Connect Ovar Coffee: Dr. Alexander Olawaiye

This episode features Dr. Alexander Olawaiye, discussing major advances in ovarian cancer treatment, including the ROSELLA clinical trial.

Key Highlights:
1. Ovarian Cancer Challenges:
- No reliable early screening methods
- Majority diagnosed at advanced stages (Stage III/IV)
- Early detection remains a critical unmet need

2. ROSELLA Trial Breakthrough:
- Focus on platinum-resistant ovarian cancer
- Combines relacorilant (a glucocorticoid receptor antagonist) with nab-paclitaxel
- Demonstrated improved progression-free survival and overall survival
- No biomarker requirement, making it accessible to more patients

3. Mechanism of Action:
- Relacorilant blocks cortisol signaling that promotes chemotherapy resistance
- Enhances effectiveness of chemotherapy

4. Safety & Tolerability:
- No new major toxicities identified
- Side effects consistent with standard chemotherapy

5. Clinical Trial Importance:
- Patients in trials often experience better outcomes
- Participation helps advance future treatments

6. Health Equity & Access:
- Disparities exist in access to care and clinical trials
- Need to improve awareness, access, and inclusion

7. Future Outlook:
- Rapid growth in new treatments over past decade
- Emerging therapies include antibody-drug conjugates
- Continued innovation offers hope for patients

Closing Message:
Stay informed, consider clinical trials, and remain hopeful as new treatments continue to emerge.

1. Future of Gynecologic Oncology and Clinical Trials
2. ADCs (antibody drug conjugates) - what we should know
3. Immunity and Immunotherapy
4. CAR-T Cell Therapy
5. Vaccines
+ MORE!
We discuss on this episode of Connect Ovar Coffee with the Chair of Gynecologic Oncology at Moffitt Cancer Center, Dr. Robert Wenham.
Learn, Share and Be Empowered 💪.
Let's #ConnectOvarCoffee

"You have to feel that you are in the right setting with the right physician who is taking care of YOU personally"

Connect Ovar Coffee ☕️ 2026 is off to a blazing start with an outstanding chat with our Advisory Board Member and Globally renowned Expert Surgeon, Dr. Pedro Ramirez, Chair of OB-GYN at the Houston Methodist.

52 minutes of knowledge, information, compassion and candid guidance - share with anyone who may benefit.

Subscribe. Listen. Learn. Share. Be Empowered! Let's #ConnectOvarCoffee!