1850. When Opal Sharp finds herself and her younger siblings suddenly orphaned and destitute, she thinks things can get no worse. But soon three of them - including Opal - are struck down with the illness that took their father from them, and her brother Charlie is forced to make an impossible decision. Unable to afford a doctor, he knows the younger children will not survive. So, unbeknownst to Opal, Charlie takes their younger siblings to the workhouse, where he knows they will at least be fed and have a roof over their heads. Opal is heartbroken and struggles to forgive him. 

It’s mid-winter, and in the throes of a fierce blizzard, Elsie Redfern and her husband discover an unknown girl in their hay barn about to give birth. After the young mother dies, Elsie takes the infant in and raises her as her own daughter, her precious storm child. Gina grows into a beautiful little girl, but her safe haven turns out to be anything but. Torn away from her home and family, the child finds herself in a nightmare from which there’s no waking, but despite her misery and bewilderment, Gina’s determined to survive.

East-End London, 1858. In London's twisting streets, it's hard to tell friend from foe. And for Katherine Martin, arriving back in London after years away, the city is crueller than she remembers. Her eyes opened to the plight of London's poor, Kate is determined to do what she can to help, even if it means defying her parents. In secret, she opens a soup kitchen. But there is a world of criminals within London's poorest alleys. Catching the notice of Harry Trader and his gang, Kate is out of her depth. Until she begins to discover that her true enemies might not be who she thought. 

Phoebe Parsons is destitute, disgraced and alone. After her mistress tragically dies, Phoebe is forced back onto the poverty-ridden streets of Manchester by her unforgiving new master. Desperately searching for work as a domestic maid, Phoebe soon discovers her reputation is in ruins. Fearing for her future and haunted by the harshness of her abandonment, Phoebe finds herself living with thieves and drunks in the smog and squalor - until she meets Victor Hayes. 

Emma Price is only a pit bank wench, but she wins the love of Paul Felton, younger brother of the colliery owner. Carver Felton has no intention of seeing his brother throw away his future and rapes Emma, leaving her pregnant. Emma is taken in by butcher Samuel Hollington and his wife and gives birth to her son. Once Carver Felton has achieved his business ambitions, he turns his attentions to finding an heir to the Felton fortune.

It’s Christmas 1880 in London’s East End, and a dying Irish girl leaves her baby in the care of the Sisters of Clemency. The nuns raise little Ettie O’Reilly as their own. But the lives of the nuns and orphans are soon crushed by an unexpected turn of events. Ettie is at her lowest ebb when she is betrayed by the boy who has promised his undying love and loyalty. She is faced with the revelation of a heart-wrenching secret. 

Seventeen-year-old Ruth Hardy works long hours at Grange Paper Works with her younger sister, Bea, and spends her free time caring for their ailing parents. Their meagre income barely covers their needs, so when Bea reveals that she is pregnant out of wedlock, Ruth knows even tougher times are ahead. Ruth's hard work at the mill does not go unnoticed, and it looks as though luck might turn when she's promoted. But when the arrival of Bea's baby girl ends in tragedy, Ruth is left with no choice but to bring up her niece herself. 

Shocked beyond measure at her wrongful imprisonment, Phoebe Pardoe finds it hard to adjust to the harshness of life in the infamous Handsworth Prison. She struggles to maintain her unconquered spirit, little suspecting that her arrest is the work of her jealous Aunt Annie. Phoebe has a guardian angel in the form of Sir William Dartmouth, who eventually engineers her release. But even so, cruelly disinherited, Phoebe must strive to make a living for herself in a man's world.

Banished from her father's home, wheelchair-bound Esther Kerral is horrified when he forces her into an arranged marriage with Morgan Cosmore, the son of a local factory owner. Both fathers hope the union will save their ailing businesses; little do they know that each is as bankrupt as the other. Poor Esther must struggle as best she can not only to survive a loveless marriage, but also to build up a business of her own in a man's world.

Liverpool 1939: Olivia Campbell appears to have the perfect life. However, behind closed doors she lives in constant fear of her abusive father and has no support from her mother. Longing for love and affection, she begins a relationship with Ted, a young lad who works in her father's factory. But her family disapprove of the relationship and forbid them from seeing each other.

Bristol, 1939. School leaver Maisie Miles suspects her father, a small-time crook, has an ulterior motive for insisting she gets a job at the W. D. & H. O. Wills tobacco factory but keeps it to herself. She's befriended by effervescent Phyllis Mason and kind-hearted Bridget Milligan who take pity on her and take Maisie under their wing. But beneath their happy-go-lucky exteriors, they all harbour dreams and worries about what the future holds. 

Accused of killing her brother, Rachel Cade is sent to the workhouse to await trial. There, handsome landowner Jared Lytton comes to her rescue. Despite being vindicated, Rachel is forced to leave the village. She meets the widow Beulah Thomas and her son, William. Working on their farm, she is treated with kindness, and when William asks for her hand in marriage, she agrees. But Rachel cannot forget Jared Lytton, whose path seems destined to cross hers. 

Sunny grew in the mother and baby home on Grove Lane, London. The daughter of a wartime nurse and a Polish pilot, she was abandoned by her mother shortly after her birth and taken in by Nan, the warm and gentle proprietor of the home. Never having known her parents, Sunny has always felt like she doesn't quite fit in, but now, at 16 years old, she is ready to find her place in the world. Heading out to start her first job, she finally feels she has some idea of who she wants to be. As 1950s post-war London is changing at a rapid pace, so is Sunny. 

December 1930. With the Depression biting deeper, it looks like many children in the East End will wake up to nothing on Christmas morning. Widower Robbie Graham earns just enough to put food on the table for his children, Ben and Ruthie. Local cake shop owner Flo Hawkins can't bear the thought of any child having nothing for Christmas. Along with her sister, Honour, she hatches a plan to bring some festive cheer to the community.

The Fitch children are finally safe, after they and their friends were rescued from the grim orphanage, Reed House, by Minnie and Billy Marshall. Their children’s home, Marshall’s, is full of love and laughter and a world away from their terrible ordeal of being sold to Una Reed for five shillings. There are many more children who still need a home, especially in a world where the workhouse is the last option for desperate families and so Minnie makes it her mission to build Marshall’s into a refuge for all the waifs and strays.