If you're trying to conceive, undergoing IVF or navigating recurrent pregnancy loss, understanding progesterone could help you make sense of your fertility journey.

In this episode of Fertility Untamed Dr Sylvia Ross and Dr Rebecca Mackenzie-Proctor break down one of the most talked-about hormones in fertility treatment: progesterone. From embryo implantation and IVF success to early pregnancy and miscarriage, they explain what progesterone does, when it's used and what the evidence actually tells us.

Progesterone plays a vital role in preparing the uterine lining for implantation and supporting early pregnancy. But when should it be taken? Can taking more improve your chances of getting pregnant? And what does a low progesterone blood test really mean?

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Episode Topics Include:
• What is progesterone?: Understand how this essential hormone works during ovulation, implantation and early pregnancy.

• Progesterone and IVF: How progesterone is used during ovarian stimulation, fresh embryo transfers and frozen embryo transfers.

• The implantation window: Why timing matters when preparing the uterine lining for an embryo.

• Low progesterone levels: Why progesterone blood tests can be difficult to interpret and why a single result may not tell the whole story.

• When should you take progesterone? Why starting progesterone at the wrong time may affect your chances of conception.

• Progesterone supplements and side effects: The different formulations available and what patients may experience.

• Can progesterone prevent miscarriage? What the PROMISE and PRISM trials found about progesterone treatment and pregnancy loss.

• Progesterone in early pregnancy: When treatment may be continued and what the evidence says about supporting an ongoing pregnancy.

• Personalised fertility treatment: Why progesterone treatment isn't one-size-fits-all and how clinicians approach individual patient needs.

Whether you're trying to conceive naturally, preparing for IVF, considering a frozen embryo transfer or looking for answers after pregnancy loss, this conversation will help you better understand the role of progesterone in fertility.

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