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Lifespan cover art

Lifespan

By: Dr David A. Sinclair,Matthew D. LaPlante
Narrated by: Dr David A. Sinclair
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Summary

In this paradigm-shifting book from acclaimed Harvard Medical School doctor and one of TIME magazine’s 100 most influential people on earth, Dr. David Sinclair reveals that everything we think we know about ageing is wrong, and shares the surprising, scientifically-proven methods that can help listeners live younger, longer.

For decades, the medical community has looked to a variety of reasons for why we age, and the consensus is that no one dies of old age; they die of age-related diseases. That's because ageing is not a disease – it is inevitable.

But what if everything you think you know about ageing is wrong?

What if ageing is a disease? And that disease is curable.

In THE EVOLUTION OF AGEING, Dr. David Sinclair, one of the world’s foremost authorities on genetics and ageing, argues just that. He has dedicated his life’s work to chasing more than a longer lifespan – he wants to enable people to live longer, healthier, and disease-free well into our hundreds. In this book, he reveals a bold new theory of ageing, one that pinpoints a root cause of ageing that lies in an ancient genetic survival circuit. This genetic trick – a circuit designed to halt reproduction in order to repair damage to the genome –has enabled earth’s early microcosms to survive and evolve into more advanced organisms. But this same survival circuit is the reason we age: as genetic damage accumulates over our lifespans from UV rays, environmental toxins, and unhealthy diets, our genome is overwhelmed, causing gray hair, wrinkles, achy joints, heart issues, dementia, and, ultimately, death.

But genes aren’t our destiny; we have more control over them than we’ve been taught to believe. We can’t change our DNA, but we can harness the power of the epigenome to realise the true potential of our genes. Drawing on his cutting-edge findings at the forefront of medical research, Dr. Sinclair will provide a scientifically-proven roadmap to reverse the genetic clock by activating our vitality genes, so we can live younger longer. Listeners will discover how a few simple lifestyle changes – like intermittent fasting, avoiding too much animal protein, limiting sugar, avoiding x-rays, exercising with the right intensity, and even trying cold therapy – can activate our vitality genes. Dr. Sinclair ends the book with a look to the near future, exploring what the world might look like – and what will need to change – when we are all living well to 120 or more.

Dr. Sinclair takes what we have long accepted as the limits of human potential and mortality and turns them into choices. LIFESPAN is destined to be the biggest book on genes, biology, and longevity of this decade.

PLEASE NOTE: When you purchase this title, the accompanying PDF will be available in your Audible Library along with the audio.

©2019 Dr David A. Sinclair (P)2019 HarperCollins Publishers Limited

Critic reviews

‘If you ever wondered how we age, if we can slow or even reverse aging, and if we can live a healthy 100 plus years, then David Sinclair’s new book Lifespan, which reads like a detective novel, will guide you through the science and the practical strategies to make your health span equal your lifespan, and make your lifespan long and vibrant.’ – Mark Hyman, MD Director, Cleveland Clinic Center for Functional Medicine and #1 New York Times bestselling author

‘This is the most visionary book about aging I have ever read. Seize the day–and seize this book!’ – Dean Ornish, MD, founder & president, Preventive Medicine Research Institute, and New York Times bestselling author of UnDo It!

‘In this insightful and provocative book that asks questions about how we age, and whether humans can overcome decay and degeneration, Sinclair grapples with some of the most fundamental questions around the science of aging. The result is an elegant and exciting book that deserves to be read broadly and deeply.’ – Siddhartha Mukherjee, Pulitzer Prize–winning and #1 New York Times bestselling author

What listeners say about Lifespan

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  • Overall
    3 out of 5 stars
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    3 out of 5 stars

