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What's Up Docs?

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About this listen

In this BBC Radio 4 podcast, Drs Chris and Xand van Tulleken are on a mission to help us take better care of ourselves.

Although they are identical twins, Chris and Xand are very different and they never stop thinking and arguing about science and health. They want to lead healthy, happy lives and as doctors, they want this for everyone. Yet they tussle over how best to get there.

When it comes to looking after our own health, it can be confusing. Medicine and science produce amazing new treatments and diagnostics every day and we are bombarded with so many headlines and pieces of advice; but how are we supposed to know what's really best for us and then successfully apply it to our lives?

Drs Chris and Xand van Tulleken embrace this challenge; even as they marvel at the scientific breakthroughs, they grapple with the competing claims about health, wellbeing and how to live.

From understanding testosterone therapies to microplastics in our diets, and the concept of 'hangriness' to the power of saying no - this podcast deals with the health stresses we all face every day, while taking on board how the decisions by corporations and governments affect all our health.

Each episode, Chris and Xand are joined by an expert guest to examine the latest research, psychological insights, and data, to help listeners navigate the overwhelming amount of information and advice out there. They talk about the trials and tribulations in their own lives in their characteristically witty way - each teasing the other as they search for solutions. Xand has trouble sleeping , Chris has noisy knees, one of them has got an embarrassing itch. They have different ways of looking at things and find it really helpful to get the other one's point of view. These doctors are trying their best and encouraging listeners to do the same.

Email: whatsupdocs@bbc.co.uk Whatsapp: 08000 665123

A Loftus Media production for BBC Radio 4.

(C) BBC 2025
Biological Sciences Hygiene & Healthy Living Science
Episodes
  • Doctors' Notes: Dopamine
    Dec 9 2025

    Chris and Xand continue their conversation about dopamine with Masud Husain, Professor of Neurology & Cognitive Neuroscience at the University of Oxford. They explore how he first became interested in dopamine, what happens when dopamine systems become overactive, underactive, or disrupted, and whether we have any real control over our dopamine at all. Masud also shares the one thing he wishes everyone understood about dopamine.

    If you’d like to share your thoughts on this or any other topic covered on the podcast, you email us at whatsupdocs@bbc.co.uk or Whatsapp on 08000 665 123.

    Presenters: Drs Chris and Xand van Tulleken Guest: Professor Masud Husain Producer: Maia Miller-Lewis Executive Producer: Rami Tzabar Editor: Jo Rowntree Researcher: Grace Revill Tech Lead: Reuben Huxtable Social Media: Leon Gower Digital Lead: Richard Berry Composer: Phoebe McFarlane Sound Design: Melvin Rickarby

    At the BBC: Assistant Commissioner: Greg Smith Commissioning Editor: Rhian Roberts

    A Loftus Media production for BBC Radio 4.

    Show More Show Less
    22 mins
  • Can you be ‘addicted to dopamine’?
    Dec 9 2025

    Welcome to What’s Up Docs?, the podcast where doctors and identical twins Chris and Xand van Tulleken untangle the confusion around every aspect of our health and wellbeing.

    In this episode, they’re diving into dopamine – one of the most talked-about chemicals in modern wellness culture. But what is dopamine, really? What role does it play in pleasure, motivation, learning, and movement? And how accurate are ideas like “dopamine hits”, “dopamine detoxes”, or being “addicted to dopamine”?

    Chris and Xand speak to Masud Husain, Professor of Neurology & Cognitive Neuroscience at the University of Oxford, to cut through the myths and find out what dopamine does, what it doesn’t do, and why understanding it properly might change the way we think about our behaviour and our brains.

    If you want to get in touch, you can email us at whatsupdocs@bbc.co.uk or WhatsApp us on 08000 665 123.

    Presenters: Drs Chris and Xand van Tulleken Guest: Professor Masud Husain Producer: Maia Miller-Lewis Executive Producer: Rami Tzabar Editor: Jo Rowntree Researcher: Grace Revill Tech Lead: Reuben Huxtable Social Media: Leon Gower Digital Lead: Richard Berry Composer: Phoebe McFarlane Sound Design: Melvin Rickarby

    At the BBC: Assistant Commissioner: Greg Smith Commissioning Editor: Rhian Roberts

    A Loftus Media production for BBC Radio 4

    Show More Show Less
    29 mins
  • Doctors' Notes: Beliefs
    Dec 2 2025

    Chris and Xand continue their conversation about belief with Ryan McKay, Professor of Psychology at Royal Holloway, University of London.

    They want to know why some beliefs take hold so strongly, what’s happening in our brains when we hold on to them, and how trust, identity, and community shape what we believe. Beyond that, they’ll explore why health beliefs can be so difficult to shift, and whether it’s ever really possible to change someone’s mind. From the psychology of delusions to the spread of everyday health narratives, this episode dives deeper into the mechanics of belief.

    If you’d like to share your thoughts on this or any other topic covered on the podcast, you email us at whatsupdocs@bbc.co.uk or Whatsapp on 08000 665 123.

    Presenters: Drs Chris and Xand van Tulleken Guest: Professor Ryan McKay Producer: Maia Miller-Lewis Executive Producer: Rami Tzabar Editor: Jo Rowntree Researcher: Grace Revill Tech Lead: Reuben Huxtable Social Media: Leon Gower Digital Lead: Richard Berry Composer: Phoebe McFarlane Sound Design: Melvin Rickarby

    At the BBC: Assistant Commissioner: Greg Smith Commissioning Editor: Rhian Roberts

    A Loftus Media production for BBC Radio 4

    Show More Show Less
    20 mins
All stars
Most relevant
Really enjoy listening to these two. Both relatable and interesting at the same time.

Fab

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I was enjoying this podcast. I always enjoy the tullekan brothers information. unfortunately wither it is audible, them or bbc I dont know but needing to use 1 credit for less 30 minute listen is not viable. I would never be able to listen to any books and would take 2 months to listen to 1 episode and the additional notes. disappointing move - sadly wont be able to listen anymore.

disappointed this is now locked on audible

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