• Jan 30 2026 This Week in Cardiology
    Jan 30 2026

    Listener feedback, huge news in the rapidly expanding world of PFA AF Ablation, obesity, and a beautiful trial studying an AI-enhanced diagnostic tool in the office are the topics discussed by John Mandrola, MD, in this week's podcast.

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I Listener Feedback

    • Risk-Based TEE Omission in PVI 10.1016/j.hrthm.2025.04.056 External Link

    II PFA News

    • BEAT PAROX-AF trial https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaf1115/8436829
    • Life-Threatening Delayed Myocardial Ischemia and Malignant Arrhythmias Occurring After PFA https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.125.077983
    • Heart Rhythm TV: Life-Threatening Delayed Myocardial Ischemia and Malignant Arrhythmias https://www.youtube.com/watch?v=M-npoLKmRa4
    • MAUDE Adverse Event report https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfmaude/detail.cfm?mdrfoi__id=23733351&pc=QZI

    III Obesity trends

    • US State-Level Obesity Trends 1990-2022 and Forecasted to 2035 https://jamanetwork.com/journals/jama/fullarticle/2844495

    IV New Tools in the Office

    • TRICORDER Trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02156-7/fulltext

    You may also like:

    The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

    Questions or feedback, please contact news@medscape.net

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    28 mins
  • Jan 23 2026 This Week in Cardiology
    Jan 23 2026

    Listener feedback, the value of procedural volume for TAVR and MTEER, ventricular arrhythmia in older athletes, and the Goldilocks time horizon for predicting and modifying CV risk are the topics John Mandrola, MD, discusses in this week's podcast.

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I Procedural Volume and Outcomes for TAVI and M-TEER

    • Operator Procedural Volumes and Outcomes for TAVR and MTEER https://jamanetwork.com/journals/jamacardiology/fullarticle/2843740

    II Ventricular Arrhythmia in Older Male Endurance Athletes

    Myocardial Fibrosis May Raise Arrhythmia Risk in Older Male Endurance Athletes

    https://www.medscape.com/viewarticle/myocardial-fibrosis-may-raise-arrhythmia-risk-older-male-2026a10001y0

    • Timing and Relationship of VA With Exercise Patterns in Older Male Endurance Athletes https://doi.org/10.1093/eurjpc/zwag021

    III Predicting Cardiac Risk and Statin Use

    • 30-Year ASCVD Risk Among US Adults Aged 30-59 https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.125.012348

    You may also like:

    The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

    Questions or feedback, please contact news@medscape.net

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    30 mins
  • Jan 16, 2026 This Week in Cardiology
    Jan 16 2026

    Some great listener feedback, one of the best studies of the year in atrial fibrillation and heart failure, imaging to exclude left atrial thrombus, and a truly amazing first cardiac procedure are the topics John Mandrola, MD, discusses in this week's podcast.

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I Listener Feedback

    On Fish Oil and AF

    • Links between omega-3 fatty acids and AF https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.058596
    • Omega-3 and risk of AF https://doi.org/10.1016/j.pcad.2024.11.003
    • DHA vs EPA in reducing vulnerability to AF https://www.ahajournals.org/doi/10.1161/CIRCEP.112.971515

    II Withdrawal of HF Therapy AF rhythm control

    The AF is Gone, the EF Is Up. Can You Stop the HF Meds?

    https://www.medscape.com/viewarticle/af-gone-ef-can-you-stop-hf-meds-2024a1000h6o

    • Effect of beta-blockers in patient with HF plus AF -- meta-analysis https://pubmed.ncbi.nlm.nih.gov/25193873/
    • TRED HF Trial 10.1016/S0140-6736(18)32484-X External Link
    • WITHDRAW-AF Trial https://academic.oup.com/eurheartj/article/47/2/250/8238240

    III ICE or TEE Before AF Ablation

    • ICE vs TEE in Atrial Fibrillation Ablation https://jamanetwork.com/journals/jamacardiology/fullarticle/2839370

    IV The Vector Procedure

    • Percutaneous Aorto-Coronary Bypass Graft: the VECTOR procedure https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.125.016130

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    The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

    Questions or feedback, please contact news@medscape.net

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    31 mins
  • Jan 09 2026 This Week in Cardiology
    Jan 9 2026

    The limits of knowing coronary artery disease anatomy, fish oil and AF risk, a new drug for PSVT, and maybe I was wrong about a drug for AF conversion (the RAFF4 trial). These are the topics John Mandrola, MD, discusses in this week's podcast.

