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Join Heather Binning who hosts this week’s special guests Louise Irvine, co-chair of the Clinical Advisory Network on Sex and Gender and Terry Patterson from Thoughtful Therapists.

Louise and Terry explain why there are enormous concerns from sector experts regarding the ethical grounds and outcomes competence of the UK puberty blockers trial called ‘Pathway’, a medical trial which will involve around 220 children under the age of 16.

We hear explanation of the scrutiny stages that UK clinical trials must successfully pass through in order to be granted approval, as well as questioning how this safety net has failed

Useful Links ...

Clinical Advisory Network on Sex and Gender: https://can-sg.org

Open Letter from CAN-SG: https://can-sg.org/2025/12/18/open-letter-to-wes-streeting-on-the-pathways-puberty-blockers-trial/

Thoughtful Therapists: https://www.thoughtfultherapists.org

National Institute for Health and Care Research: https://fundingawards.nihr.ac.uk/award/NIHR167530

Health Research Authority: https://www.hra.nhs.uk/planning-and-improving-research/application-summaries/research-summaries/pathways-trial/

Medicines & Healthcare products Regulatory Agency: https://www.gov.uk/government/organisations/medicines-and-healthcare-products-regulatory-agency

Commission on Human Medicines: https://www.gov.uk/government/organisations/commission-on-human-medicines

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