What if aging and reproduction were engineering problems, not biological limits?

In this episode, Amanda Cassatt sits down with AthenaDAO founder Laura Minquini to unpack how reproductive biotech could transform same-sex reproduction, family structures, and the future of population growth.

Laura explains how AthenaDAO and the DeSci movement are using crypto to fund research that has previously not been prioritized by the FDA or mainstream pharma, arguing that reproductive biotech is one of the most consequential frontiers in modern science, from ovarian tissue cryopreservation and in vitro gametogenesis (IVG) to artificial wombs that could radically extend not just fertility, but women’s healthspan.

She details how ovarian tissue cryopreservation works, a surgical procedure originally developed for cancer patients where ovarian tissue is removed, frozen, and later reimplanted to restore ovarian function. She describes how this technique is now being offered electively, what it realistically enables, and why it may be the most direct path to delaying menopause.

The two dig into why menopause drives systemic aging, why women live longer but spend more years in disease, and how reproductive biology has been sidelined by traditional biotech funding.

Timestamps:

00:00 Why the future of biotech isn’t evenly distributed

02:05 Ovarian tissue cryopreservation and extending fertility

06:30 Why menopause affects the entire body—not just reproduction

10:45 Longevity, ovarian function, and why women live longer with more disease

15:10 Why women’s health research is so underfunded

19:40 Clinical trials, fertility risk, and why female data is missing

24:30 Artificial wombs: science fiction or near-term reality?

29:00 In vitro gametogenesis (IVG) and the future of egg creation

34:20 Radical reproductive unlocks and societal implications

39:30 Why controversial technologies need human-first framing

44:50 Decentralized science (DeSci) and crypto-funded research

49:20 Why crypto struggles with long-term scientific timelines

53:40 The AthenaDAO business model and token-equity hybrid approach

58:10 Menopause prediction, HRT, and what Laura uses personally

01:01:30 Moonshots, legacy, and redefining women’s reproductive futures

Subscribe to Endgame: https://www.youtube.com/@endgamepodcast

Laura on X: https://x.com/LauraMinquini

AthenaDAO on X: https://x.com/athena_DAO_

Amanda on X: https://x.com/amandacassatt

Serotonin on X: https://x.com/serotonin

Endgame on Spotify: https://open.spotify.com/show/6iSvbKOJWoEPiAoGmiulkd

Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440

Substack: https://substack.com/@UCInZsV3L1nDGoFjxoNUnPQQ

What is the future of Arbitrum now that L1 Ethereum is becoming scalable?

In this episode, Amanda Cassatt sits down with Offchain Labs and Arbitrum co-founder Steven Goldfeder. Arbitrum began as Ethereum’s scaling answer, borrowing its security to add more bandwidth, faster confirmations, and better UX. As Ethereum solves the scalability problem that was Arbitrum's original raison d’être, Steven explains Arbitrum's next frontier: customization and institutional onboarding onto Ethereum, by providing privacy and KYC that won't become available at L1 anytime soon.

The two discuss the specific ways and regions Robinhood is already - though invisibly to users - using Arbitrum, the precise path RWAs are taking to gain consumer adoption, and which traditional financial products are poised to come onchain. Steven clarifies where he aligns and departs from Vitalik's articulation of what Ethereum is for, and he tells us what he believes will happen when Ethereum grows beyond its original decentralization-first vision.

Times are evolving, and institutions aren’t guaranteed to take on the cypherpunk ideology, but so long as the core system is preserved, Goldfeder believes that there are a lot of benefits to mass onboarding.

Timestamps:

00:00 Scaling Ethereum: The Role of Arbitrum

09:29 Customization for Institutions: Arbitrum's Unique Offerings

12:43 Compliance and Privacy: Institutional Needs in DeFi

16:21 The Philosophy of Ethereum: Freedom vs. Compliance

22:39 The Future of Ethereum: KYC and Institutional Adoption

25:03 The Evolution of Use Cases on Arbitrum

31:44 Arbitrum's DAO: Governance and Decision-Making

43:50 Balancing Power: Democracy vs. Monarchy in DAOs

55:24 The Future of Arbitrum: Growth and User Experience

Subscribe to Endgame: https://www.youtube.com/@endgamepodcast

Steven on X: https://x.com/sgoldfed

Offchain Labs on X: https://x.com/OffchainLabs

Amanda on X: https://x.com/amandacassatt

Serotonin on X: https://x.com/serotonin

Endgame on Spotify: https://open.spotify.com/show/6iSvbKOJWoEPiAoGmiulkd

Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440

Substack: https://substack.com/@UCInZsV3L1nDGoFjxoNUnPQQ

What happens when crypto stops optimizing purely for profit and starts optimizing for people, planet, and long-term coordination?

In this episode, Amanda Cassatt sits down with Gitcoin founder Kevin Owocki to discuss Ethereum’s public goods, swallowing the Green Pill, and what onchain coordination will look like in the future.

Owocki maps the cultural fault lines inside Ethereum: the libertarian and cypherpunk roots, the rise of hyper-financialized degen culture, and the parallel effort to build something different: a regenerative ecosystem that funds public goods, sustains open source, and solves coordination failures instead of reproducing them.

The two unpack what Green Pill really means and the choice it asks of builders, how Gitcoin funded $70 million in public goods and why grants and vibes aren’t enough anymore.

Timestamps:

00:00 Introduction to Regen and Degen

02:57 The Green Pill Movement

06:13 Public Goods in Ethereum

09:10 Funding Challenges in the Ethereum Ecosystem

12:07 Comparing Ethereum to Traditional Governments

15:00 The Evolution of Public Goods Funding

17:48 Incentive Alignment and the Tragedy of the Commons

21:04 Building Proofs for Public Goods

24:11 Ethereum's Unique Approach to Public Goods

26:48 Meditations on Moloch and Coordination Failures

29:39 Exploring Moloch and Ginsberg's Influence

30:04 Addressing Coordination Failures in Ethereum

34:48 The Future of Capitalism and Its Alternatives

39:40 Balancing Different Forms of Capital

45:03 Navigating Financial Nihilism Among Youth

47:41 Success Stories in Building Parallel Institutions

Subscribe to Endgame: https://www.youtube.com/@endgamepodcast

Kevin on X: https://x.com/owocki

Amanda on X: https://x.com/amandacassatt

Serotonin on X: https://x.com/serotonin

Endgame on Spotify: https://open.spotify.com/show/6iSvbKOJWoEPiAoGmiulkd

Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440

Substack: https://substack.com/@UCInZsV3L1nDGoFjxoNUnPQQ