Kate Owen is a woman fleeing from the past. Leaving a rewarding job in London, she’s uprooted her life and given away her daughter to keep them both safe. Damaged from a traumatic event that broke her family apart, she attempts to find peace in Liverpool. There she meets the seemingly eligible Alex Price, who offers her a glimpse of a happy future. But there are those in London who can never forget what she did and believe she holds the key to the unfinished business she left behind in the capital.

Liverpool, 1940. When war comes to Britain, Jessica Wilson and her friend Ruby seize the opportunity to leave behind the orphanage they grew up in and start new lives in the NAAFI. With only forged papers as identification, the girls expect to be turned away but are delighted with an offer of work. For the first time in their lives they experience real independence, and it isn't long before they're spending their evenings enjoying the delights of Liverpool.

Headmaster Theodore Quinn has lived in Liverpool since coming over from America to fight for Britain in the 1940s. Over ten years later, he is harbouring two secrets and scars that are both physical and emotional. Where women are concerned, he and his secrets are a closed shop, until Tia Bellamy walks into his life. Tia cuts through Theo’s reserve, and the first of his secrets is shared with her.

In 1955 Scotland Road residents fear for their futures when government plans threaten to demolish their road. Polly’s Parlour café is the centre for action, where strategies are formed to fight back. But when local priest Father Brennan attacks little Billy Blunt, minds are instead turned to vengeance. Frank Charleson, business entrepreneur turned local hero after saving Billy’s life, finds himself increasingly fond of Polly Kennedy. Polly has a hard enough life as it is.

Now that her family is grown, content in the knowledge that she loves them, Lucy Henshaw decides she is free to leave. She secretly purchases a beautiful house overlooking the Mersey, and there she plans to start afresh. Within hours, she has met some characters: her new neighbour Moira, who is dying, and sees Lucy as the ideal new companion for her husband; Shirley Bishop, cleaner extraordinaire; and Dr David Vincent, who is grieving for the loss of his young son.

In 1946, Alice Quigley returns to her childhood home on Penny Lane, having lost her house in Bootle and three sisters to the bombs that fell over Liverpool. Estranged from her husband Dan, she finds comfort in living closer to her remaining sister, Nellie. But even though the bombs have stopped falling, tremors still rock the family when Alice's reviled mother is kicked out of Nellie's home and seeks vengeance.

When Matthew’s beloved wife Molly died, long before her time, her son Mark grieved as much as anyone. Mark had always been a disappointment to his father – while the family business, a prosperous antiques and junk shop in Manchester, gradually went into decline during Molly’s illness, Mark was more often out stealing than helping out at the store. Tilly Povey, famous for her whiplash tongue and her copious ironing, watched the boy’s decline with a heavy heart from her house across the street.

What possible connections might exist between an aged man who used to sell shoes, some ladies of the night, a serial killer, Lime Street Station and a mansion in Southport? The answer lies in love, friendship and the determination to endure all the way to the winning post. Eve, owner and madam at Meadowbank Farm, is keen to secure a deal that keeps her in pocket. But is she a match for Babs, a 'Baby Girl' in this house of ill repute?

 1936. Polly's guardian angel has to work overtime when her large family is forced to move from the countryside they love into central Liverpool. Money is desperately short, and with her mother working and her father sick, Polly is easily led astray by the handsome Sunny Andersen. But soon war looms, and Sunny joins the navy to train as a signaller. After the horrors of the May Blitz, Polly, too, decides she wants to help her country and goes into the WRNs. She hears that an old pal, Tad Donoghue from the Dublin slums, is now in the Royal Air Force.

Holding the letter in trembling hands, Daisy’s future crumbled before her – the words engraved on her heart forever. The village of Little Creek, the long winter of 1867. The first flakes of snow are falling when Daisy Marshall, secretly engaged to her master's son, finds herself jilted at the altar. Heartbroken, Daisy flees to the small village of Little Creek, nestled on the coast of Essex. There she is warmly welcomed – but the village is poverty-stricken, suffering under a cruel lord of the manor. And when cholera hits, the villagers are truly in dire straits.

In the backstreets of Liverpool, Eileen Watson lives with her mother Nellie, daughter Mel and her three tearaway sons. Life isn’t great, but they have each other, and family can get you through anything. Or can it? Then Britain declares war on Germany and their lives change forever. The children have to be evacuated, but Mel refuses to go, and so Eileen says goodbye to her mother and sons, moves away from the street they love and faces a future without her precious family.

It wasn't a privileged childhood, but it was a happy one. Sybil and Lizzie Cream, brought up in a fisherman's cottage on the edge of the cold North Sea, were content to leave privilege where it belonged: with their friends the Wintertons. Christina Winterton was the same age as Sybil, and the two girls were inseparable, but it was Lizzie whom Ralph Winterton, three years older, found irresistible. Then war came to East Anglia, and so did Manchester-born Fenn Kitzmann, now of the American Army Air Force.

The Chandlers had been making candles in Bolton for 500 years, and had given their name to the village of Chandlers Green. The dynasty, now in decline and ruled by Richard Chandler, is reduced to an unhappy household and a few tenanted properties. But Richard continues to behave as though he were lord of the manor.

Thwarted in her desire to become a doctor like her brother, Robert, Pips Maitland rebels against her mother's wishes that she settle down and raise children. However, when Robert brings home a friend from medical school, Giles Kendall, it seems perhaps Pips might fall in love with an acceptable suitor after all. But the year is 1914, and the future is uncertain. Hearing that her father's friend, Dr John Hazelwood, is forming a flying ambulance corps to take to the front lines, Pips is determined to become one of its nurses and asks Alice Dawson, her maid, to go with her.

Claudia Muldoon and her sister, Jenny, live with their parents and their gran in her house in Blodwen Street. Both parents have good jobs and the family assume they are settled for life, but then Grandpa Muldoon has a seizure and begs his son to return to Ireland. In Ireland the Muldoons flourish and the girls love the freedom of their new life, though as they grow up, disadvantages become clear. Claudia has to find work, so both sisters return to Liverpool and to their old pal Danny, who welcomes them back with delight.