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David Armstrong and Richie Abel recorded brand new interviews at ASBMR 2026 in Boston, Massachusetts. In this fourth episode the lads chatted to three more guests.

Dr Jude Bubbear (Consultant in Metabolic Bone Disease, Royal National Orthopaedic Hospital) describes real-world data from the UK early access programme for burosumab in X-linked hypophosphataemia. Ten patients over 65 had reductions in pain and stiffness and improvements in quality of life.

Guillaume Mabilleau (Associate Professor, Université d’Angers) explains how GLP-1 receptor agonists act on bone mainly through enzymatic collagen cross-linking. In animal models semaglutide also reduced grip strength even after adjusting for weight loss.

Nour El Houda Goucem (Professional Research Assistant, CU Anschutz) describes the genotyping, histology, DEXA and micro-CT work behind mouse studies of bone. Nour also explains how research experience is preparing her for medical school.

Join us for more interviews from the conference in the next part.

David Armstrong and Richie Abel recorded brand new interviews at ASBMR 2026 in Boston, Massachusetts. In this third episode the lads chatted to three more guests.

Tony Keaveny (Professor Emeritus of Mechanical Engineering and Bioengineering, UC Berkeley, and Founder and Chief Science Officer, O.N. Diagnostics) explains how biomechanical CT uses finite element analysis of existing CT scans to estimate bone strength and fracture risk.

Olivia White (PhD candidate, Purdue University) describes how alcohol use disorder and type 2 diabetes combined produced the lowest bone mineral density and bone strength in a mouse model.

Gabrielle Dudek (PhD student, CU Anschutz) discusses how formate and taurine supplementation improved bone size and structure in a mouse model of homocystinuria.

Join us for more interviews from the conference in the next part.

David Armstrong and Richie Abel recorded brand new interviews at ASBMR 2026 in Boston, Massachusetts. In this second episode the lads chatted to three more guests.

Lora Giangregorio (Professor of Kinesiology and Health Sciences and Chair in Bone Health and Exercise Science, University of Waterloo) gives practical advice on resistance, balance and impact exercise for bone health and on returning to exercise safely after a fracture.

Dr Prem Yadav (Instructor in Medicine, Massachusetts General Hospital and Harvard Medical School) describes how activating PTH1R signalling improved bone growth in a mouse model of achondroplasia.

Ella Chen (PhD candidate, CU Anschutz) explains how genetic studies in humans and mice suggest that early onset and age-related intervertebral disc degeneration have distinct genetic causes.

Join us for more interviews from the conference in the next part.

For the first time, BoneUP crosses the Atlantic.

David Armstrong and Richie Abel recorded brand new interviews at ASBMR 2026 in Boston, Massachusetts. In this first episode the lads chatted to three guests.

Christopher Hernandez is Professor of Orthopaedic Surgery and Bioengineering at the University of California, San Francisco. He explains how the gut microbiome influences the material properties of bone matrix in mice.

Dr Marie-Eva Pickering is a consultant in rheumatology at the University Hospital Clermont-Ferrand. She discusses how pain is phenotyped in fibrous dysplasia.

Melissa Cuevas is a PhD student at CU Anschutz. She presents her work on the genetics of adolescent idiopathic scoliosis.

Join us for more interviews from the conference in the next part.

The lads sit down together and Richie interviews David about a career in osteoporosis care. David describes his move from lupus research to setting up the Fracture Liaison Service at the Western Trust in 2008. He explains how the service works and why advice to GPs, pharmacists and other specialists takes up much of a bone specialist's week. He also discusses the very high risk category in the National Osteoporosis Guideline Group guidance. David explains why romosozumab would be his first choice for these patients and why teriparatide is less convincing at the hip.

Prof David Armstrong is a Consultant Rheumatologist at the Western Trust in Londonderry and Visiting Professor at the Nutrition Innovation Centre for Food and Health at Ulster University. He built the Trust's Fracture Liaison Service in 2008 and still runs it. He is also a member of the National Osteoporosis Guideline Group.

The lads jetted off to sunny Girona for the European Calcified Tissue Society Congress, where they caught up with some brilliant boneheads about the latest in bone research.

In Part 2, we chat to Stuart Ralston about the TOPAZ trial for Brittle Bone Disease, Emma Duncan about the ASBMR and ECTS Societies and Kass Javaid about his conference highlights.

The lads jetted off to sunny Girona for the European Calcified Tissue Society Congress, where they caught up with some brilliant boneheads about the latest in bone research.

In Part 3, we chat to Friederike Schulte about combining physical loading with bone drugs, Mathilde Palmier about steroids weakening bone-building cells, and Melina Guillon about repurposing drugs for osteoporosis.

The lads jetted off to sunny Girona for the European Calcified Tissue Society Congress, where they caught up with some brilliant boneheads about the latest in bone research.

In Part 2, we chat to Marc McKee about biomineralization, Lidia Zhtynk and Laura Vintura about brittle bone disease (osteogenesis imperfecta), Ken Poole about the ECTS debate on the AI tools for osteoporosis and Judy Keen about the ASBMR and the Annual Meeting in Boston later this year.