The Killer Gene That FOUGHT BACK
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The Killer Gene That FOUGHT BACK
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Summary
In this deep dive, we break down the journey of the PIM Kinase target. We explore the complex PIM1 molecular mechanism, examine why first-generation pan-PIM inhibitors like AZD-1208 faced safety issues and a lack of monotherapy efficacy, and reveal the final clinical verdict of the Terminated and Completed Phase 1 studies.
📖 Video Chapters:
0:00 - Intro
1:05 - Biobanks Associations for PIM1
22:18 - PIM1 Gene
39:00 - PIM1 Protein
52:52 - PIM1 Known Drugs and Clinical Trials
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