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I Prediction of CAD is hard — even if you have anatomy

    • CCTA in Prediction of First Coronary Events https://jamanetwork.com/journals/jama/fullarticle/2841255

    II Fish Oil and AF (and as a bonus we learn again about analytic flexibility)

    • Are Fish Oils on the Hook for AF Risk?

    https://www.medscape.com/viewarticle/995290

    • Omega-3 and Fish Oil Use With Risk of AF https://www.ahajournals.org/doi/full/10.1161/JAHA.125.043031
    • Effect of Long-Term Marine Omega-3 Fatty Acids on the Risk of AF https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.055654
    • RESPECT-EPA Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.065520
    • Association Between Omega-3 Fatty Acids and AF: Meta Analysis https://link.springer.com/article/10.1007/s10557-021-07204-z
    • Fish Oil Supplements and Risk of AF https://academic.oup.com/eurjpc/article/29/14/1911/6679610
    • Editorial: Fish Oil Supplements and AF Risk https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057464

    III A New Drug for PSVT

    • FDA Approval https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-drug-type-abnormally-fast-heart-rhythm
    • RAPID trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00776-6/fulltext

    IV AF Conversion with Vernakalant

    • RAFF4 Trial https://www.bmj.com/content/391/bmj-2025-085632.long
    • Editorial: Rapid Cardioversion for Acute AF https://www.bmj.com/content/391/bmj.r2264

    VI A Quick Note on HFpEF

    Med Op-Ed: Avalanche Survival, HFpEF Skepticism, and More

    https://www.medscape.com/viewarticle/med-op-ed-avalanche-survival-hfpef-skepticism-and-more-2026a1000012

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    The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

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    28 mins
  • Dec 19 2025 This Week in Cardiology
    Dec 19 2025

    The MI paradox of risk scores, the CELEBRATE trial of a new subcutaneous glycoprotein IIb/IIIA inhibitor (with its funny endpoint), the SURPASS CVOT trial, and the bad story of andexanet alfa are the topics John Mandrola, MD, discusses in this week's podcast.

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I What do risk scores mean for individuals? Or perhaps a better question: Is a first MI preventable?

    • Limitations of Screening in Predicting First MI https://www.jacc.org/doi/10.1016/j.jacadv.2025.102361
    • Sudden Death Due to Cardiac Arrhythmias https://www.nejm.org/doi/abs/10.1056/NEJMra000650
    • UMC Amsterdam group (EHJ) https://academic.oup.com/eurheartj/article/46/38/3762/8181058

    II CELEBRATE Trial

    • CELEBRATE Trial https://evidence.nejm.org/doi/full/10.1056/EVIDoa2500268

    III SURPASS CVOT Trial Published

    Aug 01, 2025 This Week in Cardiology Podcast

    https://www.medscape.com/viewarticle/1002781

    • SURPASS-CVOT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2505928
    • REWIND Trial 10.1016/S0140-6736(19)31149-3 External Link

    IV FDA Pulls Andexanet Alfa From the Market

    • ANNEXA 4 https://www.nejm.org/doi/10.1056/NEJMoa1814051
    • ANNEXA I https://www.nejm.org/doi/full/10.1056/NEJMoa2313040
    • Richard Buka Tweet https://x.com/richardbuka/status/2001045834050216327?s=20

    V Mandrola's Top Cardiovascular Stories of 2025

    https://www.medscape.com/viewarticle/mandrolas-top-10-cardiovascular-stories-2025-2025a1000yuh

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    Questions or feedback, please contact news@medscape.net

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    36 mins
  • Dec 12 2025 This Week in Cardiology
    Dec 12 2025

    An elegant study in post-TAVI atrioventricular block, a PSA for my structural colleagues, revascularization in women, and a CTO PCI trial are the topics John Mandrola, MD, discusses in this week's podcast.

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I AV Block After TAVR

    Heart Blocks During vs After TAVR Show Distinct Patterns

    https://www.medscape.com/viewarticle/heart-blocks-during-vs-after-tavr-show-distinct-patterns-2025a1000ypp

    • Mechanisms Underlying Alterations in Cardiac Conduction After TAVR https://jamanetwork.com/journals/jamacardiology/fullarticle/2842748

    II Related PSA Announcement to My Structural Colleagues

    III Revascularization Strategies in Women with Severe Chronic CAD

    Women With Chronic Severe CAD Fare Better With CABG vs PCI

    https://www.medscape.com/viewarticle/women-chronic-severe-cad-fare-better-cabg-vs-pci-2025a1000ygd

