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Summary

Almost daily, headlines announce newly discovered links between cancers and their genetic causes. Science journalist Jessica Wapner vividly relates the backstory behind those headlines, reconstructing the crucial breakthroughs, explaining the science behind them, and giving due to the dozens of researchers, doctors, and patients whose curiosity and determination restored the promise of a future to the more than 50,000 people diagnosed each year with chronic myeloid leukemia (CML). It is an astonishing tale that will provide victims of other cancers and their loved ones realistic hope that cures may yet be found in their lifetimes.

The Philadelphia Chromosome charts the milestones that led to present-day cancer treatment and tells the inspiring story of the dedicated men and women who, working individually and in concert, have sought to plum the mysteries of the human genome in order to conquer those deadly and most feared diseases called cancer.

©2013 Jessica Wapner (P)2013 HighBridge Company.

Critic reviews

“[Wapner’s] gracefully written history skillfully combines both the science and humanity of this fascinating search for a cure for chronic myeloid leukemia.” ( Publishers Weekly)
“The story of the Philadelphia chromosome is truly the story of modern cancer biology. . . . Jessica Wapner stitches the whole story together with tenacity, diligence (and humor). This is a wonderful, readable, and highly informative book.” (Siddhartha Mukherjee, Pulitzer Prize-winning author of The Emperor of all Maladies)

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  • sarah
  • LONDON, United Kingdom
  • 24-01-16

dull as ditch water

i found this incredibly dull and tedious - I wanted a book that would have explained something interesting about genetics, rather than give a detailed history of what the researchers had for tea each day. The informative elements about genetics could have been summarised in a single page, as could the meaningful history of the research process - the remainder is just meaningless platitudes... Maybe I'm being too harsh, but I really felt it as a complete waste of my time to have listened to this.

2 of 2 people found this review helpful

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  • l
  • 22-09-14

great read

What did you like most about The Philadelphia Chromosome?

it is well written. I know someone who had a bone marrow transfer in the 80s in order to cure her leukemia. She was lucky. she is alive to this day I am also reading "the emperor of all maladies - a biography of cancer" this is the more updated version and the future. cure disease by understanding how it works

1 of 1 people found this review helpful

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excellence in a book

just great to learn molecular biology of cancer. not for those without a good interest in science

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  • Ronda
  • 17-03-16

Great topic for those in medicine

This book details the research and development and treatment for CML patients with the Philadelphia Chromosome defect. I work with cancer patients so I found the book extremely interesting--not overly technical for the lay person, but technical enough to keep me interested and listening with anticipation.

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  • Michael D. Stone
  • 27-06-13

GREAT story.

If you could sum up The Philadelphia Chromosome in three words, what would they be?

Encouraging wonderful story

Who was your favorite character and why?

Dr Brian Druker.... a TRUE modern day HERO!

Have you listened to any of Heather Henderson’s other performances before? How does this one compare?

No

Was there a moment in the book that particularly moved you?

anything that referred to Dr Drukers drive to see this all the way through

Any additional comments?

A REALLY good and important book. Inspirational. Criticism? a tad too repetetive.

2 of 3 people found this review helpful