What if the biggest barrier to life-changing medicine wasn’t science, but the cost of making it?

Harriet speaks with Ali Afshar, the co-founder and CEO of Mytos, a biotech company automating the manufacturing of human tissue to make regenerative medicine affordable and accessible at scale.

Ali believes that within 50 years, every tissue in the body will be replaceable, and that the way there is through engineering, rather than traditional drug discovery.

They get into:

• Why tissue replacement works where drugs fail, and what a 90% fail rate says about the pharmaceutical industry

• The conditions Mytos is targeting first, from Parkinson’s and diabetes to macular degeneration

• Why the UK was the right place to launch, and the role sovereign nations play in funding biotech infrastructure

• Tech as a deflationary force, and Ali’s first principles belief that better healthcare should cost less

• And why keeping hardware, software and biology in one vertically integrated team is non-negotiable.

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Check out Mytos:

https://www.mytos.bio/

https://www.linkedin.com/company/mytosbio/

https://www.linkedin.com/in/ali-afshar-0246002b/

More on Basis:

https://www.buildbasis.com/

https://www.youtube.com/@BasisCapital

https://www.linkedin.com/company/basiscapitalltd/
https://www.linkedin.com/in/harrietsgreen

What happens when the systems we rely on – states, money, infrastructure – start to fall out of sync with the world around them?

Harriet speaks with Stefano Bernardi and Francesco Moiraghi of Unruly Capital, a venture capital firm focused on backing ideas that feel early, unconventional, and often uncomfortable.

Their work centres on a simple thesis: many of the institutions built over the past 70 years are no longer sufficient for what comes next, and new builders and systems are emerging to fill that gap.

They get into:

• Portable sovereignty and the ability to move wealth across borders

• The migration of power from states to technology systems

• The urgency of the AI compute and energy race and what it means for Europe

• A new generation of founders building from conviction

• Bitcoin and programmable money

Subscribe for more interviews with founders, builders, and operators shaping the future of technology, capital, and global systems.

Check out Unruly Capital:

https://unrulycap.com/

https://www.linkedin.com/company/unruly-capital/

https://www.linkedin.com/in/stefanobernardi/

https://www.linkedin.com/in/francesco-moiraghi/

More on Basis:

https://www.buildbasis.com/

https://www.youtube.com/@BasisCapital

https://www.linkedin.com/company/basiscapitalltd/

https://www.linkedin.com/in/harrietsgreen

Harriet sits down with Harvey Hodd, who is working on a 20-year plan to build and scale synthetic fuels – changing how humans generate energy forever.

Rivan is developing a new way to produce synthetic natural gas using sunlight, water, and captured CO2 – with the aim of decarbonising industries that cannot easily be electrified.

Harvey explains how Rivan’s fully vertically integrated model, in-house manufacturing, and low-cost solar strategy could transform the economics of synthetic fuels, direct air capture, and industrial decarbonisation.

They discuss:

• Why cheap solar changes everything for industrial energy

• The benefits of vertical integration in climate tech and hard tech

• Building advanced manufacturing in London and scaling UK industry

• Hiring, apprenticeships, curiosity, and how Rivan evaluates talent

• Capitalism, innovation, energy abundance, and the future of climate solutions

• Rivan’s £25M Series A and plans to build the largest synthetic natural gas plant in Europe

#Rivan #HarveyHodd #ClimateTech #CleanEnergy #UKStartups #FounderInterview

Check out Rivan:

https://rivan.com/

https://www.linkedin.com/company/rivanindustries/

https://www.linkedin.com/in/harveyhodd/

More on Basis:

https://www.buildbasis.com/

https://www.youtube.com/@BasisCapital

https://www.linkedin.com/company/basiscapitalltd/

https://www.linkedin.com/in/harrietsgreen

Subscribe for more conversations on rebuilding institutions, incentives and public services.