In the 1980s, a suspected serial killer preyed on women in small towns located on the banks of the Mississippi River until the murders abruptly ceased and went unsolved. In 2006, 26 years later, a cold case detective and producer on the set of "Cold Case Files" unknowingly began to connect the dots that would crack the case while discussing the murder of Deborah Sheppard, a Southern Illinois University student whose death had remained a mystery since 1982.

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This serial killer preyed on women in South Central Los Angeles for a staggering 25 years, leaving a community traumatized and overlooked.

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A heavily pregnant woman is viciously attacked by a woman obsessed with making the unborn child her own. A couple cling to the rafters of their home as Hurricane Ike unleashes its fury on them. A woman fends off a man who has hidden in her family home for days before brutally attacking her.

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When 25-year-old school teacher Christy Mirack is found brutally murdered in her Lancaster, Pennsylvania, apartment in 1992, there is no shortage of suspects. Twenty-six years after her murder, cold case detectives get a break when the sister of the killer uploads her DNA profile to a public genealogy website. This development leads to the arrest of a former disc jockey, Raymond Rowe (who performed under the name DJ Freez) who accepted a plea deal and admitted his guilt.

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The Monster: Police are convinced they have caught the rapist/murderer of an elderly woman, even after DNA evidence is exculpatory. They keep him in custody until an identical incident occurs. Later, the culprit is caught in the act of attacking a teen and brought to justice on several cases shown to have the same DNA.

A Cousin's Promise: Twenty-one years after her cousin's death, Cheryl Cowans prods Reynoldsburg, Ohio to reopen the case. Once again, DNA appears to link the victim and murderer, but legal maneuvering puts him in prison for only five years.

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A woman's psychotic boyfriend attacks her with a meat cleaver. A man and his father are dumped in an icy Alaskan river. An intruder sexually assaults a woman and cuts her throat after she gets home from shopping.

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When Sherry Leighty goes missing in 1999, her family is left wondering how a dedicated mother of three could vanish without a trace. A decade later, the cold case heats up when Sherry's sister launches a social media campaign to help solve her sister's mysterious disappearance. An online tip unearths the truth and a sinister family secret.

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The longest running cold case of a law enforcement officer in the United States was the murder of Sheriff's Lt. Joe Clark.

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