Ms. Ladybug and Mr. Honeybee: A Love Story at the End of Time tells the story of a ladybug and a honeybee who find each other after losing their entire families to the poisonous fogs the humans are spraying. The unlikely duo pursues a safe haven from the poisonous fog and are aided by lightning bugs, a mysterious dragonfly, and even cockroaches along the adventure of a lifetime. They encounter doubting ticks, denying termites, and a slug desperately resigned to his fate along their way, but they never give up in their seemingly hopeless quest.