Thank you to AbbVie for their support of this Medication Review Video Module.

In this medication review, Melissa Ferrari, PA, and Jennifer Hamilton, MSPAS, PA-C, provide a comprehensive overview of the INSPIRE and COMMAND clinical trials evaluating risankizumab for the treatment of moderately to severely active ulcerative colitis. The discussion reviews the trial design, patient populations, induction and maintenance dosing strategies, clinical and endoscopic endpoints, and the rationale behind the approved dosing regimen. The presenters also explain the significance of the phase 2 dose-ranging study and how the clinical development program informed the FDA-approved treatment approach.

Melissa and Jennifer review key efficacy findings, including clinical remission and endoscopic improvement during both induction and maintenance, with a particular focus on outcomes in advanced therapy-naïve patients. They also discuss practical considerations for selecting between the available maintenance doses, the role of top-down treatment strategies, administration using the on-body injector, and recommendations for patient counseling and liver enzyme monitoring. Safety outcomes are reviewed, reinforcing the established safety profile of risankizumab and providing clinicians with practical guidance for incorporating this IL-23 inhibitor into routine clinical practice.

This educational video is designed for gastroenterology nurse practitioners, physician assistants, gastroenterologists, and other healthcare professionals seeking practical insights into evidence-based treatment of ulcerative colitis. Viewers will gain a deeper understanding of the INSPIRE and COMMAND clinical trial data and how these findings can help guide treatment selection, optimize long-term disease control, and support shared decision-making with patients receiving risankizumab.

For more GI and hepatology education, visit the GHAPP Digital Hub and the GHAPP ACE app.

Thank you to AbbVie for their support on this Medication Review Video Module.

In this medication review, Sharon Dudley-Brown, CRNP, PhD from Johns Hopkins University and Angelina Collins, MSN, ANP-BC, from the University of California San Diego, provide a comprehensive overview of the SEQUENCE trial, a landmark head-to-head study comparing risankizumab and ustekinumab in patients with moderate to severe Crohn’s disease who had previously failed anti-TNF therapy. The discussion explores the trial design, patient population, dosing strategies, primary and secondary endpoints, and the significance of efficacy assessor blinding in an open-label study.

Sharon and Angelina review key findings demonstrating the superiority of risankizumab over ustekinumab across multiple clinical and endoscopic outcomes, including clinical remission, endoscopic response, corticosteroid-free remission, and long-term disease control. They also discuss the importance of objective disease assessment using centrally read endoscopy and the role of steroid tapering in evaluating treatment success. Safety outcomes are examined, highlighting the absence of new safety signals and reinforcing the established safety profile of risankizumab.

This educational video is designed for gastroenterology nurse practitioners, physician assistants, and other healthcare professionals seeking practical insights into evidence-based treatment selection for Crohn’s disease. Viewers will gain a deeper understanding of how the SEQUENCE study may influence treatment positioning of IL-23 therapies in anti-TNF-experienced patients and how emerging long-term extension data continue to support durable clinical remission and endoscopic improvement with risankizumab.

Thank you to Johnson & Johnson for their support on this FAQ Video Module.

In this educational video, Jamie Brogan, APRN, from Northwestern Medicine, reviews the latest QUASAR long-term extension data evaluating the efficacy and safety of guselkumab in adults with moderate to severe ulcerative colitis. This discussion highlights approximately two years of follow-up data, offering healthcare providers valuable insight into the long-term durability of treatment response, clinical remission, endoscopic improvement, and overall safety outcomes associated with guselkumab maintenance therapy.

Jamie walks through the key findings from the ongoing multicenter extension study, including sustained clinical remission rates, corticosteroid-free remission, endoscopic healing, and histologic-endoscopic mucosal improvement through week 92. The video also reviews the maintenance dosing strategies of guselkumab, including 100 mg every 8 weeks and 200 mg every 4 weeks, and discusses how patients who responded during earlier phases of treatment maintained those responses over time. In addition, the presentation covers important long-term safety findings, including rates of serious infections and adverse events observed throughout the study.

This video is designed for gastroenterology APPs, nurse practitioners, physician assistants, gastroenterologists, and healthcare professionals looking to stay current on emerging ulcerative colitis therapies, long-term biologic data, and evolving treatment goals in inflammatory bowel disease (IBD).

For more educational content on ulcerative colitis, Crohn’s disease, gastroenterology, and hepatology, visit the GHAPP Digital Hub and the GHAPP ACE app.