In 1955 Scotland Road residents fear for their futures when government plans threaten to demolish their road. Polly’s Parlour café is the centre for action, where strategies are formed to fight back. But when local priest Father Brennan attacks little Billy Blunt, minds are instead turned to vengeance. Frank Charleson, business entrepreneur turned local hero after saving Billy’s life, finds himself increasingly fond of Polly Kennedy. Polly has a hard enough life as it is.

When Matthew’s beloved wife Molly died, long before her time, her son Mark grieved as much as anyone. Mark had always been a disappointment to his father – while the family business, a prosperous antiques and junk shop in Manchester, gradually went into decline during Molly’s illness, Mark was more often out stealing than helping out at the store. Tilly Povey, famous for her whiplash tongue and her copious ironing, watched the boy’s decline with a heavy heart from her house across the street.

Headmaster Theodore Quinn has lived in Liverpool since coming over from America to fight for Britain in the 1940s. Over ten years later, he is harbouring two secrets and scars that are both physical and emotional. Where women are concerned, he and his secrets are a closed shop, until Tia Bellamy walks into his life. Tia cuts through Theo’s reserve, and the first of his secrets is shared with her.

Now that her family is grown, content in the knowledge that she loves them, Lucy Henshaw decides she is free to leave. She secretly purchases a beautiful house overlooking the Mersey, and there she plans to start afresh. Within hours, she has met some characters: her new neighbour Moira, who is dying, and sees Lucy as the ideal new companion for her husband; Shirley Bishop, cleaner extraordinaire; and Dr David Vincent, who is grieving for the loss of his young son.

In 1946, Alice Quigley returns to her childhood home on Penny Lane, having lost her house in Bootle and three sisters to the bombs that fell over Liverpool. Estranged from her husband Dan, she finds comfort in living closer to her remaining sister, Nellie. But even though the bombs have stopped falling, tremors still rock the family when Alice's reviled mother is kicked out of Nellie's home and seeks vengeance.