In 1946, Alice Quigley returns to her childhood home on Penny Lane, having lost her house in Bootle and three sisters to the bombs that fell over Liverpool. Estranged from her husband Dan, she finds comfort in living closer to her remaining sister, Nellie. But even though the bombs have stopped falling, tremors still rock the family when Alice's reviled mother is kicked out of Nellie's home and seeks vengeance.

In 1955 Scotland Road residents fear for their futures when government plans threaten to demolish their road. Polly’s Parlour café is the centre for action, where strategies are formed to fight back. But when local priest Father Brennan attacks little Billy Blunt, minds are instead turned to vengeance. Frank Charleson, business entrepreneur turned local hero after saving Billy’s life, finds himself increasingly fond of Polly Kennedy. Polly has a hard enough life as it is.

What possible connections might exist between an aged man who used to sell shoes, some ladies of the night, a serial killer, Lime Street Station and a mansion in Southport? The answer lies in love, friendship and the determination to endure all the way to the winning post. Eve, owner and madam at Meadowbank Farm, is keen to secure a deal that keeps her in pocket. But is she a match for Babs, a 'Baby Girl' in this house of ill repute?

Headmaster Theodore Quinn has lived in Liverpool since coming over from America to fight for Britain in the 1940s. Over ten years later, he is harbouring two secrets and scars that are both physical and emotional. Where women are concerned, he and his secrets are a closed shop, until Tia Bellamy walks into his life. Tia cuts through Theo’s reserve, and the first of his secrets is shared with her.

In the backstreets of Liverpool, Eileen Watson lives with her mother Nellie, daughter Mel and her three tearaway sons. Life isn’t great, but they have each other, and family can get you through anything. Or can it? Then Britain declares war on Germany and their lives change forever. The children have to be evacuated, but Mel refuses to go, and so Eileen says goodbye to her mother and sons, moves away from the street they love and faces a future without her precious family.

Kate Owen is a woman fleeing from the past. Leaving a rewarding job in London, she’s uprooted her life and given away her daughter to keep them both safe. Damaged from a traumatic event that broke her family apart, she attempts to find peace in Liverpool. There she meets the seemingly eligible Alex Price, who offers her a glimpse of a happy future. But there are those in London who can never forget what she did and believe she holds the key to the unfinished business she left behind in the capital.

Liverpool, 1917. When Irish seaman Michael Gallagher docks in Liverpool after years of fighting with the British Navy, he never expects to fall in love. But the moment he glimpses Stella Bennett, all thoughts of returning to his homeland vanish. Determined to be together, the young couple defy Stella’s parents’ wishes. But their plans to marry are soon derailed by the arrival of baby Ginny. Her crop of fiery red hair plants a seed of doubt in her father’s mind, and it’s not long before their world begins to fall apart.

The O'Neils, who have lost brothers and sons into the bowels of London's East End, keep watch over their one remaining young male, Seamus. Meanwhile, Rosh Allen mourns the loss of her husband. Aided and impeded by her mother, she struggles to raise three fatherless children. With the help of a kind-hearted neighbour, her wounds begin to heal. Tess and Don Compton are on the verge of separation. But what really lies behind her desire to live on the posh side of the street? Behind the three families, two men are at work.

Emmy Dickens lives with her widowed mother in a neat house in neglected Nightingale Court, but Mrs Dickens has always impressed upon her daughter that her main aim in life must be to escape from the court. Emmy sees that marriage is her best way out, and when Peter Wesley, First Officer aboard a cruise ship, asks her to marry him, she is over the moon. Life goes well for the newlyweds; they set up home and start a family. But when Peter is killed and Emmy is left almost penniless, her problems begin.... 

Dympna Byrne lives a simple life with her family on the Connemara coast. She adores her father Micheál, and does her best to help her family by working hard and expecting little. But beneath the surface there are hidden secrets. Dympna’s mother idolises her clever eldest son, yet her attitude to Dympna is puzzling. So when her family find themselves in desperate need of money, it is Dympna who crosses the water to Liverpool to seek a better life. 

Andrew Sanderson, brilliant surgeon and renowned musician, is still grieving the death of his wife Mary when his younger daughter turns up on the doorstep having left her philandering husband. It’s not long before the house is overrun with daughters, grandchildren, sons-in-law and a boisterous stray dog called Storm. At Andrew's time of life, is this really what he needs? One thing is sure, home is a lot more interesting than it once was, and things have certainly changed from when he was a boy.

August 1940: As the Luftwaffe swarm over Liverpool, Shane Quinn decides to move his family back to the safety of Ireland. But his only child, the beautiful Dana, would rather stay and serve her country than flee to a foreign land. Determined to make it on her own, she joins the WAAF with newfound pals Patty and Lucy. There’s plenty of excitement to be had on a RAF station, even a chance or two at love.

It is a cold December night and Sylvie Dugdale is weeping as she walks by the Mersey. She fails to notice an approaching figure, and jumping to one side to avoid collision, she finds herself struggling in the ice-cold river. Constable Brendan O'Hara, just coming off duty, sees the girl's plight and dives in to rescue her. He is dazzled by her beauty but discovers that Sylvie's husband is in prison, and the closeness that Brendan soon longs for is impossible. But he is able to help her escape from Liverpool....

One wild night in the 1930s, midwife Patty Peel is called to attend a birth on the opposite side of Liverpool. She pedals off into the storm and delivers a baby girl in a filthy slum dwelling, just as the mother dies. The drunk and violent father tells Patty to get rid of it so she takes the child away, meaning to deliver it to the nearest orphanage. However, Patty spent her entire childhood in an institution, except for the frequent occasions when she ran away, and cannot bear to hand the baby over. 

When Dot McCann, playing with her pals, decides to hide in Butcher Rathbone's almost empty dustbin, she overhears a conversation which could send one man to prison and the other to the gallows - and suddenly finds herself in possession of stolen goods. Dot lives with her aunt and uncle, abandoned after her parents died. She feels very alone until she meets up with Corky, who has run away from a London orphanage. They join forces with Emma, whose jeweller's shop has been burgled, and Nick, a young reporter who is investigating the crime.