Call the Midwife meets Dr Barnardo's in this gritty drama that will appeal to fans of Katie Flynn. St Saviour's will never turn a homeless child away.... When there is nowhere else to turn, St Saviour's will give them hope.... It's 1948, and London's East End is still a bombed-out landscape. Sister Beatrice, who runs the St Saviour's Children's Home, knows that life is still a precarious existence for many children, and it seems that there is no end to the constant stream of waifs and strays who appear at their door....

Eliza was left as a small baby at the workhouse in Whitechapel, wrapped in her mother’s shawl, which is all she has of the mother she never knew. At 11 years old, she has survived sickness, near starvation and harsh beatings. Master Simpkins and his cruel daughter rule the workhouse with a rod of iron, but when Romany boy Joe arrives at the workhouse, his spirit and courage give Eliza hope. When she is sold into service, Eliza is relieved to be out of the workhouse and hopes her fortunes are changing for the better, but cruelty and unkindness are everywhere....

Jonny has had a bad start in life and has been taken in by a neighbour after the death of his mother. Small for his age, he is prey to a band of local thugs, so he joins the boxing club and learns to defend himself. When a violent altercation ends in tragedy, Jonny runs away and meets a homeless young girl called Cassie, who has been living in an abandoned house - touched by her predicament, Jonny vows to look after her, whatever that takes. Cassie desperately needs love and a safe place to call home, and there are kind hearts who want to help. 

Christmas Eve, 1909. When 11-year-old Lily Larkin is left to fend for herself in an East London workhouse after her dying mother is taken to an infirmary, her future looks bleak. Once she is separated from her twin brother, Davy, her childhood hopes seem to shatter. But Lily's fierce spirit - along with her beloved new friends - help her to endure the miserable drudgery of life at South Grove Workhouse and its cruel supervisor, Miss Fox.

1850. When Opal Sharp finds herself and her younger siblings suddenly orphaned and destitute, she thinks things can get no worse. But soon three of them - including Opal - are struck down with the illness that took their father from them, and her brother Charlie is forced to make an impossible decision. Unable to afford a doctor, he knows the younger children will not survive. So, unbeknownst to Opal, Charlie takes their younger siblings to the workhouse, where he knows they will at least be fed and have a roof over their heads. Opal is heartbroken and struggles to forgive him. 

Bristol, 1939. School leaver Maisie Miles suspects her father, a small-time crook, has an ulterior motive for insisting she gets a job at the W. D. & H. O. Wills tobacco factory but keeps it to herself. She's befriended by effervescent Phyllis Mason and kind-hearted Bridget Milligan who take pity on her and take Maisie under their wing. But beneath their happy-go-lucky exteriors, they all harbour dreams and worries about what the future holds. 

Having suffered much cruelty at the hands of her father, Isabel Kenton is shocked to hear after his death that he was not her real father. Isabel inherits their house while her twin brother, Mark, is left the family steel works. But when World War I breaks out, Mark joins the RAF, and Isabel must take responsibility for the management of the business. Struggling to keep the business alive, she must also discover who she really is.

East-End London, 1858. In London's twisting streets, it's hard to tell friend from foe. And for Katherine Martin, arriving back in London after years away, the city is crueller than she remembers. Her eyes opened to the plight of London's poor, Kate is determined to do what she can to help, even if it means defying her parents. In secret, she opens a soup kitchen. But there is a world of criminals within London's poorest alleys. Catching the notice of Harry Trader and his gang, Kate is out of her depth. Until she begins to discover that her true enemies might not be who she thought. 

It’s mid-winter, and in the throes of a fierce blizzard, Elsie Redfern and her husband discover an unknown girl in their hay barn about to give birth. After the young mother dies, Elsie takes the infant in and raises her as her own daughter, her precious storm child. Gina grows into a beautiful little girl, but her safe haven turns out to be anything but. Torn away from her home and family, the child finds herself in a nightmare from which there’s no waking, but despite her misery and bewilderment, Gina’s determined to survive.

Carrie Preston is used to hard work - oldest of 10, with an incompetent mother and a drunken father, she struggles to find food for her siblings. But nothing could have prepared her for the day fate deals her family the cruellest of hands, rendering them more desperate than ever. In a harsh world, small acts of kindness can bring great hope - Eli Beckett's offer of a job at the Dragon pub promises a better future for Carrie, especially as Eli's uncle has offered his nephew some spare land to build a music room.

1850: Beatrix Fawcett is just 18 when her father tells her she is to marry a stranger. Hesitant, but with little choice, she agrees to the match - with hope for a good husband in Charles and the surprising delight of a lovely Yorkshire house in which they are to live. As Beatrix sets to making the house a home, she falls in love with it and the countryside nearby. But she does not fall in love with her husband.... It's clear Charles has chosen her simply to meet the requirements of his inheritance and has little interest in his young wife.

Emmy Carter's mother is a prostitute - and her life has made Emmy determined to avoid the same fate. But Emmy is beautiful, so attracts unwanted attention; her mother's protector has his eye on her, as does evil Marcus Armistead, her employer's nephew. Marcus is excited by Emmy's virginity and has her kidnapped, but Emmy hits him over the head and escapes. Marcus, further enraged, kills her mother and becomes even more determined to rape Emmy, but the combined efforts of the local parson and Emmy's young suitor manage to keep her safe from harm. 

Accused of killing her brother, Rachel Cade is sent to the workhouse to await trial. There, handsome landowner Jared Lytton comes to her rescue. Despite being vindicated, Rachel is forced to leave the village. She meets the widow Beulah Thomas and her son, William. Working on their farm, she is treated with kindness, and when William asks for her hand in marriage, she agrees. But Rachel cannot forget Jared Lytton, whose path seems destined to cross hers. 

England, 1943: Home is no longer safe for eight-year-old twins Molly and Jacob. Night after night, wailing bombs and screeching planes skim the rooftops overhead. They cradle each other, shivering in terror, not knowing if they'll live to see dawn. Their mother, Martha, has no choice but to evacuate them to the safety of the countryside. At the train station, Martha bites back tears as she says good-bye to her precious children. Knowing she might never see them again, she gives Jacob a letter, pressing the envelope into his hands and telling him to only read it if they are in danger.

Holding the letter in trembling hands, Daisy’s future crumbled before her – the words engraved on her heart forever. The village of Little Creek, the long winter of 1867. The first flakes of snow are falling when Daisy Marshall, secretly engaged to her master's son, finds herself jilted at the altar. Heartbroken, Daisy flees to the small village of Little Creek, nestled on the coast of Essex. There she is warmly welcomed – but the village is poverty-stricken, suffering under a cruel lord of the manor. And when cholera hits, the villagers are truly in dire straits.