Feeling “fine” is not a plan. We sit down with Dr Sandeep Palakodeti —an Ivy League–trained internist who left elite institutions—to unpack why so much of healthcare reacts to disease instead of building durable health, and how treating your body like your ultimate asset can change the arc of your life. We dig into the core four foundations (sleep, diet, exercise, relationships), the hidden risks behind “normal for your age” labs, and the personalized strategies that help you extend your prime years, not just your lifespan.

Sandeep explains the gaps in standard panels and why markers like lipoprotein(a), ApoB, and early insulin resistance can quietly raise cardiovascular risk for decades. He shares a practical framework for advanced therapies—rapamycin, peptides, red light, hyperbaric oxygen—rooted in evidence, safety, access, and intent, with explicit stop criteria to avoid blind experimentation. We talk through what it takes to turn vague advice into precise action: strength training as a glucose sink, protein targets, VO2 max, and sleep protocols tailored to your biology and lifestyle.

We also explore the evolutionary case for a longer, more productive middle life. Wisdom tends to peak in the 50s and 60s, exactly when chronic disease often accelerates. With the right diagnostics, coaching, and accountability, it’s possible to keep the energy of a 30-year-old while preserving the judgment of a seasoned leader. From there, we shift to AI’s growing role in medicine: clinical copilots that surface patterns, agentic systems that handle routine care, and how empathy at scale could emerge alongside human guidance for high-stakes decisions.

If you’re ready to manage health with the same rigor as your wealth, this conversation offers a roadmap: better measurement, longer conversations, smarter tools, and a clear strategy that compounds over time. Subscribe, share with a friend, and tell us—what metric will you start tracking this week?

https://www.velocityhealthclinic.com/

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What if the core of fatigue, brain fog, and “getting old” is really an oxygen problem? We sit down with Brad Pitzele to unpack how exercise with oxygen therapy (EWOT) and red and near-infrared light can reboot cellular energy, open microcirculation, and dial down inflammation in a way that’s fast, practical, and measurable. Brad's story moves from autoimmune arthritis and melanoma risk to a sustainable routine that restored clarity and stamina—without spending hours in a chamber or crushing workouts.

We break oxygen down to first principles: aerobic vs anaerobic ATP, why lactic acid spikes when cells are starved, and how oxygen use declines about 1% per year after 25. From there, we get tactical. EWOT leverages exercise-driven vasodilation to flood plasma with oxygen, reaching capillary “nooks and crannies” red blood cells can’t. Hyperbaric oxygen raises partial pressure and helps specific cases like non-healing wounds or those unable to exercise, but EWOT’s 15-minute sessions, lower cost, and vessel-friendly physiology often make it the go-to choice for daily use.

Light therapy adds the second lever—demand. Red and near-infrared wavelengths signal mitochondria to take in more oxygen and make more ATP, supporting skin renewal, muscle recovery, and cognitive performance. Use them together for a supply-and-demand loop: EWOT first, then light for longevity; light first, then EWOT for performance. We also cover safe ramp-ups to avoid Herxheimer reactions, how to start if you’re deconditioned, what biomarkers to track, and myths to ditch about “no pain, no gain” and red light overdosing.

If you’ve wondered whether brain fog can lift, whether energy can return without heroic protocols, or whether oxygen and light can support long COVID, Lyme, or cognitive decline strategies, this conversation offers clear steps and honest limits. Subscribe, share with someone who needs hope and a plan, and leave a review with your top question so we can tackle it next.

https://www.onethousandroads.com/

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What if the most powerful health checkup you ever had happened at your kitchen table, not a clinic? We sit down with Dr. Natasha Milinkovic, a UK physician who moved from the front lines of vascular surgery and emergency medicine to the leading edge of preventive care, to explore how lab‑grade at‑home blood testing and intelligent coaching can change outcomes before a crisis hits.

We start with the problem he saw repeatedly: people arriving late with preventable chronic disease. That urgency drives a practical roadmap for what to measure and why. You’ll hear a clear breakdown of high‑value biomarkers—HbA1c for glucose trends, ApoB and the ApoB to ApoA1 ratio for cardiovascular risk, and thyroid markers for therapy tuning—and why total cholesterol alone often misleads. Tosh explains how accuracy is maintained through CLIA‑accredited labs and transparent methods, addressing trust in a post‑Theranos world. We also dig into biological age: how markers like hs‑CRP, HbA1c, and sex hormones push it up or down, and the specific lifestyle levers that can nudge it younger over the next 90 days.

