The London summer of 1854 is drawing to a close when a deadly outbreak of cholera grips the city. Florence Nightingale is back on the scene marshaling her nurses to help treat countless suffering patients at Middlesex Hospital as the disease tears through the Soho slums. But beyond the dangers of the disease, something even more evil is seeping through the ailing streets of London. It begins with an attack on the carriage of Florence's friend, Elizabeth Herbert, wife of Secretary at War Sidney Herbert. Elizabeth survives, but her coachman does not.

One of Victorian London's most respected undertakers, Violet Harper has the new duty of accompanying coffins from various undertakers on the London Necropolis Railway for respectful funerals and burials in Surrey. But on her fateful first trip, the mournful silence of the train is shattered by the shrill ringing of a coffin bell - a device that prevents a person from being buried alive.

The real monsters are men. London 1888, and Jack the Ripper is terrorizing the people of the city. Evelyn, a young woman disfigured by her dangerous work in a matchstick factory, with nowhere to go, does not know what to make of her new position as a maid to the Elephant Man in London Hospital. Evelyn wanted to be locked away from the world like he is, shut away from the filth and dangers of the streets. But in Joseph Merrick, the Elephant Man, she finds a gentle kindred who does not recoil from her and who understands her pain.

The year is 1896, and college professor Concordia Wells has her hands full: teaching classes, acting as live-in chaperone to a cottage of lively female students, and directing the student play, Macbeth. But mystery and murder are not confined to the stage, especially when the death of Concordia's sister, Mary, appears to be foul play. To make matters worse, the women's college is plagued by malicious pranks, arson, money troubles, and the apparent suicide of a college official.

Major Robert Kurland has returned to the quiet vistas of Kurland St. Mary to recuperate from the horrors of Waterloo. However injured his body may be, his mind is as active as ever. Too active, perhaps. When he glimpses a shadowy figure from his bedroom window struggling with a heavy load, the tranquil façade of the village begins to loom sinister....

After a past family tragedy for which she holds herself to blame, Dr. Genevieve Summerford wants nothing more than to succeed in her new career as a psychiatrist, and win back the respect of her family and peers. That goal is thrown into jeopardy, however, when one of her patients is arrested for murder - a murder Genevieve fears she may have unwittingly provoked. Desperate to prove to herself and the authorities that her patient is innocent, she is forced to enlist the aid of an influential Tammany captain.

Lt. Joe Gunther of the Brattleboro, Vermont, police force has a serious problem: in a community where a decade could pass without a single murder, the body count is suddenly mounting. Innocent citizens are being killed - and others set up - seemingly orchestrated by a mysterious ski-masked man. Signs suggest that a three-year-old murder trial might lie at the heart of things, but it's a case that many in the department would prefer remained closed. A man of quiet integrity, Lt. Gunther knows that he must pursue the case to its conclusion, wherever it leads.

Katie LeClair has finally settled down as the new doctor in Baxter, Michigan. After years of moving, schooling, and training, she wants nothing more than to find a place she can call home, and a small town outside of Ann Arbor seems perfect. Katie quickly gets to work in building a life for herself in Baxter, and beyond reviving her love life, she also finds a pair of business partners in a team of father and son family practitioners. But that idyllic dream is immediately shattered when one of her patients is found dead.

Leaving his home and shelving his career ambitions aren't the only sacrifices Ben faces. His unfaithful wife, Penny, is accompanying him to Cornwall in a last-ditch effort to save their marriage. But moments after their arrival, Penny is run down in the street, and Ben is almost fatally injured. And while the villagers assume Penny's death to be an accident, Ben quickly deduces it was murder.

Accepting employment as a governess after hard times hit her family, medieval scholar Rosalind Hawkins is surprised when she learns that her mysterious employer has no children and only wants her to read to him through a speaking tube.

Deep in the muddy fields of the Lincolnshire Fens, a teenage girl is found wandering, delirious, claiming to have been drugged at a party. Metres away, the drowned body of another girl is found on an isolated beach. And all this on a small stretch of land where, nearly 10 years ago, the shocking disappearance of a young girl remains an open case.

Homicide detective Frost Easton doesn't like coincidences. When a series of bizarre deaths rock San Francisco - as seemingly random women suffer violent psychotic breaks - Frost looks for a connection that leads him to psychiatrist Francesca Stein. Frankie's controversial therapy helps people erase their most terrifying memories...and all the victims were her patients.

The year is 1883, and in New York City it's a time of dizzying splendor, crushing poverty, and tremendous change. With the gravity-defying Brooklyn Bridge nearly complete and New York in the grips of antivice crusader Anthony Comstock, Anna Savard and her cousin, Sophie - both graduates of the Woman's Medical School - treat the city's most vulnerable, even if doing so may put everything they've strived for in jeopardy.

In Cambridge a child has been hideously murdered and other children have disappeared. The Jews, made scapegoats by the all-powerful Christian clergy, have been forced to retreat into the castle to avoid slaughter by angry townspeople. Henry, King of England, is displeased. The Jews provide a large part of his revenue and therefore the real killer must be found, and quickly.

On his first week on the job, Garda Cormac Reilly responds to a call at a decrepit country house to find two silent, neglected children waiting for him - 15-year-old Maude and five-year-old Jack. Their mother lies dead upstairs. Twenty years later, Cormac has left his high-flying career as a detective in Dublin and returned to Galway. As he struggles to navigate the politics of a new police station, Maude and Jack return to haunt him. What ties a recent suicide to the woman's death so long ago? And who among his new colleagues can Cormac really trust?