Dr. Will Haas on Cellular Health: Toxins, Testing, Foundational Supplements, and Peptides for Healthspan Jason interviews Dr. Will Haas about why he chose integrative/functional medicine after realizing medical school focused on “sick care” rather than health optimization, a passion rooted in his youth and athletic background and influenced by mentor Andrew Weil’s view that it’s simply “good medicine.” Haas explains his clinical approach starts with lifestyle foundations (sleep, nutrition, stress, social connection) plus targeted diagnostics, listening for cellular dysfunction patterns like mitochondrial energy deficits that can present as brain fog or fatigue. He emphasizes toxins (including mold/mycotoxins), gut-driven inflammation/dysbiosis, and immune dysregulation as key disruptors, advocating “test, don’t guess” before interventions. They discuss practical basics like hydration, personalized nutrition, common supplementation deficiencies he sees (magnesium, vitamin D, B12/folate, vitamin C, omega-3s), and a cautious, mechanism-based view of peptides, highlighting GLP-1s’ early impact and epitalon’s potential role in optimization and circadian rhythm support. Haas shares his own routine and directs listeners to Vyve Wellness for a discovery call. 00:00 Chasing Performance Inputs 00:21 Why Integrative Medicine 01:28 Meet Dr Will Haas 02:40 Olympics Spark Origin Story 05:14 Healthcare Versus Sick Care 07:18 First Patient Assessment Basics 10:27 Cellular Patterns Not Labels 13:44 Brain Fog Wake Up Call 15:33 Toxins Gut And Mold 21:00 Test Before You Detox 23:16 Food Hydration Personalization 27:38 Dark Chocolate Heavy Metals 28:22 Fiber Goop Breakdown 31:24 Gut Health Reality Check 33:00 Avoiding Optimization Burnout 33:46 Supplements Need Data 36:07 Common Deficiencies Explained 39:16 Antioxidants Need Balance 40:35 Peptides Primer and Hype 42:08 Evidence Based Peptide Lens 44:50 GLP1s Sparked Interest 48:47 Peptides by Pathway Not Stacks 50:22 Epitalon and Circadian Reset 51:30 Older Patients and Root Causes 54:10 Doctor Daily Routine 57:05 Training Mindset and Stress 58:27 Wrap Up and How to Work Together 01:00:46 Sponsor Message and Disclaimer

Dylan Livingston on Longevity Policy, Right to Try, and Scaling the Longevity Dividend Jason Wright interviews Dylan Livingston, founder of the Alliance for Longevity Initiatives (A4LI), about advancing longevity through policy rather than products. Livingston traces his interest from discovering Aubrey de Grey as a teen to COVID-era experiences with his grandfather, which renewed his focus and led him to launch A4LI in 2022 as a coalition of longevity biotech companies. He describes passing a California resolution prioritizing longevity and healthy aging, framing the goal as achieving a “longevity dividend” worth trillions through reduced healthcare costs and increased productivity, and argues therapeutics can democratize longevity more than intensive lifestyle protocols. They discuss Right to Try, its limits under terminal-only access and liability concerns, and A4LI’s work expanding access in Montana and New Hampshire for Phase 1-safe therapies. Livingston highlights AI-driven acceleration in biotech, cellular reprogramming with Yamanaka factors, and previews A4LI’s Georgetown DC summit featuring major companies, researchers, policymakers, and a Capitol Hill briefing on US-China biotech competition. 00:00 Cold Open Banter 01:05 Why Longevity Policy 02:17 Dylan Origin Story 05:39 Launching The Alliance 08:24 Sponsor Message 09:18 California Policy Playbook 10:49 Longevity Dividend Explained 12:39 Therapeutics As Equalizer 13:44 Moral Case For Healthspan 17:48 Right To Try Primer 21:17 Fixing Right To Try 22:23 Biotech Valley Of Death 25:22 AI And Medical Gatekeeping 26:01 AI Health Coach Teaser 26:35 Plan Aware Health Coaching 27:31 Longevity Goals And Motivation 29:38 AI Accelerating Biotech 32:10 Cell Reprogramming Breakthroughs 34:32 Aging As Root Cause Policy 37:10 Wellness Mindset And Agency 40:15 Prevention Limits And Lifelong Care 44:33 DC Summit Agenda Preview 46:24 Hill Briefing And Biotech Race 49:20 Wrap Up And Medical Disclaimer

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30 Grams of Protein at Breakfast: The Simple Habit for Metabolism, Muscle, and Longevity In this Healthy CEO podcast episode, Jason argues that “winning the morning” includes strategically timing nutrition, especially getting at least 30 grams of protein at breakfast, to improve metabolism, body composition, energy, and aging. He challenges the assumption that skipping breakfast or only drinking coffee until noon is always healthier, noting research suggesting how you break a fast affects fat loss, muscle preservation, metabolic health, cognitive performance, and longevity. He explains protein’s benefits—higher thermic effect, better blood sugar stability, and greater satiety—and links muscle to healthy aging, citing age-related muscle loss and the role of mTOR and leucine (about 2.5–3 grams per meal). He gives breakfast protein examples and suggests essential amino acids as a practical option for intermittent fasters to support muscle without a full meal, recommending a one-week experiment. 00:00 Morning Protein Setup 01:02 30g Breakfast Challenge 01:44 Fasting and Metabolism 02:54 Why 30g Works 03:56 Muscle and mTOR 05:05 What 30g Looks Like 05:24 EAAs for Intermittent Fasters 06:57 Longevity and Weekly Experiment 08:10 Wrap Up and Disclaimer

