In this episode, Dr. Eric Osansky explores how the autoimmune component of Graves’ disease and Hashimoto’s thyroiditis may contribute to bone loss, even when thyroid hormone levels are well controlled. While hyperthyroidism is known to increase bone turnover and the risk of osteoporosis, Dr. Eric explains why thyroid autoimmunity itself deserves attention. He also shares his personal experience of discovering low bone density on a DEXA scan in 2024, years after achieving remission from Graves’ disease, and why he wishes he had evaluated his bone health sooner.

Dr. Eric reviews research examining the relationship between elevated thyroid antibodies, chronic inflammation, and bone metabolism. He discusses how TPO antibodies and TSH receptor antibodies may be associated with reduced bone mineral density and increased fracture risk, along with the roles of inflammatory cytokines, regulatory T cells, Th17 cells, and the balance between osteoblasts and osteoclasts. He also explains why the research is not entirely consistent and why an association between thyroid antibodies and bone loss does not necessarily prove that lowering those antibodies will improve bone density.

Free resources for your thyroid health

Get your FREE Thyroid and Immune Health Restoration Action Points Checklist at SaveMyThyroidChecklist.com

High-Quality Nutritional Supplements For Hyperthyroidism and Hashimoto’ s
Have you checked out my new ThyroSave supplement line? These high-quality supplements can benefit those with hyperthyroidism and Hashimoto’s, and you can receive special offers, along with 10% off your first order, by signing up for emails and text messages when you visit ThyroSave.com.

Do You Want Help Saving Your Thyroid?

Get free access to hundreds of articles and blog posts: https://www.naturalendocrinesolutions.com/articles/all-other-articles

Watch Dr. Eric’s YouTube channel: https://www.youtube.com/c/NaturalThyroidDoctor/videos

Join Dr. Eric’s Graves’ disease and Hashimoto’s group: https://www.facebook.com/groups/saveyourthyroid

Take the Thyroid Saving Score Quiz: https://quiz.savemythyroidquiz.com/sf/237dc308

Read all of Dr. Eric’s published books:
http://savemythyroid.com/thyroidbooks

Work with Dr. Eric:
https://savemythyroid.com/work-with-dr-eric/

In this episode, Dr. Eric Osansky welcomes back Dr. Stephanie Gray to discuss her latest book, Your Hormone Blueprint, and her approach to hormone replacement therapy, hormone optimization, and healthy aging. Drawing from her experience in functional medicine and her personal journey through perimenopause, Dr. Stephanie explains why she believes hormone therapy deserves a more individualized approach. She discusses the history of concerns surrounding hormone replacement therapy, the Women’s Health Initiative study, and the importance of understanding the potential benefits and risks of treatment rather than assuming hormones are appropriate for everyone.

Dr. Stephanie and Dr. Eric explore the differences between hormone replacement therapy (HRT) and hormone optimization therapy (HOT), along with the role of blood testing and DUTCH testing in evaluating hormone levels and estrogen metabolism. They discuss estrogen, progesterone, testosterone, cortisol, and thyroid hormones, including how stress, nutritional deficiencies, gut health, and lifestyle factors may influence hormone balance. Dr. Stephanie also shares her perspective on breast cancer concerns, bioidentical hormones, and the potential role of nutrients such as NAC, glutathione, resveratrol, and DIM in supporting estrogen metabolism. The conversation also covers hormone changes in men, fertility considerations with testosterone replacement, and why symptoms of perimenopause can overlap with those of Graves’ disease.

To take the Save My Thyroid Quiz visit www.savemythyroid.com/quiz

Free resources for your thyroid health

Get your FREE Thyroid and Immune Health Restoration Action Points Checklist at SaveMyThyroidChecklist.com

High-Quality Nutritional Supplements For Hyperthyroidism and Hashimoto’ s
Have you checked out my new ThyroSave supplement line? These high-quality supplements can benefit those with hyperthyroidism and Hashimoto’s, and you can receive special offers, along with 10% off your first order, by signing up for emails and text messages when you visit ThyroSave.com.

Do You Want Help Saving Your Thyroid?

Get free access to hundreds of articles and blog posts: https://www.naturalendocrinesolutions.com/articles/all-other-articles

Watch Dr. Eric’s YouTube channel: https://www.youtube.com/c/NaturalThyroidDoctor/videos

Join Dr. Eric’s Graves’ disease and Hashimoto’s group: https://www.facebook.com/groups/saveyourthyroid

Take the Thyroid Saving Score Quiz: https://quiz.savemythyroidquiz.com/sf/237dc308

Read all of Dr. Eric’s published books:
http://savemythyroid.com/thyroidbooks

Work with Dr. Eric:
https://savemythyroid.com/work-with-dr-eric/

In this episode, Dr. Eric Osansky explores T3-predominant Graves’ disease, a less common form of Graves’ disease in which T3 levels are disproportionately elevated compared to T4. While most people with Graves’ disease have elevated levels of both thyroid hormones, some experience persistently high T3 with normal or even low T4. Dr. Eric explains how the thyroid normally produces and converts these hormones, why increased TSH receptor stimulation may contribute to this unusual pattern, and how genetics and thyroid-stimulating antibodies may also play a role.

Dr. Eric discusses why T3-predominant Graves’ disease can be particularly challenging to manage with antithyroid medications such as methimazole. In some cases, treatment may lower T4 too much while T3 remains relatively high. He shares an example from his practice involving fluctuating TSH levels and explains how stimulating and blocking TSH receptor antibodies may contribute to changes in thyroid function. He also reviews research suggesting that long-term remission with antithyroid medication alone may be more difficult in people with T3-predominant Graves’ disease, while emphasizing the importance of considering the underlying autoimmune process.

In the post-episode chat, Dr. Eric expands on T4-to-T3 conversion, the different types of TSH receptor antibodies, limitations of antibody testing, and whether natural agents such as bugleweed and L-carnitine may have a role. He also explains why a single thyroid panel isn't enough to identify a persistent pattern and why treatment decisions need to be individualized. If you want a clearer, more balanced understanding of T3-predominant Graves’ disease and why T3 and T4 don't always respond to treatment in the same way, you'll get a lot out of this episode.

To take the Save My Thyroid Quiz visit www.savemythyroid.com/quiz

Free resources for your thyroid health

Get your FREE Thyroid and Immune Health Restoration Action Points Checklist at SaveMyThyroidChecklist.com

High-Quality Nutritional Supplements For Hyperthyroidism and Hashimoto’ s
Have you checked out my new ThyroSave supplement line? These high-quality supplements can benefit those with hyperthyroidism and Hashimoto’s, and you can receive special offers, along with 10% off your first order, by signing up for emails and text messages when you visit ThyroSave.com.

Do You Want Help Saving Your Thyroid?

Get free access to hundreds of articles and blog posts: https://www.naturalendocrinesolutions.com/articles/all-other-articles

Watch Dr. Eric’s YouTube channel: https://www.youtube.com/c/NaturalThyroidDoctor/videos

Join Dr. Eric’s Graves’ disease and Hashimoto’s group: https://www.facebook.com/groups/saveyourthyroid

Take the Thyroid Saving Score Quiz: https://quiz.savemythyroidquiz.com/sf/237dc308

Read all of Dr. Eric’s published books:
http://savemythyroid.com/thyroidbooks

Work with Dr. Eric:
https://savemythyroid.com/work-with-dr-eric/