How One Amino Acid Touches Two Aging Pathways
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How One Amino Acid Touches Two Aging Pathways
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About this listen
L-arginine is usually treated as a simple nitric-oxide precursor, a molecule with a narrow vascular role. But across multiple lines of research, it keeps appearing in places it shouldn’t: improving cerebral blood flow in older adults, shifting cognitive performance, and, most unexpectedly, altering how amyloid-β proteins aggregate in the brain. This episode unpacks why these effects are so unusual, and how they connect to the long-standing arginine paradox: the biochemical mismatch between how much arginine the body already has and how much it still seems to respond to.
The goal: reveal how one seemingly ordinary amino acid can influence two entirely different biological domains (vascular regulation and protein-folding dynamics) and clarify what is supported in humans, what remains strictly preclinical, and how diet or supplementation can realistically support the pathways where arginine does matter.
00:00 Introduction to Unexpected Research Findings
00:49 The Multifaceted Role of L-Arginine
02:09 The Arginine Paradox and Protein Misfolding
03:25 New Research on Arginine and Amyloid Beta
07:05 Practical Applications and Dietary Recommendations
09:23 Conclusion and Final Thoughts
PMID: 28179487
PMID: 10759111
PMID: 35498050