while Iris falls for a porter from the local fruit market. Then tragedy strikes, and the whole family must pull together if they are to survive the turmoil ahead. Their support of one another can only bring them closer together, but will they be forced to put their dreams on hold in the process?