The (in)famous PREDIABETES guest stars on today's episode. Lots to talk about here and we could probably make like 12 more prediabetes episodes but we tried to get it all in one for ya.

We mention the book Burnout by Emily Nagoski PhD and Amelia Nagoski DMA. Find it here: https://www.burnoutbook.net/

We would LOVE to make episodes that YOU want to hear. What diabetes topics are you dying to know more about? Let us know :)

Reach out to us!

Email us your questions here: glucoseriotpod@gmail.com

Find out more about Kelly at www.sixnutritionanddiabetes.com

Find out more about Erin at www.erinphillipsnutrition.com

DISCLAIMER: We are dietitians and diabetes educators but we are not YOUR dietitians and diabetes educators. The information provided in this podcast is not intended as individualized medical advice, nor is it a substitute for professional medical expertise or treatment. If you have a medical concern, go to your health care provider or seek other professional medical treatment.

Here are the sources we used for this episode:

1. Sandforth A, Vazquez Arreola E, Hanson RL, et al. Prevention of type 2 diabetes through prediabetes remission without weight loss. Nat Med. 2025;31(10):3330-3340. doi:10.1038/s41591-025-03944-9 — Nature Medicine, 2025, volume 31, issue 10, pages 3330-3340 uni-heidelberg
2. Sandforth A, von Schwartzenberg RJ, Vazquez Arreola E, et al. Mechanisms of weight loss-induced remission in people with prediabetes: a post-hoc analysis of the randomised, controlled, multicentre Prediabetes Lifestyle Intervention Study (PLIS). Lancet Diabetes Endocrinol. 2023;11(11):798-810. doi:10.1016/S2213-8587(23)00235-8 — Lancet Diabetes Endocrinol, November 2023, 11(11):798-810 nih
3. Knowler WC, Barrett-Connor E, Fowler SE, et al; Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346(6):393-403. doi:10.1056/NEJMoa012512 — N Engl J Med 2002;346(6):393-403 healthdata
4. Diabetes Prevention Program Research Group. Long-term effects of lifestyle intervention or metformin on diabetes development and microvascular complications over 15-year follow-up: the Diabetes Prevention Program Outcomes Study. Lancet Diabetes Endocrinol. 2015;3(11):866-875. doi:10.1016/S2213-8587(15)00291-0 — PMCID PMC4623946, Lancet Diabetes Endocrinol 2015;3(11)

Still the most commonly drug prescribed for people with diabetes (and the third most commonly prescribed drug in the US!) but what is it and what is it doing? Kelly and Erin talk through the very beginning of it's story to where we are now and everything in between.

References:

1. LaMoia TE, Shulman GI. Cellular and Molecular Mechanisms of Metformin Action. Endocr Rev. 2021;42(1):77-96. doi:10.1210/endrev/bnaa023
2. American Diabetes Association Professional Practice Committee for Diabetes. 9. Pharmacologic Approaches to Glycemic Treatment: Standards of Care in Diabetes-2026. Diabetes Care. 2026;49(Suppl 1):S183-S215. doi:10.2337/dc26-S009
3. Pavlo Petakh, Kamyshna I, Kamyshnyi A. Effects of metformin on the gut microbiota: A systematic review. Mol Metab. 2023 Nov;77:101805. doi: 10.1016/j.molmet.2023.101805. Epub 2023 Sep 9. PMID: 37696355; PMCID: PMC10518565.
4. Bu Y, Peng M, Tang X, et al. Protective effects of metformin in various cardiovascular diseases: Clinical evidence and AMPK-dependent mechanisms. J Cell Mol Med. 2022;26(19):4886-4903. doi:10.1111/jcmm.17519

LINKS:

Email us your questions here: glucoseriotpod@gmail.com

Find out more about Kelly at www.sixnutritionanddiabetes.com

Find out more about Erin at www.erinphillipsnutrition.com

DISCLAIMER: We are dietitians and diabetes educators but we are not YOUR dietitians and diabetes educators. The information provided in this podcast is not intended as individualized medical advice, nor is it a substitute for professional medical expertise or treatment. If you have a medical concern, go to your health care provider or seek other professional medical treatment.

Insulin resistance is one of the most widely used but misunderstood terms in diabetes care, and getting it wrong can send you straight into more restriction, more stress, and worse blood sugar swings. Erin Phillips and Kelly Six break down what it actually is, how to think about it without the usual fear-based nonsense, and what might actually help your body.

LINKS:

Email us your questions here: glucoseriotpod@gmail.com

Find out more about Kelly at www.sixnutritionanddiabetes.com

Find out more about Erin at www.erinphillipsnutrition.com

DISCLAIMER: We are dietitians and diabetes educators but we are not YOUR dietitians and diabetes educators. The information provided in this podcast is not intended as individualized medical advice, nor is it a substitute for professional medical expertise or treatment. If you have a medical concern, go to your health care provider or seek other professional medical treatment.