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#foodrecall #foodallergy #consumeralert #childsafety #fda

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A new study suggests that popular GLP-1 drugs such as Ozempic, Wegovy and Zepbound may be linked to a higher risk of male-pattern hair loss in men who are already genetically susceptible.

NYU dermatologists analyzed genetic data tabulating both GLP-1 receptor activity and androgenetic alopecia, that is hair loss. They found that genetically predicted higher GLP-1 receptor activity was associated with about a 7 percent higher risk of male-pattern hair loss. The association remained after accounting for hypertension, insulin resistance and lower testosterone.

Interesting result, but the study only pinpoints an association. The researchers did not actually follow men taking Ozempic or Wegovy and measure any resultant hair loss. They used an inherited genetic variation in the GLP-1 receptor gene as a proxy for increased GLP-1 activity.

*However, where there is smoke, there may be fire. Hair shedding has already been reported by GLP-1 users but is often attributed to rapid weight loss. This study raises the possibility that GLP-1 signaling itself may be the cause. Future studies are needed to determine the exact mechanism, which men are at risk, and whether the same relationship exists in women.

References on my website.

#Ozempic #Wegovy #GLP1 #HairLoss #MedicalResearch

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A compound naturally found in foods like spinach, almonds and sweet potatoes may unexpectedly worsen the intestinal inflammation suffered by people with Crohn’s disease and ulcerative colitis. That compound is oxalate, already known to potentiate the development of kidney stones.

Gastroenterologists at the University of North Carolina studied people with inflammatory bowel disease and find that those with Crohn’s disease have higher levels of oxalate in their stool, even when their plant-food intake is similar to that of healthy controls. Investigating the cause, they show that the two proteins necessary for transporting oxalate out of the intestine, SLC26A2 and SLC26A3, are consistently reduced in those with IBD.

They went on to study the phenomenon use mouse models of IBD. Adding oxalate to the diet intensified colitis. In one model, mice receiving supplemental oxalate were 60 percent less likely to survive.

*The researchers emphasize that this new information does not mean people with IBD should stop eating vegetables or other healthy plant foods, but they certainly should avoid those with higher oxalate levels. In the future, it may be possible to identify those patients with lower levels of oxalate-transporting proteins as candidates for replacement therapy as well as personalized, lower-oxalate diets or treatments with oxalate-digesting gut bacteria.

References on my website.

#IBD #CrohnsDisease #UlcerativeColitis #GutHealth #MedicalResearch