London, 1938: Lizzie Larch is a 20-year-old hat maker in London's east end. She is happy and popular, but she carries a secret. Seven years ago she was viciously attacked and recovered in a private sanatorium where she miscarried a child. Lizzie has no memory of the night of the attack, but secrets cannot stay secret for too long. When she starts courting her boss' nephew, a shocking revelation surfaces; threatening to destroy their new-found happiness.

When Sally, Beth, Margaret and Rachel meet at a job interview for the wonderful new store in Oxford Street, they have no idea they will become lifelong friends. When all four girls are lucky enough to be selected as sales staff their exciting new adventure begins. Join them as they overcome heartbreak and grief, find love and happiness and remain united in their friendship, whatever life throws at them.

Bristol, 1939. School leaver Maisie Miles suspects her father, a small-time crook, has an ulterior motive for insisting she gets a job at the W. D. & H. O. Wills tobacco factory but keeps it to herself. She's befriended by effervescent Phyllis Mason and kind-hearted Bridget Milligan who take pity on her and take Maisie under their wing. But beneath their happy-go-lucky exteriors, they all harbour dreams and worries about what the future holds. 

Devon, 1918. When Jessie Hale loses her nursing job, she leaves London to become the nurse maid to the Kendle family. On arrival she finds the family in disarray. When their elderly Nanny suffers a bad fall, Jessie has to try to bring the household together. Gradually, Jessie finds her place in their lives. Jessie soon starts to love her life at Kendlebury Hall, but problems arise when her feelings for her employer start to change.... 

December 1930. With the Depression biting deeper, it looks like many children in the East End will wake up to nothing on Christmas morning. Widower Robbie Graham earns just enough to put food on the table for his children, Ben and Ruthie. Local cake shop owner Flo Hawkins can't bear the thought of any child having nothing for Christmas. Along with her sister, Honour, she hatches a plan to bring some festive cheer to the community.

Liverpool 1939: Olivia Campbell appears to have the perfect life. However, behind closed doors she lives in constant fear of her abusive father and has no support from her mother. Longing for love and affection, she begins a relationship with Ted, a young lad who works in her father's factory. But her family disapprove of the relationship and forbid them from seeing each other.

At the heart of Dover's Market Square lies the Castle's Café. A bustling, homely place run by the formidable Nellie Castle and her six children. Since the scandalous birth of her beloved son 10 years before, Marianne, Nellie's eldest daughter, has preferred to stay in the kitchen, hidden away from the town gossips. Overcome with shame, Marianne has never revealed the name of Donny's father - not even to her own mother. But with World War II just around the corner, Marianne's past catches up with her. And suddenly the lives of the Castle family become a lot more complicated.

Liverpool, 1939. Bella Rogers thought her life was just starting; she can’t wait to get married to her childhood sweetheart, Bobby. But when war is declared and Bobby is called up, his letters stop, leaving Bella heartbroken and alone. Then her family is torn apart by tragedy when her angelic 5-year-old sister dies from a terrible illness. They can barely afford a funeral, but the church is packed with the entire community, devastated for their loss. Grieving for her sister and lost love, Bella finds a job at the Bryant and May factory, making matches.

The tree that Cotton Cooper was sleeping under as an infant was struck by lightning. As a result, his hair is white (the color of cotton). He is a young man now, but his reflexes are ultrafast. He hears better and sees sharper than the average person. He travels west to visit his brother Paul, who is a captain in the cavalry at Fort Laramie. While visiting, his brother gets orders to take a company of men and help 600 Pawnee Indians move south to the town of Pawnee in Indian Territory.

In 1820, Salem Street is sparkling and new: eight small terraced houses built by a Lancashire mill owner for his best workers. Annie Gibson's family is one of the first to move in - a step up in the world for them. But when her mother dies, Annie's happy childhood ends and she is left to bring up her brother and sister. Red-haired, intelligent and startlingly pretty, Annie soon finds herself banished from home by a jealous stepmother. She finds work in the local doctor's household, where she learns about the fascinating world outside Salem Street.

1950s Liverpool. In the tight-knit community of the Four Streets, two girls are growing up. One is motherless and hated by the cold woman determined to take her dead mother's place. The other is hiding a dreadful secret which she dare not tell to anyone. The people of Four Streets laugh, grieve and hope together. But what can they do when a betrayal at the heart of their world comes to light?

Newly married to dashing RAF officer Tom, Irene Farley leaves behind her safe countryside life to move in with his family by the docks in South Shields. Little prepares her for the devastation the Jerry bombers have wreaked on the Sixteen Streets or that they would be living under her mother-in-law's roof, alongside Tom's three brothers and two wives!

It is 1937, and Alice, Edith and Marg continue to face hardships every day, growing up on one of the poorest streets in Blackpool. Penniless, their friendship has helped them survive this far, but it'll take more than that to see them through the dark days ahead. Alice is coping with a violent father. Marg is left reeling after a dark secret about her birth comes to light and threatens to destroy the life she knows, and Edith is fighting to protect her alcoholic mother from the shame of their neighbours and keep her brother on the straight and narrow. 

After the heartbreak of World War Two, newlywed midwife Cathy hoped Liverpool life would offer some joy. But a terrible miscarriage and the escape of her abusive stepfather Jack from prison make happiness hard to find. Meanwhile, Cathy’s beloved granny is ailing. Whilst at the hospital, Cathy sees her midwifery friends, who are planning to open a home for unmarried mothers. After losing a baby of her own, Cathy would love to help, but for now, she must take care of her grandmother.  

Having suffered much cruelty at the hands of her father, Isabel Kenton is shocked to hear after his death that he was not her real father. Isabel inherits their house while her twin brother, Mark, is left the family steel works. But when World War I breaks out, Mark joins the RAF, and Isabel must take responsibility for the management of the business. Struggling to keep the business alive, she must also discover who she really is.