When the Todds move into a flat on the Scotland Road, they are strangers to city life: their previous home was a canal barge. Harry gets a job as warehouse manager and his wife, Martha, works in a grocer’s shop whilst Seraphina trains as a teacher, Angela works in Bunney’s Department Store and young Evie starts at regular school. Then circumstances change, and Seraphina takes a job in Lyon’s Corner House. Customers vie for her favours, including an old friend, Toby.... 

Along a blacked-out wartime street a girl is scurrying, a basket on one arm. As sirens begin and bombs crash down, she is filled with panic and, with a heavy heart, abandons her burden in a sheltered doorway, meaning to return later. Even as she disappears in the resulting chaos, the bundle in the basket begins to wail.

Claudia Muldoon and her sister, Jenny, live with their parents and their gran in her house in Blodwen Street. Both parents have good jobs and the family assume they are settled for life, but then Grandpa Muldoon has a seizure and begs his son to return to Ireland. In Ireland the Muldoons flourish and the girls love the freedom of their new life, though as they grow up, disadvantages become clear. Claudia has to find work, so both sisters return to Liverpool and to their old pal Danny, who welcomes them back with delight.

Liverpool, 1934. Hester Lowe agrees to act as governess to spoiled, self-willed little Lonnie Hetherington-Smith when they leave India to live with Lonnie’s elderly aunt in Shaw Street, Liverpool. Hester speedily realises that her new employer dislikes her niece and means to make life uncomfortable for both of them. Things improve a little when they meet the poor but happy Bailey family, who live in a court off Heyworth Street. Hester likes Dick Bailey very much, but her employer does not permit 'followers', and Lonnie and young Ben Bailey are deadly enemies. 

Liverpool 1939: Olivia Campbell appears to have the perfect life. However, behind closed doors she lives in constant fear of her abusive father and has no support from her mother. Longing for love and affection, she begins a relationship with Ted, a young lad who works in her father's factory. But her family disapprove of the relationship and forbid them from seeing each other.

It's 1938, and Cadi is chosen to be Rose Queen in the annual Rose Fete. She is thrilled to be treated like royalty for the day. But deep down she is desperate to leave the Welsh mining community where she grew up. When war is declared, Cadi and her best friend, Poppy, see a chance to escape. Cadi leaves behind her parents and local boy Aled, whom she is meant to marry, for Liverpool.

Lizzie is an orphan living with her aunt Annie, uncle Perce and two boy cousins within a stone's throw of the Leeds and Liverpool Canal. Lizzie loves her aunt but is hated by her uncle. She makes friends with Geoff Gardiner, another orphan, and is teaching him to swim in the Scaldy when Clem Gilligan rescues the pair of them from drowning. Clem works on the canal boat, The Liverpool Rose, with Jake Pridmore and his wife, plying between the great cities of Leeds and Liverpool. Lizzie's situation at home starts to worsen and eventually she is forced to flee. Her first instinct is to make for the canal, but finding Clem is not so easy....

Dana and Caitlin meet on the ferry from Ireland, both in search of new lives in Liverpool, having left their secrets behind in Ireland. But Dana is ambitious, and when the opportunity comes to own their own tearoom she persuades her friend to join her. No one is willing to rent property to a couple of girls, so when Caitlin’s new man-friend says he’ll back them, they are delighted. Soon the tearoom is thriving.

Liverpool, 1917. When Irish seaman Michael Gallagher docks in Liverpool after years of fighting with the British Navy, he never expects to fall in love. But the moment he glimpses Stella Bennett, all thoughts of returning to his homeland vanish. Determined to be together, the young couple defy Stella’s parents’ wishes. But their plans to marry are soon derailed by the arrival of baby Ginny. Her crop of fiery red hair plants a seed of doubt in her father’s mind, and it’s not long before their world begins to fall apart.

Liverpool, 1935. Kathy Kelling is coming home to Daisy Street from her first day at the High School, longing to tell her friend, Jane, all about it. The Kellings' life becomes a struggle when Kathy’s brother, Billy, has a serious accident. He needs constant attention, and Mrs Kelling must take in lodgers so that Kathy’s schooling does not suffer. When war breaks out, Kathy and Jane are forced to grow up fast. Kathy meets the handsome Alec Hewitt, but he is more attracted to blonde, bubbly Jane. But Fate has not yet finished with Kathy Kelling.... 

Imogen, Rita and Debby all missed the original evacuation and now the authorities are finding it difficult to place them. When Auntie and her niece, Jill, who run the Canary and Linnet Public House, offer to take them in, the billeting officer is greatly relieved. The countryside is heaven to the three little townies, especially after they meet Woody and Josh. They find that by climbing to the top of a tree they are able to watch the comings and goings of the young fighter pilots.

When Daisy's family lose their croft on the Connemara coast, her Aunt Jane, housekeeper to Dr. and Mrs Venables, offers to take Daisy back to Liverpool.

Miranda Lovage and her mother have a blazing row when Arabella tells her daughter that she can no longer afford their present lifestyle. Miranda goes to bed angry and upset. When she awakes next morning, however, it is to find that her mother has disappeared. Miranda raises the alarm but everyone is baffled, and when searches fail to discover Arabella's whereabouts, Miranda is forced to live with her Aunt Vi and cousin Beth, who resent her presence and treat her badly.

Addy and Prue Fairweather live with their widowed mother Nell, in a flat above her shop. Addy is plain and always in trouble whereas Prue is as angelic as her looks imply. To make matters worse, Nell makes no secret of her preference for the younger girl, increasing Addy's jealousy. On the other side of the coin, Giles Frobisher and his twin sister, Gillian, live in a crumbling mansion in Devon. The family have lost most of their money in the Depression, so Giles joins the Fleet Air Arm.

Amy Logan’s family are poor but proud. They scrape a living by shrimping for the big Liverpool fish market, which Amy hates. It’s only because her beloved - and strict - mother rules her with a rod of iron that she mucks in. But Isobel Logan dies in childbirth, and Amy and her brothers start to run wild. Matters aren’t helped when her father marries Suzie Keagan from down the street. Until now, Suzie has managed to conceal a dislike for housekeeping, and she forces Amy to slave at chores. Desperate to escape, Amy leaves home to take her first job.