Feeling “fine” is not a plan. We sit down with Dr Sandeep Palakodeti —an Ivy League–trained internist who left elite institutions—to unpack why so much of healthcare reacts to disease instead of building durable health, and how treating your body like your ultimate asset can change the arc of your life. We dig into the core four foundations (sleep, diet, exercise, relationships), the hidden risks behind “normal for your age” labs, and the personalized strategies that help you extend your prime years, not just your lifespan.

Sandeep explains the gaps in standard panels and why markers like lipoprotein(a), ApoB, and early insulin resistance can quietly raise cardiovascular risk for decades. He shares a practical framework for advanced therapies—rapamycin, peptides, red light, hyperbaric oxygen—rooted in evidence, safety, access, and intent, with explicit stop criteria to avoid blind experimentation. We talk through what it takes to turn vague advice into precise action: strength training as a glucose sink, protein targets, VO2 max, and sleep protocols tailored to your biology and lifestyle.

We also explore the evolutionary case for a longer, more productive middle life. Wisdom tends to peak in the 50s and 60s, exactly when chronic disease often accelerates. With the right diagnostics, coaching, and accountability, it’s possible to keep the energy of a 30-year-old while preserving the judgment of a seasoned leader. From there, we shift to AI’s growing role in medicine: clinical copilots that surface patterns, agentic systems that handle routine care, and how empathy at scale could emerge alongside human guidance for high-stakes decisions.

If you’re ready to manage health with the same rigor as your wealth, this conversation offers a roadmap: better measurement, longer conversations, smarter tools, and a clear strategy that compounds over time. Subscribe, share with a friend, and tell us—what metric will you start tracking this week?

https://www.velocityhealthclinic.com/

Continue this conversation on SubStack: https://robertlufkinmd.substack.com

Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/
Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/
Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin

Web: https://robertlufkinmd.com/
X: https://x.com/robertlufkinmd
Youtube: https://www.youtube.com/robertLufkinmd
Instagram: https://www.instagram.com/robertlufkinmd/
LinkedIn: https://www.linkedin.com/in/robertlufkinmd/
TikTok: https://www.tiktok.com/@robertlufkin
Threads: https://www.threads.net/@robertlufkinmd
Facebook: https://www.facebook.com/robertlufkinmd
Blu...

What if the core of fatigue, brain fog, and “getting old” is really an oxygen problem? We sit down with Brad Pitzele to unpack how exercise with oxygen therapy (EWOT) and red and near-infrared light can reboot cellular energy, open microcirculation, and dial down inflammation in a way that’s fast, practical, and measurable. Brad's story moves from autoimmune arthritis and melanoma risk to a sustainable routine that restored clarity and stamina—without spending hours in a chamber or crushing workouts.

We break oxygen down to first principles: aerobic vs anaerobic ATP, why lactic acid spikes when cells are starved, and how oxygen use declines about 1% per year after 25. From there, we get tactical. EWOT leverages exercise-driven vasodilation to flood plasma with oxygen, reaching capillary “nooks and crannies” red blood cells can’t. Hyperbaric oxygen raises partial pressure and helps specific cases like non-healing wounds or those unable to exercise, but EWOT’s 15-minute sessions, lower cost, and vessel-friendly physiology often make it the go-to choice for daily use.

Light therapy adds the second lever—demand. Red and near-infrared wavelengths signal mitochondria to take in more oxygen and make more ATP, supporting skin renewal, muscle recovery, and cognitive performance. Use them together for a supply-and-demand loop: EWOT first, then light for longevity; light first, then EWOT for performance. We also cover safe ramp-ups to avoid Herxheimer reactions, how to start if you’re deconditioned, what biomarkers to track, and myths to ditch about “no pain, no gain” and red light overdosing.

If you’ve wondered whether brain fog can lift, whether energy can return without heroic protocols, or whether oxygen and light can support long COVID, Lyme, or cognitive decline strategies, this conversation offers clear steps and honest limits. Subscribe, share with someone who needs hope and a plan, and leave a review with your top question so we can tackle it next.

https://www.onethousandroads.com/

Continue this conversation on SubStack: https://robertlufkinmd.substack.com

Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/
Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/
Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin

Web: https://robertlufkinmd.com/
X: https://x.com/robertlufkinmd
Youtube: https://www.youtube.com/robertLufkinmd
Instagram: https://www.instagram.com/robertlufkinmd/
LinkedIn: https://www.linkedin.com/in/robertlufkinmd/
TikTok: https://www.tiktok.com/@robertlufkin
Threads: https://www.threads.net/@robertlufkinmd
Facebook: https://www.facebook.com/robertlufkinmd
Blu...

What if the most powerful health checkup you ever had happened at your kitchen table, not a clinic? We sit down with Dr. Natasha Milinkovic, a UK physician who moved from the front lines of vascular surgery and emergency medicine to the leading edge of preventive care, to explore how lab‑grade at‑home blood testing and intelligent coaching can change outcomes before a crisis hits.

We start with the problem he saw repeatedly: people arriving late with preventable chronic disease. That urgency drives a practical roadmap for what to measure and why. You’ll hear a clear breakdown of high‑value biomarkers—HbA1c for glucose trends, ApoB and the ApoB to ApoA1 ratio for cardiovascular risk, and thyroid markers for therapy tuning—and why total cholesterol alone often misleads. Tosh explains how accuracy is maintained through CLIA‑accredited labs and transparent methods, addressing trust in a post‑Theranos world. We also dig into biological age: how markers like hs‑CRP, HbA1c, and sex hormones push it up or down, and the specific lifestyle levers that can nudge it younger over the next 90 days.

Then we open the hood on Sai, an AI longevity expert trained on a clinician‑curated knowledge base. Instead of scraping the noisy web, Sai reads your longitudinal labs, medications, and context to deliver personalized, evidence‑based guidance. Think trend detection for creeping glucose, stubborn ApoB, or hidden inflammation—and concrete next steps that you can take today. Looking ahead, Tosh shares what’s next: home hardware that brings instant panels into your routine and a vision of predictive health where alerts trigger action long before symptoms do.

If you want to cut through hype, track the markers that matter, and pair credible data with smart coaching, this conversation will give you the playbook. Subscribe, share with a friend who’s optimizing their health, and leave a review with the one biomarker you plan to track this year.

Note: I am an advisor to Siphox but I only advise those companies whose products I would use for myself and family.

https://siphoxhealth.com/lufkin

FASTING CHALLENGE: https://robert-lufkin.mykajabi.com/fast?ref=RL

Continue this conversation on SubStack: https://robertlufkinmd.substack.com

Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/
Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/
Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin

Web: https://robertlufkinmd.com/
X: https://x.com/robertlufkinmd
Youtube: https://www.youtube.com/robertLufkinmd
Instagram: https://www.instagram.com/robertlufkinmd/
LinkedIn: https://www.linkedin.com/in/robertlufkinmd/
TikTok: https://www.tiktok.com/@robertlufkin
Threads: https://www.threads.net/@robertlufkinmd
Facebook: https://www.facebook.com/robertlufkinmd
Blu...