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Normal Curves: Sexy Science, Serious Statistics

Normal Curves: Sexy Science, Serious Statistics

By: Regina Nuzzo and Kristin Sainani
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About this listen

Normal Curves is a podcast about sexy science & serious statistics. Ever try to make sense of a scientific study and the numbers behind it? Listen in to a lively conversation between two stats-savvy friends who break it all down with humor and clarity. Professors Regina Nuzzo of Gallaudet University and Kristin Sainani of Stanford University discuss academic papers journal club-style — except with more fun, less jargon, and some irreverent, PG-13 content sprinkled in. Join Kristin and Regina as they dissect the data, challenge the claims, and arm you with tools to assess scientific studies on your own.© 2025 Regina Nuzzo & Kristin Sainani Science Social Sciences
Episodes
  • Bonus: Vitamin D Part 1 with commentary
    Dec 29 2025
    While we’re on a short break between seasons, we’re revisiting some of our favorite episodes from Season 1. This week, we’re re-releasing our deep dive into vitamin D and the origins of the so-called deficiency epidemic, with added commentary.Is America really facing an epidemic of vitamin D deficiency? While this claim is widely believed, the story behind it is packed with twists, turns, and some pesky statistical cockroaches. In this episode, we’ll dive into a study on Hawaiian surfers, expose how shifting goalposts can create an epidemic, tackle dueling medical guidelines, and flex our statistical sleuthing skills. By the end, you might wonder if the real deficiency lies in the data.Statistical topicsconflicts of interestcut points and thresholdsdichotomizationincentives in sciencemeasurement and classificationnormal distribution researcher biasesstandard deviationstatistical sleuthingMethodologic morals“Arbitrary thresholds make for arbitrary diseases.”“Statistical errors are like cockroaches: Where there’s one, there’s many.”Note that all blood vitamin D levels discussed in the podcast are 25-hydroxyvitamin D levels given in units of ng/ml. To convert from ng/ml to nmol/L, use the formula: nmol/L=2.5*ng/ml. For example, a vitamin D level of 30 ng/mL corresponds to 75 nmol/L.CitationsDr. Rhonda Patrick: Micronutrients for Health & Longevity. Huberman Lab Podcast. May 1, 2022Noh CK, Lee MJ, Kim BK, et al. A Case of Nutritional Osteomalacia in Young Adult Male. J Bone Metab. 2013; 20:51-55.Binkley N, Novotny R, Krueger D, et al. Low vitamin D status despite abundant sun exposure. J Clin Endocrinol Metab. 2007;92:2130-5. Malabanan A, Veronikis IE, Holick MF. Redefining Vitamin D Insufficiency. Lancet. 1998;351:805-6. Dawson-Hughes B, Heaney RP, Holick MF, et al. Estimates of optimal vitamin D status. Osteoporos Int. 2005;16:713-6.Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266-81.Cui A, Xiao P, Ma Y, et al. Prevalence, trend, and predictor analyses of vitamin D deficiency in the US population, 2001-2018. Front Nutr. 2022;9:965376. Ross AC, Manson JE, Abrams SA, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;96:53-8. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2011;96:1911-30. Manson JE, Brannon PM, Rosen CJ, et al. Vitamin D deficiency-is there really a pandemic. N Engl J Med. 2016;375:1817-20. Conti G, Chirico V, Lacquaniti A, et al. Vitamin D intoxication in two brothers: be careful with dietary supplements. J Pediatr Endocrinol Metab. 2014;27:763-7.Holick, Michael, et al. The UV Advantage. Ibooks, 2004.Holick, Michael F. The Vitamin D Solution: A 3-Step Strategy to Cure Our Most Common Health Problems. Penguin Publishing Group, 2011.Szabo, Liz. Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It. The New York Times. August 18, 2018.Lee JM, Smith JR, Philipp BL, Chen TC, Mathieu J, Holick MF. Vitamin D deficiency in a healthy group of mothers and newborn infants. Clin Pediatr. 2007;46:42-4. Holick MF. Vitamin D deficiency: what a pain it is. Mayo Clin Proc. 2003;78:1457-9.Passeri G, Pini G, Troiano L, et al. Low Vitamin D Status, High Bone Turnover, and Bone Fractures in Centenarians. J Clin Endocrinol Metab. 2003;88:5109-15. Armstrong, David. The Child Abuse Contrarian. ProPublica. September 16, 2018.Irwig MS, Kyinn M, Shefa MC. Financial Conflicts of Interest Among Authors of Endocrine Society Clinical Practice Guidelines. J Clin Endocrinol Metab. 2018;103:4333-38. Demay MB, Pittas AG, Bikle DD, et al. Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2024;109:1907-47.McCartney CR, McDonnell ME, Corrigan MD, et al. Vitamin D Insufficiency and Epistemic Humility: An Endocrine Society Guideline Communication. J Clin Endocrinol Metab. 2024; 109:1948–54.See our detailed notes hereKristin and Regina’s online coursesDemystifying Data: A Modern Approach to Statistical Understanding Clinical Trials: Design, Strategy, and AnalysisMedical Statistics Certificate Program Writing in the SciencesEpidemiology and Clinical Research Graduate Certificate ProgramPrograms that we teach in:Epidemiology and Clinical Research Graduate Certificate Program Find us on:Kristin - LinkedIn & Twitter/XRegina - LinkedIn...
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    1 hr and 29 mins
  • The Batman Effect: Do weird surprises make people nicer?
    Dec 15 2025

    Description

    Nobody expects Batman—but when he shows up in a crowded subway car, are people suddenly more likely to help a passenger in need? This week on Normal Curves, we unpack a recent quasi-experimental field study involving a caped superhero costume, a prosthetic pregnancy belly, and some puzzled Italian commuters. Along the way, we demystify three common ways of describing effects for binary outcomes—risk differences, risk ratios, and odds ratios—and explain what they actually mean in plain language. We also do some statistical sleuthing, uncover a major problem hiding in the paper’s numbers, and debate what really counts as an effective Batman outfit.



