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Paradigm Pulse

Paradigm Pulse

By: Paradigm Medical Communications LLC
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Listen to audio from accredited CME activities from Paradigm Medical Communications, featuring expert faculty discussions and the latest clinical insights. Visit the link in each episode description to access the full activity and claim CME credit.© 2026 Paradigm Medical Communications, LLC Science
Episodes
  • New and Emerging Mechanisms in the Treatment of Systemic Lupus Erythematosus

    New and Emerging Mechanisms in the Treatment of Systemic Lupus Erythematosus
    Aug 3 2026

    Please CLICK HERE, or paste the following URL into your browser, (https://activities.paradigmmc.com/1460P) to view the full CME activity and claim credit for your participation.

    • (00:00) - Welcome and Introduction
    • (05:54) - B Cell Targets in Lupus
    • (07:58) - Targeting BAFF
    • (11:55) - Dual Targeting APRIL and BAFF
    • (15:11) - B-Cell Depletion Via the BAFF Receptor
    • (17:57) - Type II Anti-CD20
    • (28:20) - Bispecific T-Cell Engagers
    • (32:51) - CAR-T Cells in SLE

    B cells play a major role in the pathology of systemic lupus erythematosus (SLE), and several treatments have focused on blocking activation or depleting large subsets of B cells based on surface markers. From anti-CD20 antibodies to chimeric antigen receptor (CAR) T cells, varying depths of B-cell depletion have demonstrated a range of efficacies and durations of response. In addition, these treatments vary in administration, preparation, ease of use, and potential adverse effects. The faculty will provide an engaging discussion on the categories of emerging B-cell therapies and their potential use in SLE.
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    39 mins
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