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With her four older sisters now married, it's Patience Shackleford's turn to take charge of her younger siblings' education. But given that Patience's most prodigious skill is lock picking, any abilities she passes on to her younger sisters are unlikely to provide any assistance in the drawing rooms of the genteel, especially as she has no interest in either high society, or horror of horrors… marriage. Indeed, her father the Reverend Augustus Shackleford is firmly of the opinion that the less society knows about his fifth daughter the better…

The Willows have been through a lot. Louise has devoted her life to caring for her disabled youngest daughter. Pete works abroad, almost never seeing his loved ones. Their eldest, Eliza, is burdened by all the secrets she's trying to keep from her overloaded family. Meanwhile, Patience observes the world while trapped in her own body. When the Willows are offered the opportunity for Patience to take part in a new gene therapy trial to cure her Rett syndrome, they face an impossible dilemma.