RNA microbiome testing reveals what DNA gut tests fundamentally miss. Your gut bacteria have 3,000+ genes each — DNA tests see zero of their actual activity. Dr. Momchilo (Momo) Vuyisich, Co-founder & CSO of Viome and former Los Alamos National Laboratory scientist, explains why RNA-based metatranscriptomics is a quantum leap over DNA sequencing for understanding your microbiome and personalizing nutrition.

Dr. Momo Vuyisich spent 12 years at Los Alamos National Laboratory developing RNA-based technology for digitizing human biology. He co-founded Viome in 2016 with Naveen Jain, and the platform has since tested 500,000+ customers across 100+ countries. His personal journey with NEU5GC autoimmune sensitivity drove his mission to replace opinion-based nutrition with data-driven, personalized recommendations.

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• DNA microbiome tests show composition only — RNA tests reveal which of 3,000+ bacterial genes are actually active
• 16S rRNA sequencing cannot distinguish pathogenic bacteria from beneficial ones
• Akkermansia can protect or destroy your gut lining depending on fiber intake and gene expression
• Carnitine supplements may cause cardiovascular disease via the TMAO pathway in certain people
• Viome's biological aging clock shows keto and paleo dieters age faster on average
• No whole food is universally good or bad — personalization requires your own molecular data
• The gut microbiome stays stable for 5-6 months; test semi-annually
• Viome currently measures 25,000 of ~100,000 biochemical reactions powering the body
• Three randomized controlled trials validate Viome's personalized nutrition approach

00:00 Introduction

02:44 Why RNA is the single best molecule to study

06:16 RNA instability — why it took 6 years to develop

08:02 Why 16S sequencing is nearly useless

11:02 Akkermansia's 3,000 genes: help or harm?

17:37 Microbiome as a dynamic self-adjusting ecosystem

23:20 NEU5GC sensitivity & mammalian food reactions

25:50 Food sensitivities (IgG) vs allergies (IgE)

29:55 Viome's 3-part approach: seal gut, reduce inflammation, personalize

41:07 Biological aging clock: keto & paleo age faster

49:13 Dry fasting crashed mitochondrial function score

52:07 Machine learning identifies metabolic bottlenecks

1:00:23 Viome measures 25% of human biology, 10% actionable

• Watch it on YouTube: https://youtu.be/bB8Zj_9pIv8
• Full episode show notes: https://outliyr.com/257

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Nick

Are you busy all day but never finishing the work that actually matters? What if the problem isn't discipline — it's that you've never learned how to enter a flow state on demand?

Steven Puri joins Nick Urban to break down the science and practice of flow states. Steven shares the exact protocol he built after two decades in Hollywood and tech: how music at 60-90 BPM triggers focus, why rain sounds outperformed $100K of custom compositions, and the morning intention habit he calls the single highest-ROI practice for productivity.

Steven Puri is the Founder and CEO of The Sukha Company, a flow state productivity platform helping knowledge workers find their focus and do their best work. Before building Sukha, Steven served as VP at 20th Century Fox running the Die Hard and Wolverine franchises, EVP at DreamWorks Pictures for Kurtzman-Orci Productions (Star Trek, Transformers), and produced CGI for 14 films including Independence Day. He sold his first tech company, Centropolis Effects, at age 28. Steven lives in Austin, TX.

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• Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more
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• Flow takes 15-23 minutes of uninterrupted focus to enter — short gaps between meetings don't count
• Music at 60-90 BPM, non-vocal, with long melodic stretches is the evidence-based sweet spot
• Rain sounds beat custom-composed focus music because they trigger unconscious memory associations
• Your physical workspace creates mental triggers — one location per type of deep work
• Before touching your phone each morning, name the ONE thing that moves your life forward
• Standard Pomodoro (25/5) often interrupts flow — try 50/10 cycles instead
• Social media platforms deploy casino game designers to maximize your time on app
• A father of two completed his PhD with just 60 focused minutes per weeknight

00:54 Steven's background: Hollywood, startups & flow state discovery

02:58 What is a flow state? Csikszentmihalyi's research explained

11:05 How "Sukha" got its name on a honeymoon in Bali

18:35 Music for flow: the 60-90 BPM sweet spot

22:32 Why rain sounds crushed $100K of custom music

29:54 Social media is engineered to steal your focus

35:27 The #1 morning habit for peak productivity

37:13 Default mode network: why great ideas come when you're not trying

42:17 Physical space = mental space (the $5 million villa story)

47:32 Time blocking & Pomodoro customization

52:05 How a dad finished his PhD in 60-minute flow sessions

• Watch it on YouTube: https://youtu.be/KhesUIwp0pI
• Full episode show notes: http://outliyr.com/256

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You don't have a motivation problem. You have a TRUST problem. And the fix is so embarrassingly simple, you'll laugh at it — but it works. Acusio Bivona lost his relationship, his business, his friends, and nearly his mind... all in 5 months.

What he built from the wreckage? A 90-day protocol that's helping founders go from total system failure to operating at a level they didn't know existed

Acusio Bivona is a Human Performance Architect and founder of The Resurrection Protocol. After 10 years as a personal trainer in Los Angeles, he experienced 5 catastrophic life events in 5 months and used the rebuilding process to design a coaching methodology for high-achieving men. His approach fuses spiritual philosophy with physiological interventions to reverse burnout and restore command-level energy.

• Outliyr Biohacker’s Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear
• Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more
• Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world
• FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus

• System failure is when health, career, relationships, and purpose break down simultaneously — and recognizing it early changes the recovery trajectory
• Unbreakable Promises are commitments so small you laugh at them, yet your brain registers the win regardless of size
• Self-trust works like a bank account: $1 deposits (kept micro-promises) compound over time into genuine confidence
• Cold Resonance removes friction instead of adding force — producing more output with zero waste, like a superconductor
• The anterior midcingulate cortex literally grows at any age when you choose voluntary discomfort
• Protocol Zero stabilizes the first 48 hours after crisis using a 7-day digital blackout and immediate Unbreakable Promises
• Start with the body — fitness delivers the most tangible, visible results and builds momentum for everything else
• 20 minutes of daily silence with zero input is one of the highest-ROI habits for self-awareness

03:05 Reframing adversity as divine intervention

06:22 Kaizen philosophy: action breeds clarity

08:52 Unbreakable Promises explained

12:03 Hot Fusion vs Cold Resonance

15:02 Why fitness is the non-negotiable first pillar

20:21 Anterior midcingulate cortex: the "do hard muscle"

25:45 Attachment theory: anxious to earned security

28:53 What system failure actually looks like

32:56 You are your own primary care doctor

34:02 Solitude, silence, and meditation twice daily

37:37 Flow state and detaching from outcomes

43:34 Protocol Zero: first 48 hours after crisis

44:47 Digital blackout: 7 days off social media

47:07 Freedom app for enforcing the blackout

• Watch it on YouTube: https://youtu.be/fwwwR6ULiSc
• Full episode show notes: http://outliyr.com/255

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Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you!

Be an Outliyr,

Nick