    • PCI vs CABG in Women With Chronic CAD https://doi.org/10.1093/eurheartj/ehaf806
    • PCI vs CABG - Meta-Analysis of 4 RCTs https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02334-5/abstract
    • CABG vs Drug-Eluting Stent Implantation for CAD - Meta-Analysis https://www.jacc.org/doi/10.1016/j.jcin.2016.10.008
    • RECHARGE trial https://therechargetrial.com/

    IV A CTO PCI RCT – But don't get your hopes up

    • Early vs Late-Staged PCI After Subintimal Tracking and Re-entry for CTO https://doi.org/10.1016/j.jacc.2025.09.1598
    • DECISION CTO trial https://pubmed.ncbi.nlm.nih.gov/30813758/
    • National Inpatient Sample Database PCI CTO Associated With Higher Mortality https://pubmed.ncbi.nlm.nih.gov/37356643/

    V Mandrola's Top 10 Stories

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    28 mins
  • Dec 05 2025 This Week in Cardiology
    Dec 5 2025

    Less is more after PCI, the TARGET-FIRST trial, a negative blood pressure trial that is actually positive, aspirin vs OAC for bleeding, AEDs, and Factor XI is not dead yet are the topics discussed by John Mandrola, MD, on this week's podcast.

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I Less is More: TARGET-FIRST

    • TARGET-FIRST Trial https://www.nejm.org/doi/10.1056/NEJMoa2508808
    • STOPDAPT-2 ACS Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2789701

    II A Negative Trial That Is Actually Positive

    • The RETREAT-FRAIL Study https://www.nejm.org/doi/full/10.1056/NEJMoa2508157

    III Major Bleeding With Aspirin vs Apixaban

    • Subanalysis of ARTESiA https://jamanetwork.com/journals/jamacardiology/fullarticle/2841075
    • ARTESiA Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2310234
    • AVERROES Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1007432

    IV High Value Interventions – The AED

    • Experts Call for AED Placement on All Commercial Aircraft https://www.medscape.com/viewarticle/experts-call-aed-placement-all-commercial-aircraft-2025a1000xzf
    • In-Flight Sudden Cardiac Arrest and AED Use 10.1016/j.cjca.2025.10.010 External Link

    V Factor XI Inhibitors – OCEANIC STROKE trial

    • Bayer Press Release on Asundexian https://www.bayer.com/en/us/news-stories/oceanic-stroke

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    The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

    Questions or feedback, please contact news@medscape.net

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    30 mins
  • Nov 21 2025 This Week in Cardiology
    Nov 21 2025

    Listener feedback, huge news in the world of carotid disease with the CREST-2 publication, prasugrel beats ticagrelor again, and a big coffee trial are the topics John Mandrola, MD, discusses in this week's podcast.

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I Listener Feedback

    • Complete Revascularization for Acute MI Meta-analysis https://doi.org/10.1016/S0140-6736(25)02170-1

    II A Sea Change in the Treatment of Carotid Artery Disease — CREST-2 Published

    • ECST-2 https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(25)00107-3/fulltext
    • SPACE-2 https://pubmed.ncbi.nlm.nih.gov/36115360/
    • CREST-2 Trial www.nejm.org/doi/full/10.1056/NEJMoa2508800
    • CREST Protocol paper https://pmc.ncbi.nlm.nih.gov/articles/PMC5987521/

    III Prasugrel Beats Ticagrelor in High-Risk Patients With Diabetes After PCI https://www.medscape.com/viewarticle/prasugrel-beats-ticagrelor-high-risk-patients-diabetes-after-2025a1000wbt

    • PLATO trial https://www.nejm.org/doi/full/10.1056/NEJMoa0904327
    • Ticagrelor or prasugrel vs clopidogrel in PCI https://eurointervention.pcronline.com/article/ticagrelor-or-prasugrel-versus-clopidogrel-in-patients-undergoing-percutaneous-coronary-intervention-for-chronic-coronary-syndromes
    • ISAR-REACT 5 trial https://www.nejm.org/doi/full/10.1056/NEJMoa1908973

    IV Another Coffee and AF study

    Can Coffee Cut the Risk for Atrial Fibrillation?

    https://www.medscape.com/viewarticle/can-coffee-cut-risk-atrial-fibrillation-2025a1000w11

    A Coffee a Day to Keep the AFib Away? The DECAF Trial Discussed https://www.medscape.com/viewarticle/coffee-day-keep-afib-away-decaf-trial-discussed-2025a1000v5z

    • DECAF trial https://jamanetwork.com/journals/jama/fullarticle/2841253

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    29 mins