Liverpool 1939: Olivia Campbell appears to have the perfect life. However, behind closed doors she lives in constant fear of her abusive father and has no support from her mother. Longing for love and affection, she begins a relationship with Ted, a young lad who works in her father's factory. But her family disapprove of the relationship and forbid them from seeing each other.

It is 1937, and Alice, Edith and Marg continue to face hardships every day, growing up on one of the poorest streets in Blackpool. Penniless, their friendship has helped them survive this far, but it'll take more than that to see them through the dark days ahead. Alice is coping with a violent father. Marg is left reeling after a dark secret about her birth comes to light and threatens to destroy the life she knows, and Edith is fighting to protect her alcoholic mother from the shame of their neighbours and keep her brother on the straight and narrow. 

In 1820, Salem Street is sparkling and new: eight small terraced houses built by a Lancashire mill owner for his best workers. Annie Gibson's family is one of the first to move in - a step up in the world for them. But when her mother dies, Annie's happy childhood ends and she is left to bring up her brother and sister. Red-haired, intelligent and startlingly pretty, Annie soon finds herself banished from home by a jealous stepmother. She finds work in the local doctor's household, where she learns about the fascinating world outside Salem Street.

Miranda Lovage and her mother have a blazing row when Arabella tells her daughter that she can no longer afford their present lifestyle. Miranda goes to bed angry and upset. When she awakes next morning, however, it is to find that her mother has disappeared. Miranda raises the alarm but everyone is baffled, and when searches fail to discover Arabella's whereabouts, Miranda is forced to live with her Aunt Vi and cousin Beth, who resent her presence and treat her badly.

Marianne seems to have everything. She is married to a handsome Naval officer, Neil Sheridan. They have a daughter, Libby, and a beautiful home near Prince's Park in Liverpool. When war comes, Marianne takes war work and moves in with her mother, Mrs Wainwright, and younger sister. Neil disapproves because the Wainwrights live close to the docks, which are bound to be a bombing target, but Marianne is firm.

Hetty Gilbert is a canal child with no permanent address, so when she needs to join the library, she cannot do so. Miss Preece dislikes children, but Hetty's longing for books touches a chord and she stretches the rules to help her. Soon, Hetty's chief desire is to become a librarian like her friend. But with war on the horizon, their lives will never be the same.

Liverpool, 1940. When war comes to Britain, Jessica Wilson and her friend Ruby seize the opportunity to leave behind the orphanage they grew up in and start new lives in the NAAFI. With only forged papers as identification, the girls expect to be turned away but are delighted with an offer of work. For the first time in their lives they experience real independence, and it isn't long before they're spending their evenings enjoying the delights of Liverpool.

1850. When Opal Sharp finds herself and her younger siblings suddenly orphaned and destitute, she thinks things can get no worse. But soon three of them - including Opal - are struck down with the illness that took their father from them, and her brother Charlie is forced to make an impossible decision. Unable to afford a doctor, he knows the younger children will not survive. So, unbeknownst to Opal, Charlie takes their younger siblings to the workhouse, where he knows they will at least be fed and have a roof over their heads. Opal is heartbroken and struggles to forgive him. 

Jess and Nancy, nursing in France during the Great War, are very different girls with much in common. Both have lost their lovers in the trenches, so when the war is over, they return to a bleak future, nursing in Liverpool. Very soon, however, their paths diverge. Nancy marries an Australian and goes to live in the Outback whilst Jess marries a Liverpudlian. Both have children; Nancy's eldest is Pete, and Jess has a daughter, Debbie. 

Liverpool, 1934. Hester Lowe agrees to act as governess to spoiled, self-willed little Lonnie Hetherington-Smith when they leave India to live with Lonnie’s elderly aunt in Shaw Street, Liverpool. Hester speedily realises that her new employer dislikes her niece and means to make life uncomfortable for both of them. Things improve a little when they meet the poor but happy Bailey family, who live in a court off Heyworth Street. Hester likes Dick Bailey very much, but her employer does not permit 'followers', and Lonnie and young Ben Bailey are deadly enemies. 

 Liverpool, 1940. There comes a moment in every child’s life when they must learn to stand on their own two feet. For 15-year-old Ellie Lancton, that time has come all too soon. The death of her mother and the increase in air raids leaves Ellie alone and in grave danger. It’s not long before she is forced to leave her beloved Liverpool behind and cross the Mersey to seek refuge in the countryside. But as the war takes comforts away, so too does it bring new opportunities: for work, new friendships and perhaps a little love.... 

Nell Whitaker is 15 when war breaks out and her mother sends her to live with her Auntie Kath in a remote farmhouse on Anglesey. At first Nell hates it, but her friendship with Bryn, who works on the farm whilst waiting for his call-up papers, helps a lot. So when he leaves to join his ship, Nell is counting the days to his return. But her heart is broken when news reaches her that Bryn’s ship has been bombed and he has been drowned. Determined to bury her grief in hard work, Nell finds herself growing closer to Auntie Kath.

Kay Duffield knows everyone thinks she is marrying in haste, but with her fiancé about to leave the country, and her own duty with the WAAF about to begin, she believes in seizing happiness. But the precious few days she spends with her new husband soon fade into the background once she is thrown into her work.

Dana and Caitlin meet on the ferry from Ireland, both in search of new lives in Liverpool, having left their secrets behind in Ireland. But Dana is ambitious, and when the opportunity comes to own their own tearoom she persuades her friend to join her. No one is willing to rent property to a couple of girls, so when Caitlin’s new man-friend says he’ll back them, they are delighted. Soon the tearoom is thriving.

Claudia Muldoon and her sister, Jenny, live with their parents and their gran in her house in Blodwen Street. Both parents have good jobs and the family assume they are settled for life, but then Grandpa Muldoon has a seizure and begs his son to return to Ireland. In Ireland the Muldoons flourish and the girls love the freedom of their new life, though as they grow up, disadvantages become clear. Claudia has to find work, so both sisters return to Liverpool and to their old pal Danny, who welcomes them back with delight.