Good science bundled with annoying social justice

The book starts well, with a bit of biographical information that informs us why he is trying to help people live longer, and goes into some excellent science on the topic. I was fascinated by the history of his research into his own theory of ageing, how his and other theories have played out over time, and the current state of play. Unfortunately the final section is pure social theory, unsupported left wing talking points and climate alarmism presented as fact. Honestly when he makes statements about how he is proud he is of his son, who wants to become a social justice activist and politician, and that the world needs people like him to break the "global patriarchy" - then goes on to wonder at why his son is depressed and doesnt value his work to increase lifespan... well.... lets just say I'm suddenly re-evaluating everything else Sinclair says. I'll take his expertise on the science of ageing, but I think I'll pass on the rest. Damn shame, if he had spent the time focusing on the science, rather than pushing a social agenda or placing arguments down only for a specific demographic, the book could have been great.

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83 people found this helpful

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    2 out of 5 stars
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    2 out of 5 stars

only two takeaways and allot of story telling

so to save time, restricting eating or intermittent fasting and take mnm and resveratrol. done your most welcome. book started well with an impacting intro but in the end especially towards the end of the book I had to speed it up to get to anything of note and at the end it was mostly about the writers visions and sales to government to give more funding.

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69 people found this helpful

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    1 out of 5 stars
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Not especially to the point

I expected a learning resource from this. Instead, this is filled with little anecdotes about the authors life as well as countless name drops. I don't especially care for someone's rather boring academic life story. The entire book could have spanned a single chapter, or maybe he should have stuck with writing journal entries.

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19 people found this helpful

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    2 out of 5 stars
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    1 out of 5 stars

Some interesting information

I read the book from cover to cover. I think the information he provides needs to be taken with a grain of salt, not the one about the possibility of expanding or lifespan funny enough. I actually liked DR David Sinclair before reading the book but at a certain point I felt a major brainwash coming and I was right, when he started talking about how safe GMO’s are and how amazing Bill Gates is he completely lost me. I understand to live naturally is hard or even impossible, but we all know the doggy things in studies published about GMO and withdrawn after heavy lobbying from GMO companies, or do we?
Funny enough even the University he is representing has fallen in my eyes, it makes sense now what sort of games they are playing and as always... money talks!

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16 people found this helpful

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    2 out of 5 stars
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    1 out of 5 stars

drawn out into a "book" that should be a podcast

This book was like putting needles under your fingernails. So painfully elongated and drawn out narrated with the most monotonous voice ever imagined.
Honestly, the core information that the author had could have been easily compressed into a podcast instead of going on a tangent to talk about unrelated themes.
I had high expectations for this book and sadly it was not worth my time at all.

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14 people found this helpful

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    5 out of 5 stars
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This book will change your life and the world.

A lot of people are going to talk about the book. Get in ahead of the curve and read/listen to it now.

In David's own words this book will be out of date in 2/3 years because the science of longevity is evolvibg all the time. Which is a good thing. And I hope is get some revisions in a couple or years.

David has also taken the time to speak the book himself which is very time consuming and he should also receive merit for that too.

This book is amazing and definitely worth a listen.

I really hope a lot of people from governments and health organisations get to read/listen to it and talk about it. If this book doesn't change the world David Sinclair definitely will. It's science fiction coming true again just like self driving cars and free energy is also coming true.

I heard about the book from Dave Asprey and Dr Joe Mercola who's books are also worth a read/listen.

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8 people found this helpful

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    4 out of 5 stars
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    3 out of 5 stars

Heady aspirations.

Life extension research and it's implications.
Personally I enjoyed the science parts at the beginning of the book. The implications of longer lives felt like it was turning into a sermon and went on too long for me.
On the whole exciting science though and Dr Sinclair definitely has the enthusiastic voice & experience to rally the charge.

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7 people found this helpful

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    5 out of 5 stars
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    5 out of 5 stars

Mind blowing

I loved it - a complete paradigm shit that may add decades of healthy life to your lifespan.

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6 people found this helpful

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Fantastic

great book, if you are interested in longevity and the science behind it, read this!

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5 people found this helpful

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Informative

The information given on ageing and disease is invaluable. The stories were a bonus.

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5 people found this helpful