Jess and Nancy, nursing in France during the Great War, are very different girls with much in common. Both have lost their lovers in the trenches, so when the war is over, they return to a bleak future, nursing in Liverpool. Very soon, however, their paths diverge. Nancy marries an Australian and goes to live in the Outback whilst Jess marries a Liverpudlian. Both have children; Nancy's eldest is Pete, and Jess has a daughter, Debbie. 

Liverpool 1939: Olivia Campbell appears to have the perfect life. However, behind closed doors she lives in constant fear of her abusive father and has no support from her mother. Longing for love and affection, she begins a relationship with Ted, a young lad who works in her father's factory. But her family disapprove of the relationship and forbid them from seeing each other.

Marianne seems to have everything. She is married to a handsome Naval officer, Neil Sheridan. They have a daughter, Libby, and a beautiful home near Prince's Park in Liverpool. When war comes, Marianne takes war work and moves in with her mother, Mrs Wainwright, and younger sister. Neil disapproves because the Wainwrights live close to the docks, which are bound to be a bombing target, but Marianne is firm.

It's 1938, and Cadi is chosen to be Rose Queen in the annual Rose Fete. She is thrilled to be treated like royalty for the day. But deep down she is desperate to leave the Welsh mining community where she grew up. When war is declared, Cadi and her best friend, Poppy, see a chance to escape. Cadi leaves behind her parents and local boy Aled, whom she is meant to marry, for Liverpool.

Miranda Lovage and her mother have a blazing row when Arabella tells her daughter that she can no longer afford their present lifestyle. Miranda goes to bed angry and upset. When she awakes next morning, however, it is to find that her mother has disappeared. Miranda raises the alarm but everyone is baffled, and when searches fail to discover Arabella's whereabouts, Miranda is forced to live with her Aunt Vi and cousin Beth, who resent her presence and treat her badly.

Along a blacked-out wartime street a girl is scurrying, a basket on one arm. As sirens begin and bombs crash down, she is filled with panic and, with a heavy heart, abandons her burden in a sheltered doorway, meaning to return later. Even as she disappears in the resulting chaos, the bundle in the basket begins to wail.

Lottie and her mother, Louella, share a house in Victoria Court with Mr Magic and his son, Baz. Lottie is a child star, dancing and singing at the Gaiety Theatre; Louella acts as Max Magic's assistant. But a road accident causes Lottie to lose her memory. Then Lottie meets a boy with golden-brown eyes who calls her "Sassy" and accuses her of running away. It is after this meeting that the dreams start, dreams of another life, almost another world.

Jimmy Trewin and his little sister are devastated by their mother's death and horrified to find themselves entrusted to the care of a hated neighbour, Mrs Huxtable. They hope their father will rescue them when his ship comes into port but this does not happen. When Cyril Huxtable accuses them of theft and threatens a terrible revenge, they decide to leave Liverpool and try to find their mother's family in Wales.

Laura Collins is struggling to make a good life for her daughters, Tess and Tina. So when she is offered a good job, with accommodation, she is delighted. Life is very different for the Brewsters who live on Manor Farm in Herefordshire. Danny plans to marry one day so that he can take over the farm, whilst his cousin, Phil, longs to escape the world of farming as soon as possible. War changes all their plans.

Claudia Muldoon and her sister, Jenny, live with their parents and their gran in her house in Blodwen Street. Both parents have good jobs and the family assume they are settled for life, but then Grandpa Muldoon has a seizure and begs his son to return to Ireland. In Ireland the Muldoons flourish and the girls love the freedom of their new life, though as they grow up, disadvantages become clear. Claudia has to find work, so both sisters return to Liverpool and to their old pal Danny, who welcomes them back with delight.

Nell Whitaker is 15 when war breaks out and her mother sends her to live with her Auntie Kath in a remote farmhouse on Anglesey. At first Nell hates it, but her friendship with Bryn, who works on the farm whilst waiting for his call-up papers, helps a lot. So when he leaves to join his ship, Nell is counting the days to his return. But her heart is broken when news reaches her that Bryn’s ship has been bombed and he has been drowned. Determined to bury her grief in hard work, Nell finds herself growing closer to Auntie Kath.

Liverpool, 1934. Hester Lowe agrees to act as governess to spoiled, self-willed little Lonnie Hetherington-Smith when they leave India to live with Lonnie’s elderly aunt in Shaw Street, Liverpool. Hester speedily realises that her new employer dislikes her niece and means to make life uncomfortable for both of them. Things improve a little when they meet the poor but happy Bailey family, who live in a court off Heyworth Street. Hester likes Dick Bailey very much, but her employer does not permit 'followers', and Lonnie and young Ben Bailey are deadly enemies. 

It is the autumn of 1945 and identical twins Joy and Gillian Lawrence are on their way home to Liverpool, having been evacuated to Devonshire five years earlier. Their mother has been killed in the blitz but the girls hope that with their beloved father’s help they will be able to manage. All goes well until there is a terrible accident and Joy loses her sight. At first she is bitter and resentful whilst Gillian is racked with guilt.

A few days before Christmas Tess Williams rushes into Albert Payne's tobacconist shop, with two boys in hot pursuit, saying she's a thief. Albert chases the boys away, and though Tess does not realise it, this incident changes her life. Tess lives with her grandmother, Edie, in a small flat on Heyworth Street. She has recently returned from Bell Farm, where she was evacuated during the war. When the handsome Snowy White comes to her rescue she thinks her troubles are over, and returns to Bell Farm for a working holiday.

Dana and Caitlin meet on the ferry from Ireland, both in search of new lives in Liverpool, having left their secrets behind in Ireland. But Dana is ambitious, and when the opportunity comes to own their own tearoom she persuades her friend to join her. No one is willing to rent property to a couple of girls, so when Caitlin’s new man-friend says he’ll back them, they are delighted. Soon the tearoom is thriving.