In this in-person episode of Ketamine Connections, I sit down with Dr. James Leathem — anesthesiologist turned psychedelic pioneer — to explore what transformational medicine actually means.

We talk about rejection as redirection, trusting the process, and what it takes to build something meaningful — in medicine and in life. Dr. James shares his journey from failing into medical school twice to building a comprehensive ketamine clinic model rooted in safety, preparation, and integration.

We break down what makes ketamine therapy effective for depression, PTSD, and anxiety — and what most people misunderstand. Neuroplasticity is neutral. Ketamine may open the door, but what you do afterward determines whether you reinforce old patterns or build new ones. It’s a tool, not a cure.

We also explore safety as the foundation of healing, why ego is attachment to familiar suffering (not arrogance), and how anxiety can be reframed as “future awareness.” This episode ends on a cliffhanger as we begin defining ego — a conversation that continues in Part Two (come back next week!), where we dive deeper into clinical protocols and methodology.

Dr. James has also spoken about transformational medicine and the future of ketamine care.

If you’re considering ketamine therapy, or want to understand how to maximize its impact through preparation and integration, this episode is for you.

This episode is educational and not medical advice. Please consult your healthcare provider before making changes to your treatment plan.

🔗 Resources Mentioned

• Advanced Wellness & Pain – Scottsdale & Gilbert, Arizona
• Joe Dispenza (Neuroplasticity reference)
• Inside Out 2 (Film)
• Ketamine Preparation Protocol