Then we open the hood on Sai, an AI longevity expert trained on a clinician‑curated knowledge base. Instead of scraping the noisy web, Sai reads your longitudinal labs, medications, and context to deliver personalized, evidence‑based guidance. Think trend detection for creeping glucose, stubborn ApoB, or hidden inflammation—and concrete next steps that you can take today. Looking ahead, Tosh shares what’s next: home hardware that brings instant panels into your routine and a vision of predictive health where alerts trigger action long before symptoms do.

If you want to cut through hype, track the markers that matter, and pair credible data with smart coaching, this conversation will give you the playbook. Subscribe, share with a friend who’s optimizing their health, and leave a review with the one biomarker you plan to track this year.

Note: I am an advisor to Siphox but I only advise those companies whose products I would use for myself and family.

https://siphoxhealth.com/lufkin

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What if the most powerful “sugars” aren’t fuel at all, but messages your immune system has been waiting to hear? We sit down with Dr John Lewis, a former professor whose lab uncovered striking cognitive improvements in people with moderate to severe Alzheimer’s after 12 months on a formula built from aloe and rice bran polysaccharides. The science takes us beyond calories and cravings into complex carbohydrates as signaling molecules—shaping inflammation, immune balance, and possibly neuroplasticity.

We unpack polysaccharides 101, separating starch from functional giants like aloe acemannan and rice bran compounds. You’ll hear how these dense, 3D structures can influence CD4/CD8 ratios, natural killer cell activity, TNF-alpha, VEGF, and even CD14 cells tied to neural repair. The clinical story is matched by lived moments from caregivers who witnessed language and daily function return. We also dig into why conventional funding passed on this line of research, the dominance of amyloid-focused paradigms, and the gap between public talk about nutrition and what actually gets resourced.

If you’ve wondered whether food could deliver these effects, we cover the practical realities: aloe gel is mostly water, rice bran is milled off white rice, and even daily brown rice may not supply meaningful doses—especially for older adults managing chronic inflammation. That’s where concentrated, third-party tested, GMP-produced supplementation can fit: small grams-per-day inputs that favor immune modulation without stimulants or sugar spikes. Along the way we explore prevention, aging, and how steady immune signaling may guard brain health long before problems start.

Subscribe for more deep, evidence-led conversations on brain health, nutrition science, and longevity. If this episode challenged your view of “sugar,” share it with a friend and leave a review to help others find the show.

https://drlewisnutrition.com/ Use "Lufkin10" for 10% off.

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What if the root cause of our most devastating chronic diseases—from Alzheimer's and cardiovascular disease to diabetes and cancer—could be traced back to the same cellular structures? And what if these tiny organelles hold the key to understanding how we age and potentially extending our healthspan?

Dr. Hemal Patel, Professor in the Department of Anesthesiology at UC San Diego School of Medicine, takes us on a fascinating journey into the world of mitochondria. Far from being mere "powerhouses of the cell" as we learned in school, these ancient bacterial descendants play sophisticated roles as gatekeepers of cellular life and death, potential drivers of cell differentiation, and central players in understanding chronic disease.

When functioning properly, mitochondria form interconnected communities within our cells—appearing like strings of pearls in heart cells, which devote a remarkable 30% of their volume to these energy-generating structures. But when these connections break down, disease follows. Dr. Patel explains how every chronic condition can be viewed through the lens of energy imbalance, with mitochondria at the center of this critical equation.

Perhaps most exciting is the breakthrough technology Dr. Patel's team has developed: a simple blood test called MeScreen that can assess mitochondrial function without invasive biopsies. Using just a few drops of blood, this revolutionary approach reveals each person's unique mitochondrial signature, offering personalized insights that could transform how we approach health optimization and disease prevention.

Whether you're curious about the fundamental biology of life, seeking to understand chronic disease, or interested in cutting-edge approaches to longevity, this conversation will forever change how you think about the trillions of tiny organelles powering every aspect of your existence. Discover why supporting these ancient symbionts might be the missing link in our pursuit of longer, healthier lives.

https://mescreen.com/cart/47561239626013:1?discount=&ref=emssndtq (Use the code MITOHEALTH100 for $100 off)

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Unlock the secrets to a longer, healthier life with our special guest, Kevin Ellis, the Bone Coach. This episode dives deep into the critical importance of bone health, far beyond just keeping you upright. From blood cell production to immune system support and mineral storage, Kevin explains how your bones play a vital role in your overall well-being. Learn why early bone density scans (DEXA scans) are crucial and how conditions like osteoporosis and osteopenia can silently impact your life quality without proactive monitoring.

