To the student nurses at The Nightingale hospital, the ward sisters are heartless and frightening, with impossibly high standards. But the sisters have troubles of their own...Dora, the student nurse is struggling with her heartbreak over Nick, the man who got away. A new arrival on the ward brings the chance to put a smile back on her face. But can she really get over Nick so easily? Dora's fellow student Millie is also torn between the two men in her life.

It's the final year of training for three young nurses at The Nightingale Hospital. Helen is at a crossroads in her life as she battles with her domineering mother over both her love life and her future career. Dora can't stop loving Nick, who is married to her best friend, Ruby. Millie is anxious about her fiancé, sent to Spain to cover the Civil War, and things only get worse when she encounters a fortune teller who gives her a sinister warning.

Dora and her old enemy Lucy are paired up on the children's ward for the final three months of their training. The two nurses couldn't seem more different, but they may have more in common than they think, as each hides a secret heartache. And there are new faces. Jess is the feisty eldest daughter of a notorious East End family and determined to prove herself as a ward maid. New trainee nurse Effie can't wait to escape her small Irish village, and make her way as a nurse in London.

As Christmas 1938 approaches, the staff at the Nightingale Hospital have their own wishes for the festive season. Ward sister Frannie Wallace is hoping she won't have to live through another war like the one that claimed her fiance. Staff Nurse Helen Dawson wants to find happiness again after the death of her husband Charlie. But is she looking for love in the wrong place? Matron Kathleen Fox struggles to keep up morale.

It's Christmas 1941, and the nurses at the Nightingale are facing their toughest winter yet. With shortages everywhere and every news bulletin announcing more losses, the British people are weary and demoralised, and The Nightingale Hospital is suffering too. Millie is recently widowed and dealing with the demands of her family's estate. It's not long before her old world of the Nightingale begins to beckon, along with a long-lost love.... Jess is struggling with her move from East London to the countryside.

With her husband, Nick, away fighting, Dora struggles to keep the home fires burning but finds herself in a difficult position when she is put in charge of a ward of injured German POWs. Can she find it in her heart to care for her enemies? Fellow nurse Kitty faces a similar struggle looking after the men who killed her beloved brother. But her life becomes even more complicated when she falls for one of the prisoners. And Helen Denton returns from nursing in Europe with a secret. She has her own reasons for hating the Germans.

Matron Kathleen Fox has the job of putting the hospital back together but wonders if she is up to the task. In an attempt to bring some festive cheer, she decides to put on a Christmas show. The idea is greeted with mixed feelings by the nurses, who all have their own problems, and also by the new Assistant Matron and ward sister, who find themselves rivals for the role of organiser. But as rehearsals begin, the performers begin to find the show is not just a tonic for the patients.

London, 1914. While young men enlist up and down the country, the Nightingale Hospital has its own set of new recruits.... Anna Beck is the daughter of the best baker in Bethnal Green. Her German father built the business out of nothing, but as the shadow of war descends, his fate is at the mercy of their neighbours. Meanwhile Katie Carlyle has always wanted to become a doctor. She fought hard to get into medical school, and even now she faces prejudice from her fellow students as well as the tutors. Can she prove them wrong?

Welcome to the district nurses' home on Steeple Street, where everyone has a secret.... Ambitious young nurse Agnes Sheridan had a promising future ahead of her until a tragic mistake cost her the love and respect of everyone around her. Now she has come to Leeds for a fresh start as a trainee district nurse. But Agnes finds herself facing unexpected challenges as she is assigned to Quarry Hill, one of the city's most notorious slums.

Anna is over the moon when her sweetheart returns from the front line. As he recovers from his injuries, they make plans to be married, but the horrors of the trenches cast a long shadow. Caring for shell-shocked soldiers brings untold challenges for Grace, and her parents have very different dreams for her future. Meanwhile Dulcie has her sights firmly set on her own happy ending. And yet sometimes we find love where we least expect to. Each of the nurses has her own battle to fight, but they must rally together if they’re to find true happiness.

Christmas Eve, 1936. On a foggy December night, a pregnant woman walks out in front of a trolley bus and is knocked unconscious. She is rushed to the Nightingale hospital, and a healthy baby is delivered. But the mother claims to have lost her memory, and cannot believe that the child is hers. It seems that the Nightingale nurses may need to perform a Christmas miracle.

Spring, 1941. The families of Jubilee Row are still reeling from the loss of one of their own, and as the Blitz on Hull intensifies, it seems as if there will be more tragedies to come. As the street braces itself, capable mum Ruby Maguire takes charge as usual, bolstering spirits and lending a hand, as well as keeping her flighty sister Pearl on the straight and narrow. But the unexpected appearance of a face from her past threatens Ruby's future far more than Hitler's bombs. Meanwhile, the other inhabitants of Jubilee Row are finding love - and hope - in the most unexpected places.

Hull, 1940. Widowed Edie Copeland has just arrived on Exchange Street, heavily pregnant and with heavy suitcase in tow. She left York after tragedy struck to make a fresh start, but she's a stranger to this street, and her new landlord doesn't hesitate to remind her of this, widow or not. Luckily, the neighbours are a little more welcoming and Edie is soon made to feel at home by the Maguires and the Scuttles. As air raids sound and the war feels closer than ever, the community has to stick together. But Edie is hiding something, and she doesn't know how much longer her secret is safe.

Cathy was a happy, blushing bride when Britain went to war with Germany three years ago. But her youthful dreams were crushed by her violent husband, and even when he’s conscripted she knows it’s only a brief respite - divorce is not an option. Cathy, a true Brogan daughter, stays strong for her beloved little son, Peter. When her husband is declared missing in action, Cathy can finally allow herself to hope - in just 6 months she will legally be a widow. In the meantime, she has to keep Peter safe and fed. 

In the drab Yorkshire town of Garsthwaite, Lacey Barraclough works hard in the textile mill, determined to fight for improvements to the dismal working conditions. But she hadn't reckoned on falling in love with the boss' son, Nathan. Before Nathan and Lacey can make a life together, World War I breaks out and Nathan enlists to fight. When Nathan heads off to the Front, Lucy must find a new way to face the future. As hard times come to Garsthwaite, will there be a home for the returning heroes to come back to?