The East End of London has been devastated by the Blitz and the people are struggling to come to terms with their ravaged city. Rationing bites ever deeper, and and everything that makes life better is in short supply. For the district nurses, the challenges are tougher than ever. Gladys loves her work in the Civil Nursing Reserve, but just when she needs to rely on her sister at home to help out with the chores, she turns into a handful of trouble. Edith is learning to cope with her boyfriend's injuries after Dunkirk but will she have to choose between her love for him and her career?

Alice Lake has arrived in London from Liverpool to start her training as a District Nurse, but her journey has been far from easy. Her parents think that she should settle down and get married, but she has already had her heart broken once and isn’t about to make the same mistake again. Alice and her best friend, Edith, are based in the East End, but before they’ve even got their smart new uniforms on, war breaks out, and Hitler’s bombs are raining down on London.

During World War Two, Churchill declared that 'beauty was duty'. But for the women working at the Yardley cosmetics factory in London's East End, it's friendship and family. Nineteen-year-old Lily Gunn runs the conveyor belt in the factory's Lipstick Room with tight reins, though of all the women working there it's her 16-year-old sister who gives her the most trouble. Especially when Rene's new boyfriend Ronnie gets called up to fight, leaving Rene alone and with a big problem.... 

After the heartbreak of World War Two, newlywed midwife Cathy hoped Liverpool life would offer some joy. But a terrible miscarriage and the escape of her abusive stepfather Jack from prison make happiness hard to find. Meanwhile, Cathy’s beloved granny is ailing. Whilst at the hospital, Cathy sees her midwifery friends, who are planning to open a home for unmarried mothers. After losing a baby of her own, Cathy would love to help, but for now, she must take care of her grandmother.  

It’s 1941, and as the Second World War rages on, girls from all over the country are signing up to the Women’s Land Army. Renowned for their camaraderie and spirit, it is these brave women who step in to take on the gruelling farm work from the men conscripted into the armed forces. When Yorkshire mill girl Una joins the cause, she wonders how she’ll adapt to country life. Luckily she’s quickly befriended by more experienced Land Girls Brenda and Grace. 

The war is almost over - and it's up to the East End Angels to keep the home fires burning! Frankie's fiance, a doctor, is away looking after the troops in Europe - will he return safely home? Winnie has a happy secret - but can she carry on at Station 75 when she's going to have a baby? Bella is intrigued by her new friend, a Polish airman. As the war ends and victory is in sight, what's next for the girls of Station 75?  

1940, Liverpool: Alice Turner and her best friend, Millie Markham, work for the war effort at Rootes munitions factory, making shell caps and Halifax bombers. Alice’s sweetheart, Terry, is home from the front for a brief period of leave. But the honeymoon is soon over. Terry must go back to the dangers of Nazi-occupied France, and the ever-present air raid sirens quickly bring Alice back down to earth. 

Lavender Road boasts a pawnbroker, a pub, two rows of terraced working class homes and, at one end, the big house owned by the local brewer. When war breaks out, the lives and fortunes of the families who live in Lavender Road are changed out of all recognition. For Joyce, it means a struggle to keep food on the family table; for Jen it may mean the end of her dream to become an actress; and for Pam, there is the sickening seesaw of emotions as she fights attraction to her handsome lodger and a growing distance from a husband who is judged not fit to enlist.

Two very different girls from this tight-knit community join up as ARP Wardens to do their bit for the home front. Violet Simms lives with her controlling, widowed mother who runs the local pawn shop. At just 20-years-old, Violet longs for friendship, love and escape. It seems her dreams might come true until tragedy strikes on one of the very worst nights of the Birmingham Blitz. Grace Templeton is the eldest in her family of 10 children. Spirited Grace is determined never to become burdened by child bearing and drudgery like her mother. 

When sixteen-year-old Sally is evacuated to the English south coast, she is terrified by what lies ahead of her. All she knows are the sights and sounds of London's East End – but Sally swallows her tears as they leave the familiar landmarks behind, knowing that she has to be a Grown-Up Girl and play mother to her six-year-old brother Ernie. Playing mother is nothing new for Sally – their real mother Florrie, a good-time girl, hasn't even come to the station to wave them off and Ernie, crippled at an early age by polio, is used to depending on his older sister.

One wild night in the 1930s, midwife Patty Peel is called to attend a birth on the opposite side of Liverpool. She pedals off into the storm and delivers a baby girl in a filthy slum dwelling, just as the mother dies. The drunk and violent father tells Patty to get rid of it so she takes the child away, meaning to deliver it to the nearest orphanage. However, Patty spent her entire childhood in an institution, except for the frequent occasions when she ran away, and cannot bear to hand the baby over. 

Hull, 1940. Widowed Edie Copeland has just arrived on Exchange Street, heavily pregnant and with heavy suitcase in tow. She left York after tragedy struck to make a fresh start, but she's a stranger to this street, and her new landlord doesn't hesitate to remind her of this, widow or not. Luckily, the neighbours are a little more welcoming and Edie is soon made to feel at home by the Maguires and the Scuttles. As air raids sound and the war feels closer than ever, the community has to stick together. But Edie is hiding something, and she doesn't know how much longer her secret is safe.

August 1940: As the Luftwaffe swarm over Liverpool, Shane Quinn decides to move his family back to the safety of Ireland. But his only child, the beautiful Dana, would rather stay and serve her country than flee to a foreign land. Determined to make it on her own, she joins the WAAF with newfound pals Patty and Lucy. There’s plenty of excitement to be had on a RAF station, even a chance or two at love.

Meet The East End Angels, the newest members of Station Seventy-Five's ambulance crew. Strong-willed Winnie loves being part of the crew at Station Seventy-Five, but her parents are less than happy. She has managed to avoid their pleas to join the WRENS so far, but when a tragedy hits too close to home she finds herself wondering if she's cut out for this life after all. Former housemaid Bella was forced to leave the place she loved when she lost it all, and it's taken her a while to find somewhere else to call home. She's finally starting to build a new life, but when the air raids begin, it seems she may have to start over once again.

 1936. Polly's guardian angel has to work overtime when her large family is forced to move from the countryside they love into central Liverpool. Money is desperately short, and with her mother working and her father sick, Polly is easily led astray by the handsome Sunny Andersen. But soon war looms, and Sunny joins the navy to train as a signaller. After the horrors of the May Blitz, Polly, too, decides she wants to help her country and goes into the WRNs. She hears that an old pal, Tad Donoghue from the Dublin slums, is now in the Royal Air Force.