Why GLP-1 Withdrawal Trials Fail — and Why Cardiometabolic Care Must Look Different
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Why GLP-1 Withdrawal Trials Fail — and Why Cardiometabolic Care Must Look Different
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A 2026 BMJ systematic review confirms that weight regain is the rule after stopping pharmacological weight-management therapy. Across drug classes, most lost weight is regained within 24 months, with parallel loss of metabolic benefit. This reflects biological defence of adiposity, not patient failure.
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