Evie spent her early years left outside on the step. With a drunk for a father and a neglectful mother, all little Evie has ever craved is a safe home and a normal existence. Her young eyes had seen so much, but this never tainted her spirit. If it wasn't for her best friend, Gary, and a friendly dog called Whisky, Evie might never have made it to her 16th birthday.

Rachel Booker has a difficult start in life. When her father dies deep in gambling debt, her mother must harden herself to make ends meet but becomes so hard she has little room left for affection or warmth. Mother and daughter work at the open market in Birmingham, selling second-hand clothes or whatever they can find just to put a little food on the table. But the market has a silver lining: it's there that Rachel makes her first childhood friend, Danny.

Two very different girls from this tight-knit community join up as ARP Wardens to do their bit for the home front. Violet Simms lives with her controlling, widowed mother who runs the local pawn shop. At just 20-years-old, Violet longs for friendship, love and escape. It seems her dreams might come true until tragedy strikes on one of the very worst nights of the Birmingham Blitz. Grace Templeton is the eldest in her family of 10 children. Spirited Grace is determined never to become burdened by child bearing and drudgery like her mother. 

1940: As war closes in and the bombs fall, on the Homefront, two sisters must find their place in a new world of ‘men's' work, in which a telegraph can break your heart and nothing in the future is certain. Growing up in Birmingham, Sylvia and Audrey Whitehouse were always like chalk and cheese. As young women, while Sylvia dreams of her forthcoming life married to fiancé Ian. Audrey can't bear the thought of being tied down by marriage and children.

Lavender Road boasts a pawnbroker, a pub, two rows of terraced working class homes and, at one end, the big house owned by the local brewer. When war breaks out, the lives and fortunes of the families who live in Lavender Road are changed out of all recognition. For Joyce, it means a struggle to keep food on the family table; for Jen it may mean the end of her dream to become an actress; and for Pam, there is the sickening seesaw of emotions as she fights attraction to her handsome lodger and a growing distance from a husband who is judged not fit to enlist.

The Second World War has finally come to a close. Birmingham is welcoming home its menfolk, and a new chapter is beginning in Rachel Booker's life. Her husband has returned, and the family that struggled for survival throughout the uncertain war years is now together. But family life settles into a routine, and Rachel, unsatisfied, starts to yearn for more.

Bristol, 1939. School leaver Maisie Miles suspects her father, a small-time crook, has an ulterior motive for insisting she gets a job at the W. D. & H. O. Wills tobacco factory but keeps it to herself. She's befriended by effervescent Phyllis Mason and kind-hearted Bridget Milligan who take pity on her and take Maisie under their wing. But beneath their happy-go-lucky exteriors, they all harbour dreams and worries about what the future holds. 

Christmas Eve, 1909. When 11-year-old Lily Larkin is left to fend for herself in an East London workhouse after her dying mother is taken to an infirmary, her future looks bleak. Once she is separated from her twin brother, Davy, her childhood hopes seem to shatter. But Lily's fierce spirit - along with her beloved new friends - help her to endure the miserable drudgery of life at South Grove Workhouse and its cruel supervisor, Miss Fox.

Rose and Myrtle Sylvester look up to their older sister, Peggy. She is the sensible, reliable one in the household of women headed by their grandmother, Grace Booth, and their mother, Mary Sylvester. When war is declared in 1939 they must face the hardships together and huge changes in their lives are inevitable. For Rose, there is the chance to fulfil her dream of becoming a clippie on Sheffield's trams like Peggy. But for Myrtle, the studious, clever one in the family, war may shatter her ambitions.

Sisters Margaret and Annie lost their mother years ago; they long for her every day. Their frightfully protective father keeps the girls close, but he can't protect them forever.... When a scandal rocks the family, the girls are forced to leave their home. The girls flee to Birmingham's jewellery quarter to stay with the one person they can rely on - Uncle Goldsmith. Annie takes up work at a nearby factory, where she learns to forge cutlery, and Margaret is employed as a chain maker.

Emma Brown is a happy-go-lucky child, content to work hard at school, and to play hopscotch with her friends on the pavement outside her house in the run-down Nechells area of Birmingham. As long as everything is all right at home with her Ma and Pa, her little sister Joyce and brother Sid, then life is good. But after Em's mother, Cynthia, has her baby she just doesn't seem to be able to cope.

It's 1939, and the Brogan family of London's East End are ready to show Hitler what for. But things don't seem so rosy when rationing, evacuation and air raids start to put this larger-than-life family to the test. When a mysterious young man arrives at the Brogans' local parish church, he provides just the dazzling distraction they need - and, for eldest daughter Mattie, the promise of more than she'd ever wished for. But as the pair fall deeper in love, they are drawn into secret dangers, rife on the very London streets they call home.

December 1930. With the Depression biting deeper, it looks like many children in the East End will wake up to nothing on Christmas morning. Widower Robbie Graham earns just enough to put food on the table for his children, Ben and Ruthie. Local cake shop owner Flo Hawkins can't bear the thought of any child having nothing for Christmas. Along with her sister, Honour, she hatches a plan to bring some festive cheer to the community.

Family of Women is the story of three generations of women. Bessie: scarred by a childhood of poverty in the slums of Victorian Birmingham and left a young widow with four children, is a hard, bullying woman who will go to disturbing lengths to keep her family under her thumb. Violet: one of Bessie's four children, marries young to escape, into the arms of a man whose life will be broken by war. Linda: grows up on a large housing estate in the 1950s with older sister Joyce and her beloved young sister Carol. Intelligent and energetic, she craves education and something more than the life she sees around her.

Maryann Nelson's widowed mother, Flo, sees the opportunity to better her family by marrying the local undertaker, Norman Griffin. Though on the surface a caring family man, Maryann and her sister, Sal, soon discover that he has another side to him. For Sal, it is too much to bear and she escapes, leaving Maryann to take revenge on Griffin. The chance of a new life opens up when she befriends Joel Batholomew, who works on the canal. Aboard his narrowboat, she finds herself falling in love with her new life.