RECOVER-TLC released a public update on four major long COVID treatment trials. Many patients are asking the same question: how close are we to an approved treatment?

In this episode, I break down how RECOVER-TLC chooses treatments to study, why the research process takes so long, and where each of the four current trials stands right now. I’ll also explain what this progress realistically means for people living with long COVID—without hype and without false hope.

This video is for people who want a clear, honest explanation of long COVID research and timelines, and who want to understand how close—or far—we really are from approved treatments.

In this episode:
-Why approved long COVID treatments take so long
-How RECOVER-TLC selects and designs clinical trials
-Updates on baricitinib, low-dose naltrexone, GLP-1 agonists, and stellate ganglion block
-What this research means for patients right now

Chapters:
00:00 Understanding Long COVID and Research Delays
01:43 The Process of Choosing Targets
03:49 Designing Clinical Trials
07:32 Join the Community
08:25 Baricitinib
09:54 Low Dose Naltrexone (LDN)
11:08 Semaglutide: Exploring GLP-1 Treatments
14:08 Stellate Ganglion Block
16:52 Key Takeaways and Future Outlook

#longCOVID #COVID #fatigue #MECFS #POTS #medicine #science #RECOVERTLC #NIH #FDA #NIAID

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Many people with long COVID see early improvement—then hit a recovery plateau. In this episode, physician and long COVID patient Dr. Zeest Khan explains why long COVID recovery stalls and the three patterns she sees most often when progress gets stuck.

Topics covered:

• Why long COVID recovery plateaus
• The push-crash cycle and energy envelope
• Mental health, grief, and decision-making in chronic illness
• Why trying treatments at random can backfire
• How to think strategically instead of reactively

Episodes referenced:

#43: Sensory Integration Therapy for Long COVID

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For immediate crisis support in the U.S., call or text 988 to reach the Suicide & Crisis Lifeline, offering free, confidential 24/7 help for mental health, substance use, or emotional distress via call, text, or chat.

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Wondering whether to focus on treating Long COVID symptoms or finding the “root cause”? In this episode, Dr. Zeest Khan explains why chasing a cure can lead to false promises and wasted time—and why treating your most pressing symptoms is the fastest, safest way to improve quality of life. Learn how building small wins creates positive momentum, reduces hypervigilance, and empowers you to collaborate effectively with your doctors.

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This week we're sharing an episode from the archive, Dr Khan's appearance on the medical podcast "Taking Healthcare By Storm." Dr Zeest Khan tells Dr Jean Storm about her long COVID journey and the lessons she’s learned as both a physician and a patient. They discuss peer support, medical uncertainty, and why claiming your own story can transform the way you navigate chronic illness. A candid, empowering conversation.

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A quick life update.

Learn about Alice Wong: https://x.com/doctor_zeest/status/1991929577841868847?s=20

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Dr Khan interviews Dr. Julia Moore-Vogel, Scripps Researcher and lead scientist of the new study using tirzepatide to treat Long COVID. The study is called LoCITT-T, and it is actively enrolling participants. They discuss the study's design, eligibility criteria, and the potential benefits of the drug. Julia shares her personal experience with long COVID and how it has influenced her work. The conversation also covers the importance of making clinical trials accessible to those with disabilities and the innovative use of wearable technology in the study.

Keywords

Long COVID, tirzepatide, clinical trial, disability, wearable technology

Resources:

Long COVID Treatment Trial-Tirzepatide (LoCITT-T): https://www.longcovid.scripps.edu

Fatigue Severity Scale: https://www.med.upenn.edu/cbti/assets/user-content/documents/Fatigue%20Severity%20Scale%20(FSS).pdf

FUN-CAP 27: https://batemanhornecenter.org/wp-content/uploads/2023/12/FUNCAP27-questionnaire.pdf

DSQ-COVID: https://www.researchgate.net/publication/360476212_DePaul_Symptom_Questionnaire-COVID

Eric Topol, MD Ground Truths: https://erictopol.substack.com/

All of Us Research Hub: https://www.researchallofus.org/

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In this episode of Long COVID MD, Dr. Zeest Khan is joined by Katherine Marie, an nurse practitioner, long COVID patient, and podcast host. They discuss ways to navigate the holiday season while managing long COVID. They share personal experiences and strategies for maintaining health and energy, such as planning energy like a budget, setting boundaries, and building recovery time into schedules. The conversation highlights the importance of self-compassion and adapting traditions to fit current capabilities.

Hear more from Katherine Marie: https://longcovidrealtalk.com/

Keywords

Long COVID, holiday season, energy management, self-compassion, setting boundaries

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Subscribe for free written summaries of each episode, resources, and more. LongCovidMD.substack.com/subscribe

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