    Statistical topics

    • absolute vs relative effects
    • binary outcomes
    • coding errors
    • data errors and quality control
    • effect size interpretation
    • field experiments
    • odds
    • odds ratios
    • percentage differences
    • quasi-experimental studies
    • risk differences
    • risk ratios
    • statistical sleuthing

    Methodological morals

    • “We love an uncluttered paper, but when it's missing the basics, it's like an empty fridge. Clean, yes, but dinner is not happening.”
    • “Before you make a fancy model, make sure the numbers in the table in the text match.”


    References

    • Pagnini F, Grosso F, Cavalera C, et al. Unexpected events and prosocial behavior: the Batman effect. Npj Ment Health Res. 2025;4(1):57. Published 2025 Nov 3. doi:10.1038/s44184-025-00171-5
    • PubPeer. Comments on “Unexpected events and prosocial behavior: the Batman effect.” Accessed December 2025.
    • Sainani KL. Understanding odds ratios. PM R. 2011;3(3):263-267. doi:10.1016/j.pmrj.2011.01.009
    • Nuzzo RL. Communicating measures of relative risk in plain English. PM R. 2022;14(2):283-287. doi:10.1002/pmrj.12761
    • Sainani KL. How statistics can mislead. Am J Public Health. 2012;102:e3-4.



    Kristin and Regina’s online courses:

    Demystifying Data: A Modern Approach to Statistical Understanding

    Clinical Trials: Design, Strategy, and Analysis

    Medical Statistics Certificate Program

    Writing in the Sciences

    Epidemiology and Clinical Research Graduate Certificate Program

    Programs that we teach in:

    Epidemiology and Clinical Research Graduate Certificate Program


    Find us on:

    Kristin - LinkedIn & Twitter/X

    Regina - LinkedIn & ReginaNuzzo.com


    • (00:00) - Intro
    • (03:42) - Why would Batman make people nicer?
    • (07:33) - How they ran the experiment
    • (17:50) - Did Batman save the day? Different ways to answer that
    • (23:00) - What are odds and odds ratios?
    • (30:00) - Where people get it wrong
    • (34:52) - The plot twist: big numerical errors
    • (41:20) - Did men or women give up their seat more often?
    • (43:49) - Wrap-up and methodological morals


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    47 mins
  • Holiday Survival Guide Part 2: The survey study edition
    Dec 1 2025

    Does the temperature of your coffee six months ago really predict whether you feel gassy today? This week we dissect a new nutrition survey study on hot and cold beverage habits that claims to connect drink temperature with gut symptoms, anxiety, and more—despite relying on year-old memories and a blizzard of statistical tests. It’s the perfect case study for our Holiday Survival Guide Part 2, where we teach you how to talk with Uncle Joe at the dinner table about one of the most common—and most fraught—study designs in science: cross-sectional surveys. We walk through our easy checklist for making sense of results, show how recall bias and measurement error can skew the story, and reacquaint you with nonmonogamous Multiple-Testing Dude, who’s been very busy in this dataset. A friendly, practical guide to spotting when researchers are just torturing the data until it confesses.


    Statistical topics

    • Confounding
    • Cross-sectional studies
    • False positives
    • Measurement error
    • Multiple testing
    • PICOT / PIVOT framework
    • Recall bias
    • Research hypotheses
    • Sample size and power
    • Signal vs. noise
    • SMART framework
    • Statistical significance
    • Subgroup analyses
    • Survey design
    • Transparency and trustworthiness


    Methodological morals

    • “When your measurement starts with ‘think back to last winter’ you might as well use a random number generator.”
    • “If the effect is only significant in certain subgroups in certain seasons for certain outcomes, it might just be a bad case of gas.”



    References

    • Wu T, Doyle C, Ito J, et al. Cold Exposures in Relation to Dysmenorrhea among Asian and White Women. Int J Environ Res Public Health. 2023;21(1):56. Published 2023 Dec 30. doi:10.3390/ijerph21010056
    • Wu T, Ramesh N, Doyle C, Hsu FC. Cold and hot consumption and health outcomes among US Asian and White populations. Br J Nutr. Published online September 18, 2025. doi:10.1017/S000711452510514X



    Kristin and Regina’s online courses:

    Demystifying Data: A Modern Approach to Statistical Understanding

    Clinical Trials: Design, Strategy, and Analysis

    Medical Statistics Certificate Program

    Writing in the Sciences

    Epidemiology and Clinical Research Graduate Certificate Program

    Programs that we teach in:

    Epidemiology and Clinical Research Graduate Certificate Program


    Find us on:

    Kristin - LinkedIn & Twitter/X

    Regina - LinkedIn & ReginaNuzzo.com


    • (00:00) - Intro
    • (04:36) - Did they have real research hypotheses?
    • (10:29) - Observational or randomized experiment?
    • (20:09) - PICOT and PIVOT
    • (26:20) - Memory problems
    • (32:03) - Five outcomes and measurement problems therein
    • (36:56) - SMART
    • (41:50) - Multiple Testing Dude is having a great time
    • (52:36) - How big is the effect?
    • (59:06) - Wrap-up and Irish Coffee rating scale

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    1 hr and 4 mins
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