The open-source DIY Sequencer was here.

Update: 454.bio is now dead, but the archives still have it:

https://web.archive.org/web/20250723191639/https://454.bio/

Their GitHub:

https://github.com/454bio

Elements new VITARI:

https://www.elementbiosciences.com/products/preorder-vitari

We have the same thing at home!

- yes, but in worse, cheaper or both

Qitan:

https://pmc.ncbi.nlm.nih.gov/articles/PMC8985760/

https://www.qitantech.com/

The QPinnacle2:

https://www.vcbeathealth.com/article/1821

CycloneSEQ, the MGI-internal clone:

https://en.cyclone-seq.com/nanopTech

https://www.prnewswire.com/news-releases/mgi-launches-new-nanopore-sequencing-products-with-advanced-cycloneseq-technology-302241816.html

https://www.biorxiv.org/content/10.1101/2024.08.19.608720v1

https://rrwick.github.io/2024/12/17/cycloneseq.html

https://gigabytejournal.com/articles/154

https://gigasciencejournal.com/blog/open-cycloneseq-benchmarking-for-complete-bacterial-genomes/

Polyseq:

https://polyseq.com/

Axbio:

https://www.axbio.cn/products/45.html

Geneus-tech:

http://www.geneus-tech.com/proddetail.aspx?id=1

Nice not up-to-date table of specs:

https://github.com/zhangtianyuan666/NanoporeReview2024

ONT to double promethion throughput: https://www.genomeweb.com/sequencing/jpm-oxford-nanopore-shares-plans-double-flow-cell-output-expand-menu-biopharma-market

Artificial Intelligence everywhere, and sometimes its useful.

Correction: apparently the Biostar Handbook is not free anymore :(

AlphaGenome:

https://omicsomics.blogspot.com/2026/02/non-coding-dnas-alpha-moment.html

https://www.alphagenomedocs.com/installation.html

https://www.genomeweb.com/informatics/google-alphagenome-users-scrutinize-ai-models-ability-predict-variant-effects

https://deepmind.google.com/science/alphagenome/

Bioinformatics Forums:

Bioinformatics mistakes on Biostars: https://www.biostars.org/p/7126/

Bioinformatics stackexchange:

https://bioinformatics.stackexchange.com/

Seqanswers:

https://www.seqanswers.com/forum/sequencing-technologies-companies

Vibecoding (current setup, top to bottom):

https://claude.ai/new

https://gemini.google.com/app

https://duck.ai/

If danger is something you enjoy, use this:

https://openclaw.ai/

YOU HAVE BEEN WARNED

Paper about old LLMs that can solve simple, old and solved bioinformatics problems:

https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011511

Youtube has useful bioinformatics courses:

1: https://www.youtube.com/watch?v=3XFpxQF0J74&list=PLWVKUEZ25V95IKyBrxHtRTK_6Ig8Xi9-f

2: https://www.youtube.com/watch?v=LvtPXZHNoCc&list=PLeB-Dlq-v6taAXK6ZCGfqImrNWJzFt3p3