Explore the hidden connections between inflammation, aging, and chronic diseases and discover how everyday factors like gluten, seed oils, and insulin resistance can erode your skeletal strength. Kevin shares actionable advice on diet, physical activity, and nutrient intake, emphasizing the power of weight-bearing exercises and resistance training. Especially important for older women, these strategies can dramatically enhance bone density and quality, making a significant difference in your health as you age.

Finally, Kevin debunks common myths about osteoporosis treatment, advocating for a holistic approach over traditional medications like calcium and vitamin D supplements. From gut health to personalized exercise plans, he unveils a comprehensive blueprint for preventing bone loss and improving bone quality naturally. Plus, don't miss out on Kevin’s Stronger Bones programs and a free masterclass offering invaluable resources to start your journey toward stronger, healthier bones. Join us and take the first step towards a resilient, active future!

https://bonecoach.com/

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What if you could see your inflammation—and your pace of aging—from your kitchen table? We sit down with Bob Messerschmidt, an optical engineer turned Apple platform architect who helped seed Apple Health and the Apple Watch, then left to build a simple at-home device that measures ESR, a century‑old inflammation marker with fresh relevance for longevity.

We unpack why chronic inflammation drives heart disease, stroke, neurodegeneration, and metabolic dysfunction, and why a single, trackable number can change behavior more than any abstract advice. You’ll hear a clear breakdown of ESR vs CRP: how CRP reacts fast to single-protein changes while ESR integrates multiple inflammatory pathways over several days, often acting like a steadier signal for lifestyle experiments. We explore compelling evidence that ESR rises with age in Western populations—functioning as a biological clock—yet flattens in agrarian cohorts, underscoring how environment and habits accelerate “inflammaging.”

Beyond theory, we get practical. Our guest shares what actually lowers ESR: meaningful weight loss, GLP‑1 therapies, omega‑3 rich fish, better sleep, daily movement, strength training, stress control, and even tart cherry juice. We talk about the design constraints that make wrist sensors tricky, why Apple prioritizes validation over speed, and how bringing blood-based testing into the home removes friction that once sidelined ESR in centralized lab workflows. With more than ten thousand tests across a diverse user base, the team is preparing anonymized insights and research in underserved communities to show which interventions move the needle in the real world.

If you want a reliable, weekly feedback loop that ties your choices to measurable change, this conversation maps the path. Subscribe, share with a friend who cares about longevity, and leave a review to help more people discover smarter ways to measure and lower inflammation.

https://corhealth.com/

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What if everything you've been taught about nutrition is not just wrong, but actively harming your health? Cary Kelly's story might make you question your most basic assumptions about food and wellness.

Cary grew up in a household religiously following conventional dietary guidelines—low-fat everything, margarine instead of butter, minimal red meat, and plenty of "heart-healthy" grains. Yet by his late 40s, his health was deteriorating rapidly. Chronic inflammation ravaged his body, extra weight accumulated around his middle, and simple activities became painful ordeals. When his arm suddenly went numb during a walk, Cary feared the worst.

That frightening episode became his turning point. Desperate for solutions after being told he would simply have to "live with" his conditions, Cary reluctantly tried a new diet that seemed to contradict everything he'd been taught about nutrition. The results were nothing short of miraculous—within just three days, the inflammation that had plagued him for years began to subside. As Cary describes it, "It's like it had been raining inside my body every day for a decade and then, all of a sudden, the sun came out."

Now, Cary has distilled his culinary expertise (from 28 years in the restaurant industry) into Carnicopia, a cookbook featuring simple, accessible meat-based recipes anyone can prepare. His approach isn't about perfection—it's about finding what works for your body and challenging the nutritional dogma that may be keeping you sick.

Whether you're struggling with chronic inflammation, carrying extra weight that won't budge, or simply curious about why meat-based diets are transforming thousands of lives, Cary's story offers both inspiration and practical guidance.

https://healthrecoverywithcarykelly.com/

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