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The Saving Dose

The Saving Dose

By: John Hsu Kendra Allen William Pedranti
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The podcast for those building the future of healthcare. A clinician, a healthcare attorney, and a behavioral health executive on what's actually working in addiction, adherence, and the capital reshaping both.


75% of patients do not take medications as prescribed. 125,000 Americans die from it every year. $528 billion in preventable costs trace directly to a gap the healthcare system has known about for decades and never closed: what happens after the prescription is written.

The Saving Dose is a podcast about that gap, the space between the clinic visit and the outcome, between the evidence-based treatment and the patient who never receives it, between the innovation that works and the reimbursement system that decides whether anyone can afford to deliver it.

Hosted by Kendra Allen, Dr. John Hsu, and William Pedranti, the show brings together a behavioral health revenue strategist, an addiction medicine physician, and a biotech entrepreneur to go inside the clinical, operational, and commercial realities of addiction recovery, medication adherence, opioid use disorder (OUD), and behavioral health. Three different vantage points on the same broken system. Honest about what fails, specific about why, and direct about what a real fix requires.

Topics include: MOUD and MAT clinic operations, medication-assisted treatment adherence, behavioral health reimbursement, opioid use disorder treatment, payer contracting, DEA compliance, FFS-to-value-based care transitions, and the patient adherence gap in controlled substance prescribing.

The Saving Dose is for investors evaluating the addiction recovery and behavioral health infrastructure market. For clinic operators and executives running opioid treatment programs, MOUD practices, and behavioral health facilities. For clinicians in addiction medicine and pain management. For payers and administrators navigating the cost and risk of behavioral health coverage.

New episodes every two weeks. Available on Spotify, Apple Podcasts, YouTube, and wherever you listen.


© 2026 The Saving Dose
Episodes
  • Why Addiction Treatment Is Failing America | The Saving Dose Ep. 01

    Why Addiction Treatment Is Failing America | The Saving Dose Ep. 01
    May 21 2026

    In the first episode of The Saving Dose, three addiction medicine and behavioral health executives discuss why opioid use disorder treatment is failing patients, what the medication adherence gap actually looks like from inside the clinic, and what it will take to fix it. Topics include MOUD access, buprenorphine barriers, pain management misconceptions, behavioral health revenue challenges, and the infrastructure gap driving medication non-adherence across America.

    This episode covers who they are, what brought them to this space, and why they believe the addiction treatment system is failing not because the science is missing, but because the infrastructure to deliver it consistently has never been built.

    In this episode:

    Why John Hsu MD walked away from a traditional anesthesiology career to build a medication security company, and the moment in his own clinic that made it impossible not to.

    What William Pedranti learned after 20 years building biotech companies about the gap between clinical evidence and real-world patient outcomes, and why addiction treatment has the widest gap he has ever seen.

    What Kendra Allen saw working on the frontlines of behavioral health, and why patients in active recovery were losing access to treatment not because they stopped trying, but because the system stopped making it possible.

    The parking lot: what John's patients were doing before their appointments, and what it told him about the failure of in-home medication management.

    The access problem in a single number: over 50% of patients can be saved by taking their medications consistently. Only 25% of them can access those medications.

    Why every person William tells about iPill responds the same way, and what that says about how close this crisis is to every family in America.

    What recovery actually requires: medication, consistency, and a system that does not make patients fight for both every single day.

    About the Hosts

    John Hsu, MD is the Founder and CEO of iPill and a practicing anesthesiologist with 25 years in pain management and addiction medicine. He has taken multiple products through FDA approval and commercial launch. Connect with John: https://www.linkedin.com/in/john-hsu-md-300a8b2a/

    William Pedranti is the COO of iPill, a Georgetown Law graduate, and co-founder of PENG Life Science Ventures. He has taken a biotech company from founding through FDA approval, commercial launch, and exit. Connect with William: https://www.linkedin.com/in/williampedranti/

    Kendra Allen is the CRO of iPill with 20 years in behavioral health revenue strategy, payer contracting, and regulatory navigation. She founded and exited a national healthcare consulting firm. Connect with Kendra: https://www.linkedin.com/in/kendra-allen-cro/

    Website: thesavingdose.com

    Disclaimer: This podcast is for educational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before making any treatment decisions.

    #OpioidCrisis #AddictionRecovery #OpioidUseDisorder #MedicationAdherence #MOUD #BehavioralHealth #AddictionMedicine #PainManagement #SubstanceUseDisorder #HealthcarePodcast #TheSavingDose #MentalHealth #RecoveryPodcast #OpioidTreatment #PublicHealth
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    32 mins
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