Liverpool, 1940. When war comes to Britain, Jessica Wilson and her friend Ruby seize the opportunity to leave behind the orphanage they grew up in and start new lives in the NAAFI. With only forged papers as identification, the girls expect to be turned away but are delighted with an offer of work. For the first time in their lives they experience real independence, and it isn't long before they're spending their evenings enjoying the delights of Liverpool.

August 1940: As the Luftwaffe swarm over Liverpool, Shane Quinn decides to move his family back to the safety of Ireland. But his only child, the beautiful Dana, would rather stay and serve her country than flee to a foreign land. Determined to make it on her own, she joins the WAAF with newfound pals Patty and Lucy. There’s plenty of excitement to be had on a RAF station, even a chance or two at love.

When the Todds move into a flat on the Scotland Road, they are strangers to city life: their previous home was a canal barge. Harry gets a job as warehouse manager and his wife, Martha, works in a grocer’s shop whilst Seraphina trains as a teacher, Angela works in Bunney’s Department Store and young Evie starts at regular school. Then circumstances change, and Seraphina takes a job in Lyon’s Corner House. Customers vie for her favours, including an old friend, Toby.... 

Liverpool, 1917. When Irish seaman Michael Gallagher docks in Liverpool after years of fighting with the British Navy, he never expects to fall in love. But the moment he glimpses Stella Bennett, all thoughts of returning to his homeland vanish. Determined to be together, the young couple defy Stella’s parents’ wishes. But their plans to marry are soon derailed by the arrival of baby Ginny. Her crop of fiery red hair plants a seed of doubt in her father’s mind, and it’s not long before their world begins to fall apart.

It is a cold December night and Sylvie Dugdale is weeping as she walks by the Mersey. She fails to notice an approaching figure, and jumping to one side to avoid collision, she finds herself struggling in the ice-cold river. Constable Brendan O'Hara, just coming off duty, sees the girl's plight and dives in to rescue her. He is dazzled by her beauty but discovers that Sylvie's husband is in prison, and the closeness that Brendan soon longs for is impossible. But he is able to help her escape from Liverpool....

Liverpool, 1935. Kathy Kelling is coming home to Daisy Street from her first day at the High School, longing to tell her friend, Jane, all about it. The Kellings' life becomes a struggle when Kathy’s brother, Billy, has a serious accident. He needs constant attention, and Mrs Kelling must take in lodgers so that Kathy’s schooling does not suffer. When war breaks out, Kathy and Jane are forced to grow up fast. Kathy meets the handsome Alec Hewitt, but he is more attracted to blonde, bubbly Jane. But Fate has not yet finished with Kathy Kelling.... 

Bristol, 1939. School leaver Maisie Miles suspects her father, a small-time crook, has an ulterior motive for insisting she gets a job at the W. D. & H. O. Wills tobacco factory but keeps it to herself. She's befriended by effervescent Phyllis Mason and kind-hearted Bridget Milligan who take pity on her and take Maisie under their wing. But beneath their happy-go-lucky exteriors, they all harbour dreams and worries about what the future holds. 

 1936. Polly's guardian angel has to work overtime when her large family is forced to move from the countryside they love into central Liverpool. Money is desperately short, and with her mother working and her father sick, Polly is easily led astray by the handsome Sunny Andersen. But soon war looms, and Sunny joins the navy to train as a signaller. After the horrors of the May Blitz, Polly, too, decides she wants to help her country and goes into the WRNs. She hears that an old pal, Tad Donoghue from the Dublin slums, is now in the Royal Air Force.

Dympna Byrne lives a simple life with her family on the Connemara coast. She adores her father Micheál, and does her best to help her family by working hard and expecting little. But beneath the surface there are hidden secrets. Dympna’s mother idolises her clever eldest son, yet her attitude to Dympna is puzzling. So when her family find themselves in desperate need of money, it is Dympna who crosses the water to Liverpool to seek a better life. 

It wasn't a privileged childhood, but it was a happy one. Sybil and Lizzie Cream, brought up in a fisherman's cottage on the edge of the cold North Sea, were content to leave privilege where it belonged: with their friends the Wintertons. Christina Winterton was the same age as Sybil, and the two girls were inseparable, but it was Lizzie whom Ralph Winterton, three years older, found irresistible. Then war came to East Anglia, and so did Manchester-born Fenn Kitzmann, now of the American Army Air Force.

Emmy Dickens lives with her widowed mother in a neat house in neglected Nightingale Court, but Mrs Dickens has always impressed upon her daughter that her main aim in life must be to escape from the court. Emmy sees that marriage is her best way out, and when Peter Wesley, First Officer aboard a cruise ship, asks her to marry him, she is over the moon. Life goes well for the newlyweds; they set up home and start a family. But when Peter is killed and Emmy is left almost penniless, her problems begin.... 

1850. When Opal Sharp finds herself and her younger siblings suddenly orphaned and destitute, she thinks things can get no worse. But soon three of them - including Opal - are struck down with the illness that took their father from them, and her brother Charlie is forced to make an impossible decision. Unable to afford a doctor, he knows the younger children will not survive. So, unbeknownst to Opal, Charlie takes their younger siblings to the workhouse, where he knows they will at least be fed and have a roof over their heads. Opal is heartbroken and struggles to forgive him. 

Amy Logan’s family are poor but proud. They scrape a living by shrimping for the big Liverpool fish market, which Amy hates. It’s only because her beloved - and strict - mother rules her with a rod of iron that she mucks in. But Isobel Logan dies in childbirth, and Amy and her brothers start to run wild. Matters aren’t helped when her father marries Suzie Keagan from down the street. Until now, Suzie has managed to conceal a dislike for housekeeping, and she forces Amy to slave at chores. Desperate to escape, Amy leaves home to take her first job. 

One wild night in the 1930s, midwife Patty Peel is called to attend a birth on the opposite side of Liverpool. She pedals off into the storm and delivers a baby girl in a filthy slum dwelling, just as the mother dies. The drunk and violent father tells Patty to get rid of it so she takes the child away, meaning to deliver it to the nearest orphanage. However, Patty spent her entire childhood in an institution, except for the frequent occasions when she ran away, and cannot bear to hand the baby over. 

Paradise Row, London. December 1865. Snow is falling fast, and Sally Suggs is working tirelessly to bring in enough money to keep bread on the table. Her father, a skilled rag-and-bone man, has fallen ill, and now Sally has taken up his trade. But this is a man’s world and competition is fierce, and Sally’s rival, Finn Kelly, always seems to be one step ahead.