Supplements Aren’t the Answer: Exercise, Blood Work, and the NAD Hype Jason Wright, co-founder and CEO of Authentic Health Partners, explains why he gets frustrated when people ask what supplements to take before addressing basics like exercise, sleep, hydration, diet, stress, and relationships. Using questions about NAD (often via NR/NMN precursors or injections) as the catalyst, he says there’s no panacea and nothing will outperform movement, sunshine, and avoiding over-nourishment; he notes calorie restriction is strongly correlated with longevity in studies but not proven causal. He describes Huberman’s NAD use as anecdotal and cautions against copying a “one person study” without considering the full lifestyle context and overall cellular health. Wright recommends getting blood work, consulting a physician, doing research (including randomized controlled trials), and keeping supplementation simple; personally he takes his company’s foundational stack plus creatine and glutathione, and warns GLP-1 users about under-nourishing and losing muscle. 00:00 Why Supplements Trigger Me 01:52 Fix The Basics First 04:09 Longevity Talk Calorie Restriction 05:55 NAD Explained And The Hype 08:49 Huberman N Of One Reality 12:32 How I Answer NAD Questions 16:02 What I Actually Take Daily 17:28 Cell Health Car Engine Analogy 22:21 No Panacea Holistic Health 23:47 GLP 1 Caution And Muscle Loss 25:47 Do Your Homework Closing 27:42 Medical Disclaimer

Creatine Beyond Muscle: Cognitive Benefits, Supplement Basics, and Pragmatic Sports Nutrition with Dr. Jose Antonio Jason Wright interviews Dr. Jose Antonio about creatine’s mainstream status, dosing (3–5 g/day vs. 10–20 g/day), and emerging cognition data, noting higher doses may be needed to raise brain creatine and benefits appear mainly under stress such as sleep deprivation, with vegans/vegetarians responding more. Antonio argues for a pragmatic approach that values RCTs but also real-world evidence, and debunks myths about “better” creatine forms (monohydrate is best studied), puffiness, and liver/kidney harm. He recommends focusing on exercise first, then basics like post-workout protein, creatine, a multivitamin, and omega-3s, with performance aids (sodium bicarbonate, beta-alanine, nitrates, carbs) depending on sport. They discuss EAAs, fasting, GLP-1 weight loss and lean mass loss, and Antonio’s current research on energy drinks (mostly caffeine), beta-hydroxybutyrate, and a planned creatine/eye-tracking study relevant to sports. Antonio invites listeners to the ISSN conference in Fort Lauderdale (June 17–19). 00:00 Creatine Comes Full Circle 03:56 Creatine Mainstream and Brain Dosing 05:33 Science Pragmatism Over Purism 11:17 Mechanisms Sleep and Vegans 14:40 Creatine Myths and Forms 18:00 Safety Kidneys and Liver 20:02 Simple Supplement Stack Over 40 28:27 EAAs Protein and Fasting 31:43 GLP-1s and Lean Mass Concerns 33:25 GLP-1 Lean Mass Tradeoffs 34:28 Body Positivity Backlash 35:46 Staying On Drugs Long Term 37:06 Building Exercise Habits 42:21 Health Over Vanity 42:59 Sponsor Authentic Health 44:30 Supplements Compliance Reality 48:08 Energy Drinks And BHB 49:57 Creatine For Eye Tracking 54:38 Training For Longevity 58:01 Lateral Movement And Balance 01:00:12 Conference Invite And Wrap 01:01:21 Medical Disclaimer

Hannah Anderson on MAHA, Prevention, and Cutting Through Healthcare Bureaucracy On The Healthy CEO, host Jason interviews Hannah Anderson, AFPI’s director of health policy and former deputy chief of staff for Robert F. Kennedy at HHS, about advancing MAHA from a wellness rallying cry into actionable policy. Anderson describes her Texas roots, her path into health policy, and the challenge of executing reforms inside a massive bureaucracy where incentives favor slowness and process can be used to obstruct priorities. She explains AFPI’s role in transition planning and in developing patient-first ideas, especially around prevention, wearables, and making healthcare dollars support proactive health rather than only government-defined “preventive” services under the USPSTF framework. The discussion contrasts U.S. acute-care excellence with poor prevention, critiques diagnose-and-prescribe medicine, and emphasizes practical, broadly accessible MAHA principles: solutions for everyone, realistic 70% adherence, and individual responsibility for taking back one’s health. 00:00 Welcome and Guest Intro 00:44 Sponsor Foundational Stack 02:22 Meet Hannah On Air 04:55 Texas Roots and MAHA 06:20 From Spring to DC 08:09 Making HHS About Health 13:33 Cutting Through Bureaucracy 22:24 Why She Joined AFPI 25:56 Prevention and Wearables 29:07 Obamacare Prevention Rules 29:58 Symptoms Over Root Causes 32:23 Primary Care Burnout 34:17 Prevention Versus Rescue Care 35:13 Wearables For Self Insight 37:47 CGM Sleep Food Lessons 40:25 Data Driven Prevention Policy 48:21 Making Maha For Everyone 53:21 Incentives For Healthy Metrics 55:40 Take Back Your Health 57:13 Closing And Medical Disclaimer

