This release contains only the music track from Base by Base Episode 403.

Song title: Scars That Tell the Truth
Original Base by Base episode: 403: HRD-GIS Evidence for BRCA1/2 Variant Classification

Article metadata:
Article title: Homologous recombination deficiency-driven genomic instability in ovarian cancer as an indicator of BRCA1 and BRCA2 variant pathogenicity
Journal: The American Journal of Human Genetics
DOI: https://doi.org/10.1016/j.ajhg.2026.05.015
Reference: Schnaiter et al., 2026, The American Journal of Human Genetics 113, 1–8. https://doi.org/10.1016/j.ajhg.2026.05.015

Lyrics:
Verse 1
Under bright screens in the quiet of the night,
We read the damage where the cells lost the fight.
Not every letter screams, not every change is loud,
So we follow the footprints in the broken crowd.

Pre-Chorus
Three little signals, lining up in time,
Loss, shift, and stretch—like a rhythm in a crime.
When the shield goes missing, the pattern starts to show,
A hidden kind of yes, a measured kind of no.

Chorus
These scars don’t lie, they light the way,
A map in the wreckage where the truth can stay.
If the score runs high, it’s a warning sign,
If the score stays low, let the doubt unwind.
We’re not guessing anymore—we’re calling it by design.

Verse 2
Some tumors carry silence where a safeguard should be,
And some look steady, closer to stability.
We weigh what’s likely, we hold it to the scale,
So care can be clearer when the family stories fail.

Bridge
Not perfect, not final, but stronger than before,
A likelihood like footsteps across a lab-room floor.
From haze into evidence, from maybe into proof,
We turn the genome’s weather into shelter, into roof.

Final Chorus
These scars don’t lie, they light the way,
A map in the wreckage where the truth can stay.
If the score runs high, it’s a warning sign,
If the score stays low, let the doubt unwind.
We’re not guessing anymore—we’re calling it by design.

This release contains only the music track from Base by Base Episode 402.

Song title: Outliers in the Light
Original Base by Base episode: 402: When Polygenic Scores Miss: Rare Variants in Misaligned Individuals

Article metadata:
Article title: Individuals who deviate from polygenic expectation are enriched for damaging variants in genes linked to rare disease
Journal: The American Journal of Human Genetics 113, 1–19 (2026)
DOI: 10.1016/j.ajhg.2026.05.013
Reference: Baya N.A., Lassen F.H., Hill B., Venkatesh S.S., Currant H., Lindgren C.M., Palmer D.S., Individuals who deviate from polygenic expectation are enriched for damaging variants in genes linked to rare disease, The American Journal of Human Genetics 113, 1–19 (2026). doi:10.1016/j.ajhg.2026.05.013

Lyrics:
Verse 1
I drew my line in midnight ink,
A score that said I shouldn’t sink,
But life showed up with different math,
A hidden turn, a sideways path.

Pre-Chorus
Some numbers hum, some numbers shout,
But there’s a ghost they leave out,
A single letter out of place,
That changes speed, that shifts the race.

Chorus
I’m an outlier in the light,
Common winds, rare sparks ignite,
When the forecast doesn’t fit the sky,
Look closer—there’s a reason why.

Verse 2
Too short, too tall, bone turning thin,
A quiet break beneath the skin,
A switch that dims, a switch that drives,
Two kinds of code inside our lives.

Bridge
So when the curve won’t hold me tight,
Don’t call it noise, don’t call it slight,
Screen the shadows, name the flame,
Find the gene that bends the game.

Final Chorus
I’m an outlier in the light,
Common winds, rare sparks ignite,
And if the forecast misses true,
The rare can move the common too,
Look closer—there’s a reason why.

This release contains only the music track from Base by Base Episode 401.

Song title: Two Ends of the Same Thread
Original Base by Base episode: 401: LDB1 variants split neurodevelopmental outcomes by location and mechanism

Article metadata:
Article title: De novo variants in LDB1 are linked to distinct neurodevelopmental phenotypes determined by variant location and differing pathomechanisms
Journal: The American Journal of Human Genetics
DOI: 10.1016/j.ajhg.2026.05.012
Reference: Fluri R., Coll-Tané M., Brunet T., et al. De novo variants in LDB1 are linked to distinct neurodevelopmental phenotypes determined by variant location and differing pathomechanisms. The American Journal of Human Genetics. 2026;113:1–15. doi:10.1016/j.ajhg.2026.05.012

Lyrics:
Verse 1
Under white light, the quiet code begins to bend
A single letter slips, and everything depends
Same name on the page, but not the same effect
Two endings of the story in the architect

Pre-Chorus
If it breaks at the front, the partners fall apart
If it shifts at the tail, it rewrites the heart
I’m tracing where it lands, like sparks on a map
Watching shadows gather in the synaptic gap

Chorus
Two ends of the same thread, pulling in the dark
One turns down the volume, one strikes a louder spark
Where you cut the pattern changes what it means
In the brain’s deep waters and the hospital screens
Two ends of the same thread—now we can see
Why one becomes silence, and one won’t let it be

Verse 2
Front-end fractures—can’t link up, can’t hold the line
Not enough to build the scaffold, not enough to shine
Tail-end trouble—won’t let go, won’t play it fair
Clings to the wrong handshake, hangs heavy in the air

Bridge
In tiny wings, the dosage tells the truth again
Rescue or collapse, like weather in a pen
And sometimes it stacks too high, a bright nuclear glare
Clusters in the center like a warning flare

Final Chorus
Two ends of the same thread, pulling in the dark
One is loss of function, one’s a stubborn mark
Where you cut the pattern changes what we see
From ventricles widening to who you’ll grow to be
Two ends of the same thread—hold on, breathe
We name the mechanism, and the future can ease

• (00:00:29) - Two Ends of the Same Breath