Access the mentioned paper here:

Trying to Unravel Why Alzheimer Disease Is More Common in Women

By Rita Rubin, MA

https://jamanetwork.com/journals/jama/article-abstract/2839498#

Access mentioned courses here:

Women’s Mental Health Course:

https://psychscene.co/41RwJx2

Alzheimer’s Disease Course:

https://psychscene.co/4vNaeqH

In this episode, Dr Sanil Rege examines why Alzheimer’s disease is more common in women and what this means for clinical assessment, prevention, and treatment.

The discussion reviews a 2025 JAMA medical news feature (https://jamanetwork.com/journals/jama/article-abstract/2839498#) on sex differences in Alzheimer’s disease and outlines a life-course model showing how sex-related vulnerability may shape disease onset, progression, and clinical expression.

This video provides clinicians with a sex-informed clinical framework for assessing Alzheimer’s risk in women through the lens of hormonal transitions, cognitive reserve, and later-life neurodegenerative expression.

Chapters:

00:21 Alzheimer’s Disease in Women

02:59 Beyond Longevity

03:40 Survival Differences After Dementia Diagnosis

04:34 Tau Pathology and Steeper Later Decline

06:00 Menopause and Hormonal Vulnerability

08:11 Modifiable Midlife Risk Factors in Women

13:18 A Sex-Informed Life-Course Formulation1

#Alzheimer's #Psychiatry #Dementia

Here are the links to the papers mentioned:

Parkinson’s disease as a somato-cognitive action network disorder

Ren et. al.

https://psychscene.co/4vQKgmc

The brain’s action-mode network

Dosenbach et. al.

https://psychscene.co/4ts1pRr

Access mentioned courses here:

Advanced Psychiatric Formulation and Strategic Management:

https://psychscene.co/4sG214L

ADHD Masterclass:

https://psychscene.co/4sJ1GOS

In this video, Dr Sanil Rege examines the Action Mode Network as a unifying clinical framework for understanding how the brain regulates action, arousal, body state, and cognition.

He explores the counterbalance between action mode and default mode, showing how impaired initiation, hyperarousal, poor state shifting, and social withdrawal may be better understood as disturbances of mode regulation rather than isolated symptom categories.

This session provides clinicians with a neurobiological framework for refining psychiatric formulation through the lens of state regulation, brain–body integration, and network-based clinical reasoning.

Chapters:

01:32 – Introducing the Action Mode Network

03:17 – The Brain as an Organ Organised for Action

05:48 – Action Mode vs Default Mode

07:18 – Psychiatric Syndromes as Mode-Switching Disorders

09:48– Overcoming the False Dichotomy of Mind and Body

12:25 – The PACES Model in Clinical Formulation

14:48 – Translating State Regulation into Clinical Practice

#ActionModeNetwork #Psychiatry #Brain

Access the mentioned courses here:

Sleep And Psychiatry:

https://psychscene.co/46d0T09

ADHD and Sleep Dysfunction:

https://psychscene.co/4rrE9Cc

In this episode, Dr Sanil Rege explores the "how and why" of sleep by analysing a 2025 Neuron perspective paper (https://pubmed.ncbi.nlm.nih.gov/40961940/) detailing the interplay between sleep, motor circuits, and catecholamine biology.

The discussion unpacks the motor theory of sleep, in which sleep control is embedded within somatic and autonomic motor circuits, and the catecholamine hypothesis, which posits that a core biological function of sleep is the inactivation of dopamine, noradrenaline, and adrenaline.

This podcast provides clinicians with a neuroscientific framework for understanding sleep as an active state transition involving a global downshift of somatic and autonomic motor systems.

#Sleep #Neuropsychiatry #Insomnia