Healthy CEO Show: Dr. Joe Jacko on Longevity, Testosterone, and Taking Control of Your Health Host Jason Wright interviews Dr. Joe Jacko about regenerative medicine, longevity, and his critique of modern “sick care.” Jacko recounts his path from internal and sports medicine into men’s health and a concierge-style practice focused on lifestyle, hormone replacement, and comprehensive testing, arguing medical training and care are shaped by pharmaceutical funding, insurance limits, and hospital employment. They discuss testosterone therapy (targeting symptom improvement and upper-third reference ranges), common low-testosterone symptoms, and why standard primary-care labs often omit testosterone. Jacko outlines how fee-for-service restricts time and testing, contrasts it with integrated models like We Are The Armory, and explains his book, influenced by COVID-era concerns about research presentation and industry influence. Practical takeaways include prioritizing nutrition, strength training, sleep, stress management, learning, and purpose; using GLP-1s only with strength training and diet support; fasting/sauna habits; and exploring broader functional testing while avoiding overreacting to isolated abnormal results. 00:00 Show Opening 00:26 Meet Dr Joe Jocko 01:40 From Sports to Longevity 03:12 Testosterone Replacement Basics 05:06 Symptoms Over Lab Ranges 06:58 Why Primary Care Misses It 09:59 Sick Care System Origins 12:21 Fee for Service Pressures 14:31 Holistic Concierge Model 19:19 Writing Bamboozled Duped 22:53 Building Patient Agency 25:32 Natural Testosterone Boosters 28:05 Cardio Only Wakeup Call 28:41 Resistance Training For Longevity 30:41 GLP One Muscle Loss Risks 32:37 Longevity First Principles 34:48 Daily Habits Fasting Sauna 37:00 Mindset Hacks For Movement 40:00 Protein Keto And Meal Timing 41:43 Fasting As Calorie Restriction 45:29 Healthspan Thesis And Advocacy 47:52 Labs Gut Health And Testing 49:55 Where To Find Dr Jacko 50:48 Medical Disclaimer Closing

Dr. Jerry Mixon on Longevity Medicine: Hormones, Body Fat, Muscle, and Senescent Cells Dr. Jerry Mixon describes “longevity medicine” as treating aging—the progressive loss of capacity—as a medical problem focused on healthspan, not vanity. He shares that at 78 he has maintained a global hormone balance targeted to a healthy 25-year-old range for 31 years, enabling significant strength and endurance gains compared with age 50, and argues more older men should live energetic lives. Mixon emphasizes reducing excess body fat as a priority because fat acts as an inflammatory gland linked to chronic disease, while muscle acts as a healing gland producing beneficial proteins; he advocates building muscle and managing blood sugar/insulin resistance. He explains mitochondrial fragility, senescent “zombie” cells, and immune-system decline, discusses using senolytics such as dasatinib plus quercetin, and describes developing testing to measure senescent T-cell load. The conversation also covers clinic protocols, lifestyle micro-bursts of exercise, family priorities, and aligning healthcare incentives toward prevention. 00:00 Rewriting Old Age 01:46 Longevity Medicine Defined 03:24 Aging as Disease 05:05 How We Peak and Decline 06:15 What Aging Really Is 08:24 From 50 to 78 11:38 Mindset and Metrics 14:52 Start With Getting Lean 17:13 Fat vs Muscle Signals 18:56 Hormones Back to 25 20:26 Testosterone Myths 24:07 Risks and Screening 25:54 Inside the Clinic Process 29:00 Fat Inflammation Cascade 33:20 Insulin Resistance Explained 36:32 GLP-1s and Muscle 37:45 Mitochondria 101 41:14 Senescent Cell Zombies 42:41 Autophagy and Immune Cleanup 44:31 Immune System Senescence 46:10 Hormones and Senescent Load 48:54 Clearing Senescent Cells 50:33 Lifestyle Levers Exercise 53:21 Senolytics and Measuring SASP 56:54 Testing Immune Senescence 58:29 COVID and Aging Immunity 01:01:17 Personal Results and Routine 01:08:26 Family Legacy and Purpose 01:12:54 Reforming Healthcare Incentives 01:19:42 Wrap Up and Disclaimer