What if the same symptoms we see in combat veterans — the broken sleep, the irritability, the brain fog — were already quietly spreading through the healthiest, highest-performing people you know?

In this episode of Health Longevity Secrets, Robert Lufkin MD sits down with Neil Markey — a former US Army Special Operations captain from the 75th Ranger Regiment turned McKinsey consultant, now the co-founder and CEO of Beckley Retreats and a Harvard Chan School student researching psychedelic-assisted integrated health. Neil walks us through his own journey out of post-combat trauma, the neuroscience of why psilocybin opens a rare window of neuroplasticity in the adult brain, and why he believes this work belongs upstream as preventative medicine for the well.

CHAPTERS:
00:00 — Introduction
02:34 — From Mathlete to 75th Ranger Regiment
02:50 — Iraq, WMDs, and the Pretense of War
03:16 — Two Afghanistan Tours as a Ranger Captain
07:14 — How Meditation Reached Him First
11:49 — The Peer Group Where Everyone Was Secretly Breaking
12:25 — Why the Environment Always Wins
15:15 — The Neuroplasticity Window Psychedelics Open
17:18 — Amanda Feilding and the Beckley Foundation
18:20 — Why Set and Setting Decide the Outcome
20:58 — The Fresh Snowfall Metaphor for the Brain
24:09 — Preventative Medicine for the Well, Not Just the Broken
32:18 — The Real Safety Profile of Psilocybin
33:27 — Beckley as a Public Benefit Corporation
39:38 — Bringing Rigor at Harvard Chan
40:12 — Jamaica, the Netherlands, and the US Legal Path
45:04 — A Green Beret's Son Finally Came to Him
46:34 — Why Awe Beats Burnout

KEY TAKEAWAYS:
• Psilocybin opens a measurable window of neuroplasticity in the adult brain
• Set, setting, and integration determine outcomes far more than the compound itself
• Psilocybin is non-toxic with low incident rates when used in controlled environments
• The "betterment of the well" use case may be as transformative as clinical treatment
• Oregon and Colorado have legalized supervised use; New Mexico and Massachusetts are next
• Chronic stress in high-performers replicates many PTSD-like symptoms
• Awe, empathy, and connection are measurable outcomes — and they beat burnout

STUDIES & SOURCES MENTIONED:

• Neil Markey — Beckley Retreats (use code LUFKIN for 10% off)
• Beckley Foundation — Amanda Feilding's psychedelic research institute
• Dr. Robin Carhart-Harris — UCSF Psychedelics Division
• Johns Hopkins Center for Psychedelic & Consciousness Research
• Oregon Psilocybin Services — first US regulated program
• JAMA Psychiatry meta-analysis on psilocybin for depression (2023)
• Harvard T.H. Chan School of Public Health

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Five longevity beliefs that millions have followed for decades have just been overturned by the latest research. Some of these will surprise you.

In this explainer, Robert Lufkin MD walks through five of the most widely believed longevity myths — and what the most recent science actually says about each one. From genetics and middle age to antioxidants, alcohol, and caloric restriction, the evidence has shifted dramatically.

CHAPTERS:
00:00 — Introduction
00:32 — Myth 1: Your Genes Determine How Long You Live
01:51 — Myth 2: It's Too Late to Change After Middle Age
03:24 — Myth 3: Antioxidant Supplements Prevent Disease
05:22 — Myth 4: Moderate Alcohol Is Good for You
07:04 — Myth 5: Caloric Restriction Is King
08:50 — The Real Framework: Quality Beats Quantity
09:18 — Final Takeaway

KEY TAKEAWAYS:
• Genetics accounts for at most 25–50% of how long you live
• Quitting smoking before 40 eliminates ~90% of excess mortality risk
• Antioxidant supplements have no benefit and may increase mortality
• The protective J-curve for moderate alcohol disappears once you correct for the "sick quitter" effect
• Caloric restriction's primate magic was rescuing animals from a high-sugar control diet
• Diet quality matters more than diet quantity

STUDIES & SOURCES MENTIONED:
• Herskind et al., Human Genetics 1996 — 2,872 Danish twin pairs heritability of longevity
• Jha et al., NEJM 2013 — 21st-century smoking cessation and life expectancy
• Saint-Maurice et al., JAMA Network Open 2019 — Adult life-course physical activity and mortality
• Bjelakovic et al., Cochrane 2012 — Antioxidant supplements for prevention of mortality
• Zhao et al., JAMA Network Open 2023 — Daily alcohol intake and all-cause mortality meta-analysis
• Mattison et al., Nature Communications 2017 — Caloric restriction in rhesus monkeys (NIA / Wisconsin reconciliation)

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What if the most dangerous metabolic inflection point in a woman's entire life is the one we've been taught to simply endure?

In this episode of Health Longevity Secrets, Robert Lufkin MD sits down with Dr. Mayoni Gooneratne — a London-trained former NHS colorectal and pelvic floor surgeon, now the founder of Human Health and vice-chair of the British College of Functional Medicine. Dr. Mayoni walks us through why she walked away from the operating theater and how perimenopause — not menopause — is the real window where metabolic disease, cognitive decline, and cardiovascular risk are either quietly programmed in or actively reversed.

CHAPTERS:
00:00 — Introduction
01:47 — From NHS Surgeon to Functional Medicine Founder
06:53 — Dr. Mayoni's Own Perimenopause Story
07:12 — Her Mother's Menopause-to-Diabetes Cascade
08:43 — The Cortisol Trap: Three Kids Under Three
10:39 — The Surgical Mentor Who Changed Everything
12:27 — What Functional Medicine Actually Is
12:52 — Root Cause vs "Treat and Street" Medicine
18:08 — The Timeline Aha Moment Patients Never Forget
21:09 — The Human Health Roadmap: Gut, Hormones, Mitochondria
24:19 — The Thrive Program for Perimenopause
25:42 — Body Fit: 16-Week Ketogenic Metabolic Reset
29:14 — Why You Shouldn't Stay in Ketosis Long-Term
33:20 — Why Normal Vitamin D Isn't Optimal Vitamin D
35:02 — Where AI Fits in Functional Medicine
36:03 — The Ovarian Age Clock Every Woman Should Know About
37:56 — The NHS-Private Divide in Chronic Disease
40:09 — Eat Better, Move Better, Sleep Better
42:18 — Where to Find Dr. Mayoni

KEY TAKEAWAYS:
• Perimenopause — not menopause — is the real metabolic inflection point for women
• Loss of estrogen can trigger type 2 diabetes and cardiovascular disease within months
• Chronic high-cortisol lives prime the perimenopause crash
• "Normal" vitamin D isn't optimal vitamin D — aim for ~100
• Nutritional ketosis works as a 16-week reset, not a permanent lifestyle
• New ovarian age clocks let women plan for reproductive aging precisely
• Pregnancy glucose tolerance results preview perimenopausal metabolic risk

STUDIES & SOURCES MENTIONED:

• Dr. Mayoni Gooneratne — Human Health clinic
• British College of Functional Medicine
• Institute for Functional Medicine
• Future Patient digital magazine and congress
• Ovarian age clocks / reproductive aging research (Nature)
• North American Menopause Society — hormone therapy position statement

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