West Yorkshire, 1926. After completing her training in Steeple Street, Agnes is looking forward to making her mark as the village's first district nurse, confident she can make a difference in the locals' lives. But when she arrives, she's treated with suspicion, labelled just another servant of the wealthy mine owners. The locals would much rather place their trust in the resident healer, Nella Black.

Welcome to the district nurses' home on Steeple Street, where everyone has a secret.... Ambitious young nurse Agnes Sheridan had a promising future ahead of her until a tragic mistake cost her the love and respect of everyone around her. Now she has come to Leeds for a fresh start as a trainee district nurse. But Agnes finds herself facing unexpected challenges as she is assigned to Quarry Hill, one of the city's most notorious slums.

Hull, 1940. Widowed Edie Copeland has just arrived on Exchange Street, heavily pregnant and with heavy suitcase in tow. She left York after tragedy struck to make a fresh start, but she's a stranger to this street, and her new landlord doesn't hesitate to remind her of this, widow or not. Luckily, the neighbours are a little more welcoming and Edie is soon made to feel at home by the Maguires and the Scuttles. As air raids sound and the war feels closer than ever, the community has to stick together. But Edie is hiding something, and she doesn't know how much longer her secret is safe.

Mary Vale, a grand and imposing Mother and Baby Home, sits on the remote Fylde coast in Lancashire. Its doors are open to unmarried women who come to hide their condition and find sanctuary. Women from all walks of life pass through Mary Vale, from beautiful waitress Emily, whose boyfriend has vanished without trace, to young Isla, cast out by her wealthy family after her first year at university goes horribly wrong. Awaiting them is Nurse Ada and Sister Anne who work tirelessly to aid the mothers and safely deliver the babies. 

The East End of London has been devastated by the Blitz and the people are struggling to come to terms with their ravaged city. Rationing bites ever deeper, and and everything that makes life better is in short supply. For the district nurses, the challenges are tougher than ever. Gladys loves her work in the Civil Nursing Reserve, but just when she needs to rely on her sister at home to help out with the chores, she turns into a handful of trouble. Edith is learning to cope with her boyfriend's injuries after Dunkirk but will she have to choose between her love for him and her career?

When sixteen-year-old Sally is evacuated to the English south coast, she is terrified by what lies ahead of her. All she knows are the sights and sounds of London's East End – but Sally swallows her tears as they leave the familiar landmarks behind, knowing that she has to be a Grown-Up Girl and play mother to her six-year-old brother Ernie. Playing mother is nothing new for Sally – their real mother Florrie, a good-time girl, hasn't even come to the station to wave them off and Ernie, crippled at an early age by polio, is used to depending on his older sister.

It is 1953, and five girls are arriving to start their training at St Angelus Hospital. Dana has escaped from her family farm in Ireland. Victoria is running away from an aristocratic background. Beth is an army brat and throws her lot in with bitchy Celia Forsyth, and Pammy has come from the wrong side of the tracks. When an unknown girl is admitted after a botched backstreet abortion, a tragedy begins to unfold which will rock the world of St Angelus to its foundations.

It wasn't a privileged childhood, but it was a happy one. Sybil and Lizzie Cream, brought up in a fisherman's cottage on the edge of the cold North Sea, were content to leave privilege where it belonged: with their friends the Wintertons. Christina Winterton was the same age as Sybil, and the two girls were inseparable, but it was Lizzie whom Ralph Winterton, three years older, found irresistible. Then war came to East Anglia, and so did Manchester-born Fenn Kitzmann, now of the American Army Air Force.

After the heartbreak of World War Two, newlywed midwife Cathy hoped Liverpool life would offer some joy. But a terrible miscarriage and the escape of her abusive stepfather Jack from prison make happiness hard to find. Meanwhile, Cathy’s beloved granny is ailing. Whilst at the hospital, Cathy sees her midwifery friends, who are planning to open a home for unmarried mothers. After losing a baby of her own, Cathy would love to help, but for now, she must take care of her grandmother.  

August 1940: As the Luftwaffe swarm over Liverpool, Shane Quinn decides to move his family back to the safety of Ireland. But his only child, the beautiful Dana, would rather stay and serve her country than flee to a foreign land. Determined to make it on her own, she joins the WAAF with newfound pals Patty and Lucy. There’s plenty of excitement to be had on a RAF station, even a chance or two at love.

Set in 1920s London, this is the inspiring story of Kate Goss' struggle against poverty, hunger and cruel family secrets. Her mother died in a fall, her father has vanished without trace, and now her aunt and cousins treat her viciously. In a freezing, vermin-infested garret, factory girl Kate has only her own brave spirit and dreams of finding her father to keep her going. She has barely enough money to feed herself, or to pay the rent. The factory where she works begins to lay off people and it isn't long before she has fallen into the hands of the violent local money-lender. 

Meet The East End Angels, the newest members of Station Seventy-Five's ambulance crew. Strong-willed Winnie loves being part of the crew at Station Seventy-Five, but her parents are less than happy. She has managed to avoid their pleas to join the WRENS so far, but when a tragedy hits too close to home she finds herself wondering if she's cut out for this life after all. Former housemaid Bella was forced to leave the place she loved when she lost it all, and it's taken her a while to find somewhere else to call home. She's finally starting to build a new life, but when the air raids begin, it seems she may have to start over once again.

Sunderland, 1940, and the women go to the shipyards to do their bit for the war effort. Polly never dreamed she would be able to work in the shipyards like the men in her family but times are tough and her new job ends up giving her more than she ever expected when she meets enigmatic dock diver Tommy Watts. During the day, head welder Rosie teaches her fledgling flock of trainees their new trade, but at night she hides a secret life. And mother hen Gloria signs up to escape her brutal husband, but finds she cannot run....

One wild night in the 1930s, midwife Patty Peel is called to attend a birth on the opposite side of Liverpool. She pedals off into the storm and delivers a baby girl in a filthy slum dwelling, just as the mother dies. The drunk and violent father tells Patty to get rid of it so she takes the child away, meaning to deliver it to the nearest orphanage. However, Patty spent her entire childhood in an institution, except for the frequent occasions when she ran away, and cannot bear to hand the baby over. 

1940, Liverpool: Alice Turner and her best friend, Millie Markham, work for the war effort at Rootes munitions factory, making shell caps and Halifax bombers. Alice’s sweetheart, Terry, is home from the front for a brief period of leave. But the honeymoon is soon over. Terry must go back to the dangers of Nazi-occupied France, and the ever-present air raid sirens quickly bring Alice back down to earth.