Lithium appears to contribute to cognitive preservation during aging and a new study looks at what happens to the brain when lithium is deficient, possibly leading to Alzheimer's disease. Better still, it looks like increasing the brain's lithium levels may actually reverse the effects. Lithium orotate is getting a glow-up and we're excited for it!

Also, the "magic pill" may finally be real. Wegovy, one of the popular new GLP-1 weight-loss medications is now available as a daily oral prescription! How does it differ from injections and how is dosing affected? Is it cheaper than the shots?

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Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:29 - Show Intro
01:38 - Study: Alzheimer's and Lithium Deficiency
02:52 - What is Lithium?
04:26 - What was studied?
06:47 - Details about the animal study
08:55 - How is lithium protecting the brain?
12:22 - Lithium in drinking water
13:28 - Takeaways
16:21 - Wegovy Pill
17:31 - Details of the Wegovy Pill
19:45 - Do you need to titrate up?
20:36 - If it's working, do you need to take more?
22:49 - What's the difference between the pill and injectable?
23:59 - Differences in cost
25:13 - Other points
27:43 - Dietary suggestions while on Wegovy
29:54 - Show outro

SHOW NOTES:
1) Lithium and Alzheimer's (Nature) - https://tinyurl.com/aywhpx2h
2) Lithium deficiency and onset of Alzheimers (NIH) - https://tinyurl.com/y2dxvmdf
3) New GLP-1 Pill Compared to Shot (Web MD) - https://tinyurl.com/mt2mvtpv
4) Wegovy Pill in High Demand (NBC News) - https://tinyurl.com/ktb84h54
5) Wegovy pill now available across America (PR Newswire) - https://tinyurl.com/2t6uda9w

DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

At the top of the year, U.S. Department of Health and Human Services Secretary Robert F. Kennedy, Jr. and U.S. Department of Agriculture Secretary Brooke Rollins released the Dietary Guidelines for Americans, 2025–2030, the most significant reset of federal nutrition policy in decades. Emphasizing "real food," the food pyramid we grew up with has essentially been turned upside down. Dante DiMatteo (PharmD) breaks down the changes: What's good, what's bad and what families should take away from this messy government food fight.

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PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://tinyurl.com/GHShowSpotify
Rumble - https://rumble.com/user/GenerationHealth
YouTube - https://tinyurl.com/57hxe6aj
YouTube Clips - https://tinyurl.com/wzk69tbk

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:26 - Show Intro
01:15 - New dietary guidelines
02:41 - What does this update affect?
05:18 - Why is this a "hostile takeover?"
12:12 - Specifics of the new guidelines
12:23 - Changes to Protein
17:07 - Changes to Fat
20:57 - The paradox that's occurring
23:32 - What the guideline authors are focused on
28:29 - Biomarker-dependent decision making
35:48 - Carbohydrate/Insulin Model
41:10 - International Reaction to these changes
42:19 - Blue zones
44:30 - Takeaways
45:35 - Show Outro

SHOW NOTES:
1) Official Gov't Site - https://realfood.gov/
2) The Scientific Foundation for the Dietary Guidelines (CDN) - https://tinyurl.com/586crtx3
3) Anabolic Resistance of Muscle Protein Turnover (NIH) - https://tinyurl.com/mvxp9xy7
4) Moderating "the great debate" (NIH) - https://tinyurl.com/4dhtadtb
5) Carbohydrate-insulin model (Royal Society) - https://tinyurl.com/mwa6m7cf
6) Historic Reset of U.S. Nutrition Policy (USDA) - https://tinyurl.com/64wxzt8k

DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

VO2 Max is having a moment. It seems every fitness influencer and longevity specialist has decided to focus on it as the key metric for determining your health. Is it important? Yes. But making that the key indicator of fitness is a trap.

Then, Dante fields a listener question: What do you do when red wine turns your face, well...bright red. How can you enjoy a glass while avoiding that awful face flush and the terrible feeling that comes along with it?

We love questions! Comment below or email us: questions@askjoedimatteo.com

ALL PRODUCTS: https://www.AskJoeDimatteo.com

CONNECT:
Products - https://askjoedimatteo.com/youtube
Questions - questions@askjoedimatteo.com
Facebook - https://facebook.com/askjoedimatteo
Instagram - https://tinyurl.com/5n6kfwhs

PODCAST:
Apple Podcasts - https://tinyurl.com/GHShowApple
Google Podcasts - https://tinyurl.com/GHShowYTM
Spotify - https://tinyurl.com/GHShowSpotify
Rumble - https://rumble.com/user/GenerationHealth
YouTube - https://tinyurl.com/57hxe6aj
YouTube Clips - https://tinyurl.com/wzk69tbk

Generation Health is a podcast discussing cutting edge research and time tested best practices to help you live better, longer. Joey DiMatteo (PharmD, CCN), & Dante DiMatteo (PharmD) are the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating their extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, they love sharing their wisdom with anyone looking to improve their life!

CHAPTERS:
00:23 - Show Intro
01:22 - VO2 Max
03:52 - What is VO2 Max?
05:51 - Who is Steve Magnus?
09:56 - What does VO2 Max tell you?
10:46 - What should you look at instead of VO2 max?
11:39 - Running economy
13:10 - Lactate Threshold
16:00 - Does VO2 max really matter?
18:49 - Is Zone 2 cardio related to VO2 max?
25:33 - Viewer Question: Red Wine Flush
26:04 - Why does this happen?
27:19 - What are the chemical issues with alcohol?
32:47 - Is there a "trick" with red wine to avoid flush?
34:51 - What to do with the data
40:29 - Show Outro

SHOW NOTES:
1) VO2 Max & metabolic health (Study) - https://tinyurl.com/bdh2jh6u

DISCLAIMER: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Listeners should NOT disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.