The train grinds to a halt somewhere in the Indian Nations, and the bandits get onboard. They take everything on the train worth stealing and gun down a guard to make their escape — just another notch on the belt for Ben Trout and Zack Larsen, two of the most savage killers in the west. US Deputy Marshal Ed Pine follows them to Muskogee. There the trail runs cold, and Ed Pine disappears.

He came west to the Rockies as a young runaway and grew into a legend among the already legendary frontier mountain men. They called him Preacher - a name that would become a monument to all who sought adventure in the savage wilderness of America's untamed west. The only man with the skills to lead a wagon train on the last leg of the rugged Oregon trail, Preacher knows they're headed into trouble. It's hard enough for a hundred greenhorns to survive the wilds of the northwest; being pursued by thieving renegade outlaws and Indians with a thirst for gold makes it damn near impossible.

Smoke Jensen is a young man raised on loss and bitterness, nurtured by a mountain man named Preacher. Now, Smoke Jensen, with a new black horse and an old grudge, slips over the unmarked border into the turbulent Idaho Territory. Ahead is a town called Bury, built on stolen gold, and run by a band of ruthless men who had a hand in the murder of Smoke's brother in the Civil War. Smoke's father died in pursuit of those killers, but urged his son not to waste his life on vengeance....  

It's the dawn of a new century. But on the vast Sugarloaf Ranch not much has changed since legendary gunfighter Smoke Jensen and his wife Sally tamed the land two decades ago. Raising cattle is still a dangerous business - and just as deadly as ever. When Smoke is injured swapping bullets with some cow thieves, Sally puts out a call for help to Matt, Ace, and the rest of the Jensen clan. But time is running out. The bloodthirsty rustlers are ready to strike again - and there are lots more of them. And the Sugarloaf's last defense is Smoke and Sally's next of kin.... 

As the father of a young Crow tribesman, Preacher would like nothing more than to see the long-time natives and newly arrived settlers live together in peace. Then, the killing starts.... As a family man and frontiersman, Jamie Ian MacCallister is more than happy to help the officers at Fort Kearny negotiate a peace treaty with the Crow nation. Until it all goes to hell.... This is not the American dream they were looking for. This is a nightmare. A brutal, blood-drenched frontier war that two heroic men must fight and win - or one struggling nation will never come together.

Crater City, New Mexico, is a bustling mining town brimming with the stench of men hungry to get rich the old fashioned way - by killing the competition. Dennis Conroy is the owner of the biggest saloon in town, and he needs a few good sharpshooters to help protect surveyors laying out a route for a spur line before his rival Hugh Thornton beats him to it. Joe Buckhorn's handy with a gun, so he takes the job. Against his best advice, he'll also take a liking to the boss's daughter. Worse, Buckhorn starts wondering exactly what kind of man he's working for. 

In Tennessee, 17-year-old Breckinridge Wallace knew the laws of nature. When his life was in danger, he showed a fearless instinct to fight back. Killing a thug who was sent to kill him got Breckinridge exiled from his Smoky Mountain home. Brutally wounding an Indian attacker earned him an enemy for life....

Leaving their Pennsylvania home to forge a new life in the untamed Oregon Territory of 1845, the Colter family is ambushed by a kill-crazy gang of cutthroats on the Oregon Trail. Fifteen-year-old Tim Colter manages to escape and hide - only to return and find his parents butchered, his sisters Nancy and Margaret missing, and one last killer waiting for his return. Forced to fight for his life, the young Colter embarks on a perilous journey across a lawless frontier, hoping to save his sisters and salvage the dream they lived for.

In 1848, Dooley Monahan, son of struggling Iowa pioneers, went off to to pick up a new milk cow. Young Dooley never came home. Now, nearly three decades later, Dooley Monahan has become an accidental legend, managing to plant a bullet in the chest of a dangerous outlaw. All Dooley really wants is to claim his reward at a bank in Phoenix and make his way north to a gold strike he read about in a newspaper.

If anyone knows the road to purgatory, it's Red Ryan. As a stagecoach guard, he's faced holdups, ambushes, and all-out attacks from every kill-crazy outlaw, Indian, and prairie rat. But even he's a bit reluctant to take on his next job: riding shotgun with his driver Buttons Muldoon on a stage bound from Fort Concho, Texas, to Fort Bliss.

Descended from a long line of fighters, lovers, and dreamers, the MacCallister clan are legends in their homeland of Scotland. But when Duff MacCallister came to America, it seems he brought the legend - and the war - along with him.... Here in America, life is full of surprises. Duff never expected to hear from his old friend Charles McGregor, his battalion commander from the Black Watch Regiment of Her Majesty's army. Turns out McGregor lives in New Mexico now. And he needs Duff's help.

The Scottish Highlands, 1885. Two men, brandishing knives, attack a young woman outside a pub. Duff MacAllister steps in and saves her - killing one of the assailants. Big mistake. The attacker was the sheriff's son, and now MacAllister is marked for death. His only hope: America. Here, in the sprawling land of dreams, Duff hopes to start a new life with his American cousins. Unfortunately, the sheriff's deputies are tracking him down - with nine of the deadliest cutthroats money can buy. 

After a lifetime of robbing banks and holding up trains, Jimmy "Slash" Braddock and Melvin "Pecos Kid" Baker are ready to call it quits, though not completely by choice. Sold out by their old gang, they have to bust out of jail and pull one last job to finance their early retirement. The target is a rancher's payroll train. Catch is: the train is carrying a Gatling gun and 20 deputy US marshals who know they're coming. Caught and quickly sentenced to hang, their old enemy - the wheelchair-bound, bucket of mean, Marshal L. C. Bledsoe - shows up at the last minute to spare their lives.

When Duff MacCallister sees smoke rising from his neighbor's ranch, he knows something is very wrong. But he isn't prepared for what he finds: smoldering buildings, a rancher and his wife brutally slaughtered, and a 14-year-old survivor who could not save her parents. Now, Duff is going after the killers - and his only companion is the headstrong girl who refuses to be left behind. Duff and his new companion head into the towering Gore Range. Up ahead are two convicted murderers who were about to be hung in Cheyenne and the killers who broke them loose. 

In a town like Chugwater, Wyoming, you know who your friends are, who your enemies are, and who your kill-crazy maniacs are. For Duff MacCallister, the last category belongs to Johnny Taylor and his gang. Duff has wrestled with this polecat before, and knows that his bite is worse than his smell. But when Taylor's gang tries to rob a bank - and Duff manages to shoot one and arrest Taylor's brother - the outraged outlaw raises a stink straight out of hell. First, he begins to randomly slaughter innocent townsfolk one by one.