EP 92 Integrins: The Conversation Between Cells and Fascia
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EP 92 Integrins: The Conversation Between Cells and Fascia
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Cells are constantly receiving information not only through chemical messengers such as hormones, neurotransmitters, and growth factors, but also through their physical environment. In this episode, we explore integrins: specialized cell-surface receptors that help link the extracellular matrix to the cell’s internal scaffolding. I discuss how integrins participate in adhesion, movement, cellular organization, and mechanosensing and why a cell’s local environment, including matrix composition, structure, stiffness, and loading, can influence its behavior. All this gives us one more reason to keep fascia healthy!
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References mentioned:
Anderson, L. R., Owens, T. W., & Naylor, M. J. (2014). Structural and mechanical functions of integrins. Biophysical reviews, 6(2), 203–213. https://doi.org/10.1007/s12551-013-0124-0
Fagerholm S. C. (2022). Integrins in Health and Disease. The New England journal of medicine, 387(16), 1519–1521. https://doi.org/10.1056/NEJMcibr2209679