The Clara Conjecture is a new interpretation of historical facts. In 1938 Germany occupied Austria. Professor Lise Meitner, no longer shielded by her Austrian passport from measures against Jews, was fired. An equal of Niels Bohr and Albert Einstein, she had led the world's best theoretical physics institute for nearly 30 years. In Berlin she designed the experiment that would split the uranium atom to produce energy.

Before it could be executed she fled to Sweden. Without the ability to continue her research, impoverished, fearing for her relatives in the Nazi Reich, she became depressed. In the tiny community of women scientists in Stockholm she met a psychoanalyst, the Canadian Dr. Leone McGregor Hellstedt (alter ego "Clara"), who rescued Lise with psychotherapy and money. When her German colleagues performed Lise's experiment, they asked her to explain the result: she did, in terms of Einstein's E=mc², and called the new phenomenon "nuclear fission" in her article for Nature.

Early in 1939 physicists everywhere grasped the menace of nuclear energy. From her former colleagues and students Lise received information about the Nazi atomic bomb program and relayed it to Clara, who then informed Allied spies including William Stephenson ("Intrepid") of British Security Coordination and Ian Fleming of British Naval Intelligence. Informed by this detailed knowledge of Nazi atomic bomb initiatives, the Allies were able to efficiently sabotage facilities, kill key personnel, deny resources, and thus cripple the German program that had begun more than two years before the Manhattan Project.